A5060542919- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of heterocyclic compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis and biological activity
- Synthesis and Reactions of Organic Compounds
- Synthesis and Reactivity of Heterocycles
- Multicomponent Synthesis of Heterocycles
- Synthesis of Organic Compounds
- X-ray Diffraction in Crystallography
- Synthesis and Characterization of Pyrroles
- Fluorine in Organic Chemistry
- Chemical Reaction Mechanisms
- Chemical synthesis and pharmacological studies
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- Crystallography and molecular interactions
- Organic Chemistry Cycloaddition Reactions
- Microwave-Assisted Synthesis and Applications
- Chemical Synthesis and Analysis
- Porphyrin and Phthalocyanine Chemistry
- Click Chemistry and Applications
- Nanomaterials for catalytic reactions
- Photochromic and Fluorescence Chemistry
- Synthesis and pharmacology of benzodiazepine derivatives
- Vibration Control and Rheological Fluids
N.D. Zelinsky Institute of Organic Chemistry
2010-2024
Irkutsk State University
2016-2024
Ural Federal University
2024
Russian Academy of Sciences
2008-2013
Abstract This review highlights methods for the synthesis of five- and six-membered heterocycles their annulated analogues. These are based on anionic domino reactions that have a common step: an SN2/Thorpe–Ziegler reaction. In addition, data biological activity these summarized. 1 Introduction 2 Synthesis Thiophenes, Pyrroles, Furans Other Heterocycles 2.1 3-Aminothiophenes 2.2 3-Aminopyrroles 2.3 3-Aminofurans 3 Bicyclic Heterocyclic Systems 3.1 Pyrroles Fused with Five-Membered 3.2...
A convenient one pot synthesis of 2,5-asymmetrically substituted thieno[2,3-b]thiophenes is developed. The method based on consecutive domino reactions (SN2 reaction → Thorpe-Ziegler reaction) using malononitrile and carbon disulfide as starting materials with the generation potassium 2,2-dicyanoethene-1,1-bis(thiolate) in a solution. high yield target thienothiophenes was achieved Ziegler dilution effect.
By using a quantum-chemical approach, B2PLYP-D2/6-311+G**//B3LYP/6-31+G*, we have carried out detailed study of the assembly 1-pyrrolines from N-benzyl-1-phenylmethanimine and phenylacetylene in superbasic medium KOtBu/dimethyl sulfoxide (DMSO). In this way, considered, both theoretically experimentally, mechanisms through concerted stepwise nucleophilic cycloaddition addressed side processes accompanying assembly. It is found that via kinetically more favorable than cycloaddition. At same...
Isothiazolothienopyridines have been prepared by a domino reaction (the SN2 → the Thorpe-Ziegler Thorpe-Guareschi type) from disodium 4-cyanoisothiazole-3,5-dithiolate. By changing order of addition alkylation reagents in with 4-cyanoisothiazole-3,5-dithiolate both possible isomers isothiazolothienopyridines are synthesized. These were further used three-component Knoevenagel Michael hetero-Thorpe-Ziegler to obtain wide range isomeric isothiazolothienopyranopyridines.
Merocyanine dyes of the dihydropyridine series were prepared from salts α(γ)-picolinium and cyanoacetic acid derivatives.Their spectral characteristics suggesting their structure in solution studied.The change properties depending on substituents introduced into solvents used (solvatochromism) was considered.The protonation studied, its regioselectivity established.
Abstract A new and facile three‐component method was developed for the synthesis of polymethylene‐3‐cyanopyridine‐2(1 Н )‐thiones by domino Knoevenagel → Michael heterocyclization dehydrogenation reaction from cycloalkanones, cyanothioacetamide, polymethoxy‐substituted benzaldehydes. The final step found to involve arylidenecyanothioacetamide. resulting pyridinethiones 4‐chloroacetoacetic ester were introduced into S N 2 Thorpe‐Ziegler Guareschi‐Thorpe synthesize tetracyclic...
Di(het)aryldiynes smoothly react with
Abstract The mechanism of 1‐azadienes formation from aldimines and arylacetylenes in the KO t Bu/DMSO superbasic medium has been explored theoretically using a DFT approach [B2PLYP(D2)/6‐311+G(d,p)//B3LYP/6‐31+G(d)] sophisticated model taking potassium tert ‐butoxide nearest solvation shell cation explicitly into account. main focus is placed on (i) detailed analysis kinetic thermodynamic characteristics isomerization intermediate propargylamine 1‐azadienes, (ii) factors determining isomeric...
Abstract A series of imidazothiazoles (ITZs) were conveniently accessed via an improved four‐step protocol in 55%–79% yields. The synthesized ITZs tested a combination phenotypic sea urchin embryo assay and PC‐3 human adenocarcinoma cytotoxicity studies. Both experimental approaches converged on compounds that showed microtubule targeting activity similar to the control compound, combretastatin CA‐4. Specifically, featuring electron‐donating pharmacophores position 4, including 4‐Me‐,...
Purpose . To investigate the influence of magnetic field on elastic characteristics isotropic elastomer. Methods The behavior particles in sample was studied based idea a hierarchical model chain formation combined with lattice particle arrangement. When studying systems aggregates, statistical distribution function introduced for number chain, which made it possible to calculate chains composite given concentration. nonlinear magnetization modeled form semi-empirical Frohlich-Kaenely law,...