A5035061723- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Sphingolipid Metabolism and Signaling
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- Neurogenesis and neuroplasticity mechanisms
- T-cell and B-cell Immunology
La Trobe University
2015-2021
The neuropsychiatric symptoms of multiple sclerosis (MS), such as anxiety and depression, can result from disease activity itself well psychological reaction to an unfavorable diagnosis. Accordingly, the literature reports evidence increased anxiety-like behavior in experimental autoimmune encephalomyelitis (EAE), accepted MS model. Due recently described critical role platelets inflammation disease, we examined relationship between platelets, inflammation, EAE. In elevated plus maze,...
Emotional and cognitive deficits associated hippocampal damage observed in multiple sclerosis (MS) are now recognized as primary disease manifestations. However, the pathological substrate of these dysfunctions is unclear. In experimental autoimmune encephalomyelitis (EAE) MS model, impaired hippocampal-dependent functions concomitant with severe microglial reactivity neurodegeneration, but reports vary respect to evidence lymphocytic infiltration, raising questions nature underlying...
Multiple sclerosis (MS) is an autoimmune disease targeting the central nervous system, characterized by unpredictable course and a wide range of symptoms. Emotional cognitive deficits are now recognized as primary manifestations not simply consequence living with chronic condition, raising questions regarding efficacy current therapeutics for these specific Mechanisms underlying psychiatric sequelae in MS believed to be similar those pathogenesis, that mediated cytokines other inflammatory...
Oral gavage is commonly used in pre-clinical drug evaluation, but potentially aversive and may induce behavioral effects independent of compounds under investigation. This study examined the combined repeated oral disease induction on anxiety-like behavior experimental autoimmune encephalomyelitis (EAE) model multiple sclerosis. The C57BL/6J NOD/ShiLtJ EAE variants were exposed to sham-EAE or untreated control conditions, either daily home cage conditions. Anxiety-like was subsequently...