A5023355775- Sexual Differentiation and Disorders
- Ovarian function and disorders
- Hypothalamic control of reproductive hormones
- Hormonal and reproductive studies
- Growth Hormone and Insulin-like Growth Factors
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Birth, Development, and Health
- Reproductive Biology and Fertility
- Effects and risks of endocrine disrupting chemicals
- Male Breast Health Studies
- Body Composition Measurement Techniques
- Ovarian cancer diagnosis and treatment
- Urological Disorders and Treatments
- Obesity, Physical Activity, Diet
- Sperm and Testicular Function
- Cancer Risks and Factors
- Adolescent Sexual and Reproductive Health
- Hormonal Regulation and Hypertension
- Pregnancy and Medication Impact
- Pregnancy-related medical research
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Fatty Acid Research and Health
- Epigenetics and DNA Methylation
- Toxic Organic Pollutants Impact
Copenhagen University Hospital
2010-2025
Rigshospitalet
2016-2025
University of Copenhagen
2016-2025
Regional Medical Center
2019
MRC Centre for Reproductive Health
2016
The Queen's Medical Research Institute
2016
University of Edinburgh
2016
Western General Hospital
2014
University of Turku
2014
King Edward Memorial Hospital and Seth G.S. Medical College
2011
Context: In adult women, anti-Müllerian hormone (AMH) is related to the ovarian follicle pool. Little known about AMH in girls. Objective: The objective of study was provide a reference range for girls and adolescents evaluate as marker function. Setting: conducted at tertiary referral center pediatric endocrinology. Main Outcome Measures: We measured 926 healthy females (longitudinal values during infancy) well 172 Turner syndrome (TS) patients according age, karyotype (A: 45,X; B:...
Anti-Müllerian hormone (AMH), which is secreted by immature Sertoli cells, triggers the involution of fetal Müllerian ducts. AMH a testis-specific marker used for diagnosis in infants with ambiguous genitalia or bilateral cryptorchidism.The aim study was to describe ontogeny secretion through life healthy males.This population-based volunteers.PARTICIPANTS included 1027 males from birth (cord blood) 69 yr. A subgroup followed up longitudinally infantile minipuberty [(in cord blood, and at 3...
Studies of adolescents often use self-assessment pubertal maturation, the reliability which has shown conflicting results. We aimed to examine child and parent assessments healthy boys girls.A total 898 children (418 girls, 480 boys, age 7.4-14.9 years) 1173 parents (550 daughters, 623 sons, 5.6-14.7 assessed onset puberty or development breasts, genitals, pubic hair according Tanner stages by a questionnaire drawings. Physicians' were blinded set as gold standard. Percentage agreement, κ,...
To construct new Danish growth charts for 0- to 20-year-olds and compare them with references from 1982 World Health Organization (WHO) standards children aged 0-5 years 2006, by applying similar inclusion exclusion criteria.Anthropometric data three contemporary population-based studies were combined. References height based on healthy Caucasian born at term. A total of 12,671 measurements (8055 in boys 4616 girls) included. Reference developed using the generalised additive models...
Most previous studies of 45,X/46,XY mosaicism are case reports or have described single aspects the disease. The objective was to provide longitudinal data patients with mosaicism. This a retrospective, study conducted from June 1990 January 2012. took place at tertiary pediatric and andrological referral center. Twenty-five (18 boys, seven girls) its variants were included compared healthy controls. No interventions in study. Phenotypes scored using external masculinization scores. Serum...
Summary Phthalates are a group of chemicals present in numerous consumer products. They have anti‐androgenic properties experimental studies and suspected to be involved human male reproductive health problems. A few shown associations between phthalate exposure changes pubertal timing among girls, although controversies exist. We determined the concentration 12 metabolites first morning urine samples from 725 healthy Danish girls (aged 5.6–19.1 years) relation age, development (breast pubic...
Few data exist on the diagnostic criteria, and effects of puberty induction, in boys with constitutional delay growth (CDGP). To develop nomograms based Danish normal pubertal development. evaluate different criteria effect oral testosterone undecanoate (TU) CDGP. A cross-sectional longitudinal study development (COPENHAGEN study). retrospective observational 451 evaluated for delayed between 1990 2013. Tertiary referral center pediatric endocrinology. One hundred sixty-four (36%) CDGP were...
In adult women, the circulating level of anti-Müllerian hormone (AMH) is a novel marker ovarian function, as it reflects number remaining follicles. Therefore, AMH has gained widespread attention in fertility clinics, and low believed to predict impaired imminent menopause. However, natural course levels during female childhood adolescence not known. Serum FSH were measured girls participating The COPENHAGEN Puberty Study. Longitudinal part: 85 healthy adolescents examined, blood samples...
