A5061076243- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac tumors and thrombi
- Healthcare Systems and Public Health
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Issues in Pregnancy
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Inflammatory mediators and NSAID effects
- Sleep and Wakefulness Research
- Infective Endocarditis Diagnosis and Management
- Obstructive Sleep Apnea Research
- Aortic aneurysm repair treatments
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Menopause: Health Impacts and Treatments
- Sleep and related disorders
- Endometriosis Research and Treatment
- Gout, Hyperuricemia, Uric Acid
- Aortic Disease and Treatment Approaches
- Congenital Heart Disease Studies
- Connective tissue disorders research
- Protease and Inhibitor Mechanisms
Federal Almazov North-West Medical Research Centre
2012-2024
Ministry of Health of the Russian Federation
2020
Hospital de São João
2014
Centre Hospitalier Universitaire de Liège
2014
Seoul National University Hospital
2013
Azienda Ospedaliero Universitaria San Giovanni Battista
2013
University of Turin
2013
Türkiye Yüksek İhtisas Hastanesi
2013
Aim . To evaluate the effect of angiotensin II receptor blocker (ARB) therapy on expression transforming growth factor-β (TGF-β) in myxomatous mitral valve, serum levels TGF-β1/TGF-β2 and left ventricular (LV) systolic function patients with valve prolapse (MVP). Material methods The retrospective non-randomized single-center study included 233 who underwent surgical treatment severe regurgitation due to MVP. Preoperative drug was assessed using case records. Transthoracic echocardiography...
Purpose: The inhibition by angiotensin II receptor blockers (ARB) the transforming growth factor-b (TGF-b) induced extracellular matrix production has been shown recently in cultured valvular interstitial cells obtained from patients with mitral valve prolapse (MVP) undergoing repair. Our aim was to evaluate effect of ARB therapy on TGF-b serum level and possible impact myxomatous degeneration left ventricular (LV) systolic dysfunction MVP patients. Methods: A total 233 asymptomatic (mean...
High cardiovascular mortality (CVD) determines the relevance of their effective primary and secondary preventive measures, based on principles a clinical-epideomyological approach isolation risk factors (RFs). Until now, CVD have been leading cause deterioration in demographic indicators population all countries. According to WHO, they account for up 31 % deaths 59 deaths. Adherence healthy lifestyle, reduction main RFs at level can prevent 80 premature At same time, clinical manifestations...
The review describes a rarely occurring state of commotio cordis (CC) — ventricular fibrillation (VF), associated with unintentional blunt impact on the anterior thoracic wall in absence structural damage to heart. development VF is based coincidence time closed breast trauma vulnerable period during early repolarization (the so-called "vulnerability window"). More often, death occurs instantly or coming minutes post-traumatic period. CC more common male adolescents and seems be second...
Background: The risk stratification of chronic heart failure (CHF) patients can be performed using echocardiographic markers left ventricle (LV) dysfunction, such as the ejection fraction (EF).LV global longitudinal strain (GLS) showed to a sensitive measure myocardium deformation.However, its role prognostic marker in CHF with exclusively systolic dysfunction is still poorly addressed.Objectives: This study sought evaluate incremental twodimensional (2D) LV GLS outpatients.Methods:...
Background . Atrial fibrillation (AF) is the most frequent arrhythmia. The method of catheter radiofrequency ablation (CRA) pulmonary veins (PV) does not guarantee preservation sinus rhythm. Determination predictors AF relapses dictates need in systemic approach taking into account demographic and clinical-instrumental characteristics patients. Objective preoperative recurrence within 3 year after follow-up CRA PV. Design methods study included 89 patients (50 men, 39 women; mean age 58 62...
Abstract Funding Acknowledgements Type of funding sources: None. Introduction Improvement in malignant ventricular arrhythmias (VA) has been reported after mitral valve surgery some prolapse patients (MVP) with severe degenerative regurgitation. Mitral annular disjunction, posterior systolic curling, and abnormal contractility are associated arrhythmic MVP underwent correction during the repair. However, disease progression substrates (left fibrosis papillary muscles basal wall) could be...
