"Trojan horse" antibiotic albomycins are peptidyl nucleosides consisting of a highly modified 4'-thiofuranosyl cytosine moiety and ferrichrome siderophore that linked by peptide bond via serine residue. While the latter component serves to sequester iron from environment, seryl nucleoside portion is potent inhibitor bacterial seryl-tRNA synthetases, resulting in broad-spectrum antimicrobial activities albomycin δ(2). The isolation has revealed this biological activity optimized only...

The Trojan horse antibiotic albomycin, produced by Streptomyces sp. strain ATCC 700974, contains a thioribosyl nucleoside moiety linked to hydroxamate siderophore through serine residue. seryl structure (SB-217452) is potent inhibitor of seryl-tRNA synthetase (SerRS) in the pathogenic bacterium Staphylococcus aureus, with 50% inhibitory concentration (IC(50)) approximately 8 nM. In albomycin-producing sp., bacterial SerRS homolog (Alb10) was found be encoded biosynthetic gene cluster...

Although actinomycetes are the plant-associated environmental bacteria best known for producing thousands of antibiotics, their presence in guts flower-feeding honeybees has rarely been reported. Here, we report on selective isolation from gut microbiota healthy honeybees, and inhibitory activity against honeybee indigenous bacteria. More than 70% sampled (N>40) a season carried at least one CFU actinomycete. The isolates bees location produced bioactivities that were almost exclusively...

First-year engineering students often face challenges in electronics, struggling with fundamental concepts circuitry and problem-solving. . In our university's Project-Based Learning (PBL) course, integrating diverse components like Arduino, relays, sensors, actuators poses difficulties for students. This study delves into the faced by first-year undergraduates designing electronic circuits within a PBL framework. Emphasizing troubleshooting component, which is essential knowledge...

Education has been considered as the ladder for socio-economic development of individuals and society. Thus, there exists a demand educational institutions that provide quality education. Such an endeavor requires to be adaptive, considering incorporating appropriate teaching learning techniques address changing needs. While considerable research on understanding applying different approaches enhance through techniques, is relative lacuna in our styles students use process information. This...

Humanity has evolved, changing how one perceives and experiences emotions. Darwin states that emotions serve a purpose because they wouldn't have developed if were purely incidental. Typically, are triggered by an interior or exterior experience either positive negative meaning for the person in question. Emotional intelligence (EI) is ability to deal with situation consciously. not likely significant predictor of work success. Emotions moods distinct; former more robust less long-lasting....

TROUBLESHOOTING IN AN ONLINE CIRCUIT SIMULATION PLATFORM: A STUDY ON THE PROCESS BY FIRST-YEAR UNDERGRADUATE STUDENTS BLENDED PROJECT-BASED LEARNING COURSE

ContextImmunology as a course occupies corner stone in the domain of Biotechnology due to its relevance and applications.The significance lies critical applications like vaccines, diagnosis organ transplantation.Learning immunology at undergraduate level is often challenging task for students since it involves integration diverse concepts coherent thinking.In this context, present study employing case-studies was undertaken engineering studying immunology. Purpose or GoalThe key objectives...

ContextConventional teaching methods mostly rely on teacher centric approach and doesn't provide interdisciplinary knowledge, with that practice it is difficult for students to survive in the corporate world.In this paper a study comparison of engineering projects completed without project-based learning knowledge has been done by collecting feedback from passed out students. Purpose or GoalTo prove importance mechatronic skills project management developing quality during final year....

Abstract— This paper presents an innovative approach to enhance higher cognitive skills in students through collaboration with the industry, focusing on microcontroller education. In fastevolving landscape of technology, bridging gap between academia and industry is paramount. Our describes a course activity that leverages impart critical thinking, problem-solving, knowledge application students. The centers in-depth study Atmega32 microcontroller, chosen for its relevance rich feature set....

This study explores the integration of electronic testing kits (ETK) with preloaded program as an enhancement to Project Based Learning (PjBL) in engineering courses, focusing on hands-on learning and problem-solving. Investigating their impact first-year undergraduate students who have enrolled exploration course, research involved dividing participants into three teams. Initially, PjBL activities were conducted without kits, followed by sessions inclusion ETK. Semi-structured interviews...

ContextThe educational phenomenon being studied in this paper is the integration of hands-on activities teaching and learning Computer Organization Architecture (COA), a foundational subject computer science engineering.The aims to explore how incorporating experiences can enhance process, reinforce complex concepts develop problemsolving critical thinking skills. Purpose or GoalGiven intricate nature COA, which encompasses multitude theoretical models, it becomes imperative provide students...

ContextDeveloping problem solving skills has been an emphasis from schooling to degree programs and beyond.Problem based learning discovery oriented share several common philosophies of learning.One can be integrated into another for effective classroom delivery.On other hand, NEP 2020 aims bring develop the essential rooting our arts literature. Purpose or GoalConsidering importance learning, storytelling, this work proposes following research questions: How we integrate story telling...

Acceptance of e-learning among students in higher education institutions is crucial to a thriving educational environment. In this context, the present research focuses on exploring practices and perceptions engineering colleges Kuwait India with help adapted technology acceptance model. The survey 270 from two universities showed generally positive toward e-learning. Convenience was another factor affecting actual usage motivation India. Though some differences were observed perceived...

Formative assessments are an essential part of any student's evaluation criteria. It assesses the student holistically and helps students monitor their learning progress. allows to identify gaps between current knowledge skills they wish acquire. These have scope be automated, such advancement will inevitably improve efficiency accuracy process. Currently, some systems use a scoring guide semantic meaning extractors achieve this. There is need for solution that can analyze answers written by...

1 Center for Engineering Education Research, KLE Technological University (INDIA)2 School of Electronics and Communication Engineering, (INDIA)