A5044292630- Electrochemical sensors and biosensors
- Vitamin C and Antioxidants Research
- Fluorine in Organic Chemistry
- Catalytic C–H Functionalization Methods
- Analytical Chemistry and Sensors
- Synthesis and Catalytic Reactions
Huaiyin Normal University
2019-2025
An efficient and convenient protocol for copper-promoted oxidative mono- di-bromination of 8-aminoquinoline amides using hydrogen bromide (HBr) as the brominating reagent dimethyl sulfoxide (DMSO) a mild oxidant has been developed.
A facile and sensitive colorimetric method for determining ascorbic acid (AA) was established using MnO<sub>2</sub> nanosheets. Addition of AA to the sensor system caused transformation solution color from brown colorless.
A simple and effective method for the copper-catalyzed selective C5-H bromination difluoromethylation of 8-aminoquinoline amides with ethyl bromodifluoroacetate as bifunctional reagent was developed. The combination cupric catalyst alkaline additive results in a C5-bromination reaction, whereas cuprous combined silver C5-difluoromethylation reaction. This has broad substrate scope allows easy convenient access to desired C5-functionalized quinolones good excellent yields.