Abstract Growing evidence supports role transforming growth factor-β (TGF-β) as a mediator of the myxomatous changes in mitral valve prolapse. Recently, angiotensin II receptor blockers (ARB) emerged potentially effective inhibitor TGF-β signaling. Treatment valvular interstitial cells (VICs) with ARB resulted inhibition TGF-β-induced ECM expression. Our aim was to evaluate effect preoperative therapy modulation effects on degeneration. Methods A total 233 asymptomatic patients (mean age:...
The article summarizes a long-term follow-up experience on the patients underwent various operation types cardiac valves, specifics of individualized approach at outpatient stage, reach optimal hypocoagulation taking recent guidelines, prevention and early diagnostics prosthesis-related complications, as principals management necessity extracardiac surgical interventions for pregnant.
Aim. To assess systolic left ventricular (LV) function in patients with mitral valve prolapse (MVP) and different morphological MV disorders. Material methods. The study included 233 (mean age 53,8±12,9 years), who underwent surgery due to MPV severe regurgitation (MR) at the V. A. Almazov Federal Centre of Heart, Blood, Endocrinology 2009-2011. resected segments a pathomorphological examination; preoperative strain rate were assessed speckle tracking method (EchoPAC’08). Results. Based on...
Aim To evaluate the effect of mitral valve (MV) repair and replacement on incidence ventricular arrhythmias (VA) to identify risk factors for persistence VA in patients with MV prolapse severe regurgitation (MR) during a mid-term follow-up. Material methods A single-site observational, prospective study successively enrolled 30 (mean age, 55.2±9.9 years, 60% men) who underwent or MR due chordal avulsion. Transthoracic echocardiography Holter monitoring were performed all before annually...
BackgroundPreoperative LV systolic function is an important prognostic factor in patients undergoing mitral valve surgery. Strain and strain rate (SR) helps to identify subclinical dysfunction with severe regurgitation (MR). The purpose of this study was determine the impact underlying etiology (Barlow's disease, BD or fibroelastic deficiency, FED) on degenerative disease.MethodsWe studied 233 (mean age: 53.8±12.9) surgery for MR at Almazov Centre between 2009 2011. Pathologic diagnoses...
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Abstract Transforming growth factor-β (TGF-β) is a multifunctional cytokine with fibrogenic properties. Also increased TGF-β signaling contributes to the development of myxomatous changes mitral valve (MV). Recent data suggests that may play potentially important role in heart arrhythmogenesis. Our aim was evaluate possible proarrhythmic effects patients prolapse (MVP) and severe regurgitation (MR) undergoing MV repair. Methods 30 consecutive (mean age 53.1±9.4, 47% male) repair for MR due...
Abstract Introduction There is limited data on the efficacy of surgical repair in reducing ventricular arrhythmia (VA) mitral valve prolapse (MVP) patients. Improvement malignant arrhythmias has been reported only isolated cases after surgery. Our aim was to evaluate possible effects left (LV) reverse remodeling and incidence VA MVP patients mid-term follow-up. Methods 30 consecutive (mean age 53.1 ± 9.4, 47% male) undergoing for severe regurgitation (MR) due were enrolled our observational,...
Thromboembolic complications is a frequent cause of acute cardiovascular events, disability and mortality. Among the factors that increase their risk in female population using medications, containing sex hormones high significance. In oral contraceptives main — contraceptive activity belongs to gestagen, while estrogen performs an auxiliary function menstrual cycle control. medications used for therapy during menopause active substance estrogen. Progestin provides prevention endometrial...
Data from an original study evaluating the efficacy and safety of dexketoprofen in conservative treatment pain syndrome patients are presented. This paper presents three clinical cases successful patients. Patients, depending on therapy they received, were divided into groups: patient S., 50 years old, (pain joints) received Dexketoprofen-SZ at a dose 25 mg twice day for 5 days; patient, (severe lumbosacral spine) every 8 hours (daily not more than 75 mg) 20 (painful heavy periods)...
Data from an original study evaluating the efficacy and safety of doxylamine in treatment insomnia cardiac patients are presented. Materials methods. Ten with sleep disorders were under observation. Doxylamine-SZ was prescribed to 10 (seven women three men aged 40 60 years) who consulted a cardiologist disturbances 2 7 times week last month. Patients received at dose 1/2 tablet 15 mg 30 minutes before bedtime. Six noted normalization after 2–3 days taking drug discontinued drug, four had...