A5052667450- Natural Antidiabetic Agents Studies
- Metabolism, Diabetes, and Cancer
- Drug-Induced Hepatotoxicity and Protection
- Ethnobotanical and Medicinal Plants Studies
- Ziziphus Jujuba Studies and Applications
- Pharmaceutical Practices and Patient Outcomes
- Diet, Metabolism, and Disease
- Air Quality and Health Impacts
- Pancreatic function and diabetes
- Nephrotoxicity and Medicinal Plants
- Natural product bioactivities and synthesis
- Sirtuins and Resveratrol in Medicine
- Phytochemistry and Biological Activities
- Pharmaceutical studies and practices
- Calcium signaling and nucleotide metabolism
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Medicinal Plants
- Phytochemicals and Medicinal Plants
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Pomegranate: compositions and health benefits
- Energy, Environment, and Transportation Policies
- Toxin Mechanisms and Immunotoxins
- African Botany and Ecology Studies
- Calpain Protease Function and Regulation
Centre National de la Recherche Scientifique
2008-2024
Centre National de la Recherche Scientifique et Technologique
2024
Institut de Recherche en Sciences de la Santé
2024
École Nationale Supérieure de Chimie de Montpellier
2014-2024
Université de Montpellier
2008-2024
Institut des Biomolécules Max Mousseron
2014-2024
Université Joseph Ki-Zerbo
2016-2024
Joseph Ayo Babalola University
2023
Université Libre de Bruxelles
2015-2020
Physiol (Belgium)
2020
BACKGROUND AND PURPOSE Quercetin lowers plasma glucose, normalizes glucose tolerance tests and preserves pancreatic β‐cell integrity in diabetic rats. However, its mechanism of action has never been explored insulin‐secreting β‐cells. Using the INS‐1 line, effects quercetin were determined on glucose‐ or glibenclamide‐induced insulin secretion dysfunctions induced by hydrogen peroxide (H 2 O ). These analysed along with activation extracellular signal‐regulated kinase (ERK)1/2 pathway....
The pharmacology of polyphenol metabolites on beta-cell function is largely undetermined. We sought to identify that enhance the insulin-secreting beta-cells and explore underlying mechanisms.INS-1 rat isolated islets Langerhans or perfused pancreas preparations were used for insulin secretion experiments. Molecular modelling, intracellular Ca2+ monitoring, whole-cell patch-clamp recordings mechanistic studies.Among a set metabolites, we found exposure INS-1 urolithins A C enhanced...
We previously showed that grape extracts enriched in different polyphenolic families were similarly able to prevent reactive oxygen species (ROS) production, although having differential effects on various features of metabolic syndrome when administered at a dose 21 mg/kg the fructose (60%)-fed rat (a model syndrome). In present work, we analyzed same effect pure molecules (catechin, resveratrol, delphinidin, and gallic acid) 2.1 mg/kg. Delphinidin acid prevented insulin resistance, while...
Insulin secretion preservation is a major issue for the prevention or treatment of type 2 diabetes. We previously showed on β-cells that quercetin (Q), but not resveratrol (R) N-acetyl cysteine (NAC), amplified glucose-induced insulin in calcium- and ERK1/2-dependent manner. Quercetin, NAC, also protected β-cell function hyperamplified ERK1/2 phosphorylation oxidative stress conditions. As may interfere with other stress-activated protein kinases (JNK p38 MAPK), we further explored MAPK...
Introduction: Balanites aegyptiaca L. (DEL) is a plant used in Burkina Faso traditional medicine to treat gastrointestinal parasitosis. The purpose of this study was assess the vitro anthelmintic activity aqueous and hydro-ethanolic macerates (AM HEM) fruit mesocarp from against Haemonchus contortus. Methods: Phytochemical screening extracts done using thin-layer chromatography. egg hatch inhibition assay (EHIA) at 0.125, 0.15, 0.25, 0.625, 1.25, 5 mg/mL Adult worms mortality (AWMA) 2.5, 5,...
Cocoa bean shell (CBS), a by-product with considerable concentrations of bioactive compounds and proven biofunctional potential, has been demonstrated to be suitable ingredient for high-fiber functional biscuits adapted diabetic consumers. In this work, the in vitro bioaccessibility intestinal absorption polyphenols methylxanthines contained these were evaluated, effect food matrix was studied. Biscuits containing CBS alone underwent digestion followed by an permeability study. The results...
Balanites aegyptiaca del. (Zygophyllaceae) is widely used in traditional medicine, both human and veterinary, throughout Africa for its many properties, including antiparasitic properties. This experimental study aims to optimise the extraction conditions of seeds Aqueous maceration was carried out with mass volume ratios 40%, 30%, 20%, 10% 5% times 6, 12, 24, 36 48 hours. Extraction yields, phytochemical screening, saponins assay, antioxidant activities (ABTS FRAP) tests on Heligmosomoides...
