A5010300392- Immunotherapy and Immune Responses
- Immune cells in cancer
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Cell Adhesion Molecules Research
- Pancreatic and Hepatic Oncology Research
- Macrophage Migration Inhibitory Factor
- Virus-based gene therapy research
- 3D Printing in Biomedical Research
- vaccines and immunoinformatics approaches
- Cellular Mechanics and Interactions
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Protease and Inhibitor Mechanisms
- T-cell and B-cell Immunology
- Galectins and Cancer Biology
Herlev Hospital
2022-2023
Copenhagen University Hospital
2017-2023
University of Copenhagen
2022
Technical University of Denmark
2021
Expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) is a central immunosuppressive mechanism mediated by tumor-educated myeloid cells. Increased activity ARG1 promotes formation an microenvironment and leads to more aggressive phenotype in many cancers. Intrinsic T-cell immunity against ARG1-derived epitopes peripheral blood cancer patients healthy subjects has previously been demonstrated. To evaluate antitumor efficacy peptide vaccines as monotherapy combinational therapy...
Pancreatic ductal adenocarcinoma (PDAC) is associated with very poor survival, making it the third and fourth leading cause of all cancer-related deaths in USA European Union, respectively. The tumor microenvironment (TME) PDAC highly immunosuppressive desmoplastic, which could explain limited therapeutic effect immunotherapy PDAC. One key molecules that contributes to immunosuppression fibrosis transforming growth factor-β (TGFβ). aim this study was target fibrotic TME using a novel immune...
One way that tumors evade immune destruction is through tumor and stromal cell expression of arginine-degrading enzyme arginase-2 (ARG2). Here we describe the existence pro-inflammatory effector T-cells recognize ARG2 can directly target tumor-infiltrating cells. Using a library 34 peptides covering entire sequence, examined reactivity toward these in peripheral blood mononuclear cells from cancer patients healthy individuals. Interferon-γ ELISPOT revealed frequent responses against several...
Galectin-3 (Gal3) can be expressed by many cells in the tumor microenvironment (TME), including cancer cells, cancer-associated fibroblasts, tumor-associated macrophages, and regulatory T (Tregs). In addition to immunosuppression, Gal3 expression has been connected malignant cell transformation, progression, metastasis. present study, we found spontaneous T-cell responses against Gal3-derived peptides PBMCs from both healthy donors patients. We isolated expanded these Gal3-specific vitro...
Adoptive T-cell transfer (ACT) offers a curative therapeutic option for subsets of melanoma and hematological cancer patients. To increase response rates broaden the applicability ACT, it is necessary to improve post-infusion performance transferred T cells. The design improved treatment strategies includes cells with less differentiated phenotype. Such cell have high proliferative potential but require stimulatory signals in vivo differentiate into tumor-reactive effector Thus, combination...
High expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune or cells tumor stroma can reduce availability arginine (L-Arg) in microenvironment (TME). Depletion L-Arg has detrimental consequences for T and leads to T-cell dysfunction suppression anticancer responses. Previous work from our group demonstrated presence proinflammatory ARG2-specific CD4 that inhibited growth murine models on activation with ARG2-derived peptides. In this study, we investigated...
Induction of a lasting protective immune response is dependent on presentation epitopes to patrolling T cells through the HLA complex. While peptide:HLA (pHLA) complex affinity alone widely exploited for epitope selection, we demonstrate that including pHLA stability as selection parameter can significantly reduce high false discovery rate observed with predicted affinity. In this study, was measured three common class I alleles and 1286 overlapping 9-mer peptides derived from SARS-CoV-2...
<div>Abstract<p>Expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) is a central immunosuppressive mechanism mediated by tumor-educated myeloid cells. Increased activity ARG1 promotes formation an microenvironment and leads to more aggressive phenotype in many cancers. Intrinsic T-cell immunity against ARG1-derived epitopes peripheral blood cancer patients healthy subjects has previously been demonstrated. To evaluate antitumor efficacy peptide vaccines as...
<p>Collected supplementary data file with figures and figure legends.</p>
<div>Abstract<p>Expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) is a central immunosuppressive mechanism mediated by tumor-educated myeloid cells. Increased activity ARG1 promotes formation an microenvironment and leads to more aggressive phenotype in many cancers. Intrinsic T-cell immunity against ARG1-derived epitopes peripheral blood cancer patients healthy subjects has previously been demonstrated. To evaluate antitumor efficacy peptide vaccines as...
<p>Collected supplementary data file with figures and figure legends.</p>