Background Pubertal onset is usually defined by breast development in girls and testicular growth boys. Pubarche as the attainment of pubic hair considered a sign pubertal transition. preceded gradual increase production adrenal androgens, DHEA Δ4-androstenedione (Adione), process termed adrenarche. Objective To study natural course transition associations with adrenarche, body fat, linear growth. Design methods A longitudinal 179 healthy children (89 girls) higher socioeconomic background...
The majority of Turner syndrome (TS) patients suffer from accelerated loss primordial follicles. Low circulating levels anti-Müllerian hormone (AMH) may predict the lack spontaneous puberty in prepubertal girls and imminent premature ovarian insufficiency (POI) TS women with preserved function.To evaluate association between AMH status patients.Longitudinal observational cohort study.Tertiary referral center for pediatric gynecologic endocrinology.A total 120 patients, aged 0 to 48...
Ovarian function in Turner syndrome (TS) patients depends on the specific karyotype. This retrospective clinical study evaluates pituitary–gonadal axis during infancy, childhood and adolescence TS according to karyotype ovarian function. A cohort of 70 (0–16 years) followed at a tertiary referral centre for paediatric endocrinology were included. Longitudinal measurements reproductive hormones (FSH, LH, inhibin B estradiol) prior hormonal replacement treatment 66 related (A, 45,X; or B,...
Little is known about the possible deleterious effects of phthalate exposure on endogenous sex steroid levels in children.Our objective was to investigate whether urinary metabolite are associated with circulating adrenal androgen and age at puberty.This a longitudinal study 168 healthy children (84 girls) examined every 6 months for 5 years. Serum dehydroepiandrostenedione sulfate (DHEAS), Δ4-androstenedione, testosterone, morning excretion 14 metabolites, corresponding 7 different diesters...
Abstract Puberty marks numerous physiological processes which are initiated by central activation of the hypothalamic–pituitary–gonadal axis, followed development secondary sexual characteristics. To a large extent, pubertal timing is heritable, but current knowledge genetic polymorphisms only explains few months in inter-individual variation puberty. We have analysed longitudinal genome-wide changes DNA methylation peripheral blood samples (n = 102) obtained from 51 healthy children before...
Puberty is initiated by a complex interaction of suppressing and stimulating factors. Genetic studies familial central precocious puberty have suggested makorin ring finger protein 3 (MKRN3) as major inhibitor GnRH secretion during childhood. Furthermore, genetic variation near MKRN3 (rs12148769) affects age at menarche in healthy girls.The purpose this study was to evaluate whether serum levels declined before pubertal onset girls.This population-based longitudinal Danish girls cohort early...
Epidemiological evidence on maternal and paternal heritability of the wide normal variation within pubertal timing is sparse.We aimed to estimate impact parental onset puberty in boys girls.Annual examinations healthy children a longitudinal cohort study. Information (earlier, comparable to, or later compared peers) menarche age was retrieved from questionnaires.A total 672 girls 846 boys.Age at pubic hair (PH2+), breasts (B2+), girls; PH2+, genital stage (G2+), testis >3 mL with...
Abstract Analgesics which affect prostaglandin (PG) pathways are used by most pregnant women. As germ cells (GC) undergo developmental and epigenetic changes in fetal life PG targets, we investigated if exposure of rats to analgesics (indomethacin or acetaminophen) affected GC development reproductive function resulting offspring (F1) the F2 generation. Exposure either analgesic reduced F1 number both sexes altered tempo sex-dependently, with delayed meiotic entry oogonia but accelerated...
Several phthalates have been restricted/banned due to their adverse endocrine disrupting properties. The use of other and substitutes has increased. Here we examine the current exposure in family trios comprised infants parents exclusive breastfed following introduction a mixed diet.Metabolites 15 two substitutes, di(2-ethylhexyl)-teraphthalate (DEHTP) diisononyl-cyclohexane-1,2-dicarboxylate (DINCH), were measured urine samples collected from >100 paired 67 infants, while they exclusively...
Abstract Context The male hypothalamic-pituitary-gonadal (HPG) axis is transiently active during the first months of life with surging serum concentrations reproductive hormones. This period, termed minipuberty, appears to be essential for priming testicular function. Despite central role function, longitudinal data on HPG activation in infancy sparse. Objective To explore dynamics hormone activity healthy infants, assess association and volume, establish reference curves levels Design...
Minipuberty, a period of transient activation the hypothalamic-pituitary-gonadal (HPG) axis in both sexes, enables evaluation gonadal function infants suspected hypogonadism. However, female minipuberty remains poorly elucidated.
We previously reported that children of mothers who received fish oil supplementation during pregnancy had higher body mass index [BMI (in kg/m