Background: Sclerocarya birrea (A. Rich). Hochst, popularly known as Morula, is a plant in the Anacardiaceae family. The bark, fruits, and leaves have traditionally been used to manage variety of health conditions, most especially diabetes. Unfortunately, there scarcity data publications on toxicity safety this plant. Purpose: current study was designed assess acute chronic hydro-ethanolic extract albino rats. Materials Methods: extracted using an 80– 20% solution. For study, female Wistar...
L. (Malvaceae) is a plant used in Burkina Faso for the treatment of various ailments including asthma. The aim study was to evaluate pharmacological relaxant effect leafy stem extracts
Abstract Background Ziziphus mauritiana Lam. is a plant used in traditional medicine Burkina Faso the treatment of several diseases, which diabetes characterized by oxidative stress. The aim this study was to evaluate vitro antioxidant potential extracts leaves plant. Methods crude hydroethanolic extract (HEE) Z. and their partitionates n -hexane, dichloromethane, ethyl acetate, residual aqueous solution (the F1, F2, F3, F4 fractions, respectively) were first prepared. content polyphenols...
Global Tuberculosis (TB) control is facing major challenges such as occurrence of multidrug-resistant (MDR) and extensively drug-resistant tuberculosis (XDR). The current TB drugs are getting less effective associated with side effects limiting their use, especially MDR XDR infected patients. In Mali, many medicinal plants used against various diseases including bacterial infections. study aimed at studying the antimycobacterial activities 60 extracts from 22 Malian medicinal. antibacterial...
Medicinal treatment of arterial hypertension (AH) may cause adverse effects which can be annoying and thus influence patient's compliance with treatment. Our study focused on these undesirable in patients followed up for AH an ambulatory basis the Department Cardiology at University Hospital Yalgado Ouédraogo from July to September 2015. aim was determine their rates characteristics. Data were obtained patients' interview, examination follow-up records medical consultation forms. A total 278...
Traditional healers combine four medicinal plants (Cochlospermum tinctorium, Terminalia macroptera, Leptadenia hastata and Commiphora Africana to treat hepatitis in Burkina Faso. The aimed was evaluate the hepato-curative activity of lyophilized aqueous decoction (LAD) hydroethanolic macerate (LHM) plant extracts on CCl4-induced rats. We assessed acute toxicity scavenging 2, 2-Diphenyl-1-picrylhydrazyl (DPPH). Hepato-curative study included nine groups with five rats each. used as followed:...
Résumé : L’objet de ce travail était d’étudier les paramètres à prendre en compte lors l’élaboration du formulaire thérapeutique CHU Pr Bocar Sidy SALL Kati. Il s’agissait d’une étude transversale descriptive. La collecte des données s’est déroulée sur une période 6 mois 2022. Elle a concerné 70% l’effectif médecins (n=42) et 30% Sages-femmes infirmiers (n=23) dudit établissement partir entrevues individuelles. ressort résultats que près 2/3 prescripteurs, sages-femmes 1/2 connaissaient le...
The pharmacology of flavonoids on β-cell function is largely undefined especially in the context defective secretion insulin. We sought to identify that increased insulin-secreting β-cells and explore underlying mechanisms.
Objective: The aim of this study was to evaluate the hepatoprotective effect combination. Methods: Serum liver markers, tissue antioxidant activity, and histological changes in livers rats from blank, negative (distilled water), positive (silymarin 100 mg/kg bw), test (combination 500 bw) groups were measured after 7 days pretreatment induction hepatotoxicity by 10 g/kg bw alcohol every 12 h for 48 h. Results: Rats control group showed a highly significant (p<0.001) increase aspartate...
Background/Objectives: Balanites aegyptiaca Del. (Zygophyllaceae) is widely used in traditional medicine, both human and veterinary, throughout Africa for its many properties, including antiparasitic properties. This experimental study aims to optimize the extraction conditions of seeds Methods: Aqueous maceration was carried out with mass-to-volume ratios 40%, 30%, 20%, 10% 5% times 6, 12, 24, 36 48 h. Extraction yields, phytochemical screening, saponins assay, antioxidant activities ABTS+...
Inflammation is the reaction of immune system to an external or internal aggression organism. The symptoms (redness, edema, heat and pain) are secondary increase in vascular permeability. hydroethanolic extract has anti-inflammatory properties vitro. aim was examine analgesic activities extracts alone combination. activity studied using carragenan-induced paw edema type interactions between two determined by combination index on isobologram. Acetic acid-induced torsion Haffner's tail clamp...