A5043937184- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical Analysis and Sensing Techniques
- Pancreatic function and diabetes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Child Nutrition and Feeding Issues
- Biochemical effects in animals
- Apelin-related biomedical research
- Eicosanoids and Hypertension Pharmacology
- Immune Cell Function and Interaction
- Neuropeptides and Animal Physiology
- Endoplasmic Reticulum Stress and Disease
- High Altitude and Hypoxia
- Epigenetics and DNA Methylation
- Diabetes Management and Research
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Single-cell and spatial transcriptomics
- Sirtuins and Resveratrol in Medicine
- Receptor Mechanisms and Signaling
- Neurobiology and Insect Physiology Research
- Kruppel-like factors research
Max Planck Institute for Metabolism Research
2019-2024
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2022-2024
University of Cologne
2024
University Hospital Cologne
2022-2024
Columbia University
2014-2019
Universidad Autónoma de Madrid
2006-2012
Consejo Superior de Investigaciones Científicas
2007-2012
Centro de Biología Molecular Severo Ochoa
2007-2011
Hospital Universitario Fundación Jiménez Díaz
2006
Abstract Agouti-related peptide (AgRP)-expressing and proopiomelanocortin (POMC)-expressing neurons reciprocally regulate food intake. Here, we combine non-interacting recombinases to simultaneously express functionally opposing chemogenetic receptors in AgRP POMC for comparing metabolic responses male female mice with simultaneous activation of inhibition isolated or neurons. We show that intake is regulated by the additive effect neuron inhibition, while systemic insulin sensitivity...
Abstract Activation of Agouti-Related Peptide (AgRP)-expressing neurons promotes feeding and insulin resistance. Here, we examine the contribution neuropeptide Y (NPY)-dependent signaling to diverse physiological consequences activating AgRP neurons. NPY-deficient mice fail rapidly increase food intake during first hour either chemo- or optogenetic activation neurons, while delayed in is comparable between control mice. Acutely stimulating fails induce systemic resistance mice, increased...
Leptin is well known for its role in the regulation of energy homeostasis adults, a mechanism that at least partially results from inhibition activity NPY/AgRP/GABA neurons (NAG) arcuate nucleus hypothalamus (ARH). During early postnatal development rodent, leptin promotes axonal outgrowth ARH neurons, and preautonomic NAG are particularly responsive to leptin9s trophic effects. To begin understand how could simultaneously promote inhibit we characterized electrochemical effects on mice...
Intronic polymorphisms in the α-ketoglutarate–dependent dioxygenase gene (FTO) that are highly associated with increased body weight have been implicated transcriptional control of a nearby ciliary gene, retinitis pigmentosa GTPase regulator-interacting protein-1 like (RPGRIP1L). Previous studies shown congenital Rpgrip1l hypomorphism murine proopiomelanocortin (Pomc) neurons causes obesity by increasing food intake. Here, we show and adult-onset deletion Pomc-expressing hyperphagia likely...
Insulin, like leptin, is considered as a lipostatic signal acting at central level. Aging and age-associated adiposity have been related to the development of leptin resistance in Wistar rats. In present article, hypothalamic insulin response during aging has studied Thus, effects intracerebroventricular infusion week on food intake body weight well transduction after acute administration 3-, 8-, 24-month-old To explore possible role adiposity, these experiments were also performed 8- rats 3...
Humans and animals exposed to undernutrition (UN) during development often experience accelerated "catch-up" growth when food supplies are plentiful. Little is known about the mechanisms regulating early rates. We previously reported that actions of leptin presynaptic inputs orexigenic NPY/AgRP/GABA (NAG) neurons in arcuate nucleus hypothalamus almost exclusively excitatory lactation period, since neuronal humoral inhibitory systems do not develop until after weaning. Moreover, we identified...
Dopamine acts on neurons in the arcuate nucleus (ARC) of hypothalamus, which controls homeostatic feeding responses. Here we demonstrate a differential enrichment dopamine receptor 1 (Drd1) expression food intake-promoting agouti related peptide (AgRP)/neuropeptide Y (NPY) and large proportion Drd2-expressing anorexigenic proopiomelanocortin (POMC) neurons. Owing to nature these receptors, this translates into predominant activation AgRP/NPY upon stimulation larger dopamine-inhibited POMC...
Ageing is a major risk factor for the development of metabolic disorders linked to dyslipidemia, usually accompanied by increased adiposity. The goal this work was investigate whether avoiding an excessive increase in adiposity with ageing, via moderate chronic food restriction (FR), ameliorates postprandial dyslipidemia rat model syndrome associated ageing. Accordingly, we performed oral lipid loading test (OLLT) mature middle-aged (7 months) and middle-old-aged (24 Wistar rats fed ad...
Inhibition of the JAK2/STAT pathway has been implicated recently in cytoprotective mechanisms both vascular smooth muscle cells and astrocytes. The advent JAK2-specific inhibitors provides a practical tool for study this different cellular types. An interest finding methods to improve endothelial cell (EC) resistance injury led us examine effect inhibition on EC protection. Furthermore, signaling pathways involved inhibition-related actions were examined. Our results reveal, first time, that...
SUMMARY Inhibitors of intestinal glucosidases have been shown to improve glycaemic control in diabetic and obese humans animals. In the present study, we investigated effect 3 months treatment with acarbose on adiposity, food intake modulation hypothalamic neuropeptide Y (NPY) Wistar (WDF) rats possible correlation between changes overall insulin sensitivity level circulating adipokines, leptin adiponectin. addition, adipocyte signalling. Mature male WDF were randomly distributed one three...