A5073582175- Blood groups and transfusion
- Microfluidic and Capillary Electrophoresis Applications
- RNA Research and Splicing
- Erythropoietin and Anemia Treatment
- Forensic Toxicology and Drug Analysis
- Clinical Laboratory Practices and Quality Control
- Bladder and Urothelial Cancer Treatments
- Neurotransmitter Receptor Influence on Behavior
- Hemoglobinopathies and Related Disorders
- Urinary and Genital Oncology Studies
- Forensic Entomology and Diptera Studies
- Metabolomics and Mass Spectrometry Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Genomics and Rare Diseases
- Acute Myeloid Leukemia Research
- Biosimilars and Bioanalytical Methods
- Biosensors and Analytical Detection
- Innovative Microfluidic and Catalytic Techniques Innovation
- Iron Metabolism and Disorders
- Cannabis and Cannabinoid Research
- PARP inhibition in cancer therapy
- Thyroid and Parathyroid Surgery
- Extracellular vesicles in disease
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
Saint John Regional Hospital
2018-2024
Dalhousie University
2020-2023
Horizon Health Network
2018-2022
University of Alberta
2010-2012
Background Thyroid nodules are stratified through fine-needle aspiration (FNA) and often categorized using The Bethesda System for Reporting Cytopathology, which estimates the risk of malignancy six cytopathological categories. atypia undetermined significance (AUS) follicular lesion (FLUS) categories have varying rates reported in literature can range from 6 to 72.9%. Due this heterogeneity, we assessed rate effectiveness repeat FNA (rFNA) AUS/FLUS thyroid cytopathology at our institution....
Background Urinary cytology is routinely used in the diagnosis of urothelial neoplasms, with good sensitivity for high‐grade carcinoma (HGUC) but less so low‐grade neoplasm (LGUN). There significant interobserver and interinstitutional variability, especially atypical category. The Paris system reporting urinary (TPS) was introduced to better define various categories, cytology. Methods We retrospectively reviewed 630 atypia undetermined significance (AUS) cases reclassified them based on...
The implementation of next-generation sequencing (NGS) in routine clinical hematology practice remains limited. We evaluate the value NGS screening, diagnosis, and follow-up hematologic neoplasms.A targeted panel was used to assess a total 178 patients for questionable or previously diagnosed myeloid neoplasms.Gene variants were identified 53% patients. Novel 29% unknown significance 34%. Bone marrow samples yielded higher number than peripheral blood. is more sensitive test conventional...
The advent of inexpensive CO<sub>2</sub> laser systems has led to a wide range demonstrations microfabricated lab on chip built acrylic. However, there been little application these building microfluidics for DNA analysis. In this work we explore the use analysis and relate artifacts fabrication technology performance system. We show that surface roughness leads significant constrictions in separation channel provides an upper limit size can be analysed. Below limit, resolution is strongly...
Human erythropoietin (EPO) is an essential erythropoietic cytokine and recombinant biological therapeutic in anemia chronic kidney disease. Single nucleotide polymorphisms (SNPs) EPO have been linked to diabetic microvascular complications but no other cardiovascular comorbidities like dyslipidemia or hypertension. Here identified a clinical cohort of patients with anemia, dyslipidemia, hypertension, type-2 diabetes, heart failure preserved ejection fraction. Sanger sequencing was used for...
Abstract HbA1c is used in forensic toxicology to identify undiagnosed diabetes mellitus ( DM ) and those with poor glycemic control prior death. typically measured whole blood collected tubes containing ethylenediaminetetraacetic acid EDTA ). The effect of other additives, including sodium fluoride (NaF), unclear. Furthermore, the assessment short‐ long‐term stability has produced conflicting results. In this study, we paired postmortem samples NaF n = 142) assess their comparability for...
Introduction The inclusion of introns in the mature mRNA (intron retention), has been recently uncovered as a mechanism for regulation genetic expression vertebrates. Intron retention is implicated tissue specific protein diversity, splicing and control gene expression. We have identified intron involved erythropoietin (EPO) . EPO key regulator erythropoiesis transcriptionally regulated by hypoxia inducible factor 2 (HIF2). ability to easily detect could add our better understand genomes...