The epidemiologic and immunologic findings for 104 subjects with subclinical Leishmania braziliensis infection were compared those 29 patients cutaneous leishmaniasis (CL) from the same area of endemicity. Subjects had a positive leishmania skin test result remained asymptomatic during next 4 years follow-up considered to have infection. Patients CL younger, larger-diameter indurations after testing, more likely serologic markers than (P <.05). In infection, levels interferon-γ tumor...

BackgroundSand fly saliva has an array of pharmacological and immunomodulatory components, immunity to protects against Leishmania infection. In the present study, we have studied immune response Lutzomyia intermedia saliva, main vector braziliensis in Brazil, effects pre-exposure on L. infection employing intradermal experimental model.Methodology/principal findingsBALB/c mice immunized with salivary gland sonicate (SGS) developed a saliva-specific antibody cellular presence both IFN-γ...

Inherited epidermolysis bullosa (EB) is a heterogeneous group of genetic disorders that present with skin and, in some cases, mucosal fragility, predisposing patients to the development blisters and/or erosions after minimal trauma or friction. Children recurrent history these kinds lesions neonates them absence another reasonable explanation should be investigated. Diagnosis must based on clinical and histopathological findings. To date, management inherited EB basically consists avoiding...

Abstract Background Obesity has been associated with the severity of psoriasis, but this relationship is not completely understood. Objectives This study aimed to evaluate associations between psoriasis and weight excess as determined using a variety parameters. Methods A cross‐sectional was performed in 296 patients. Their body mass index (BMI), waist circumference (WC), : hip ratio (WHR) values were compared results on area (PASI). Results The frequency severe higher men ( P &lt; 0.05)....

Abstract Purpose There is limited literature on the ocular manifestations in patients with psoriasis. Therefore, this study aimed to identify prevalence of and factors associated adults Methods This cross-sectional included Brazilian The dermatological evaluation diagnosis, clinical form, Psoriasis Area Severity Index (PASI) measurement, location lesions. Patients underwent a full ophthalmological examination, including Schirmer I test, Rose Bengala staining, tear breakup time tests. results...

Vitiligo is a muco-cutaneous, autoimmune, localized, or disseminated disease, which manifests through hypochromic achromic macules, with loss in quality of life. The prevalence vitiligo Brazil was determined to be 0.54%. There no on-label medication for its treatment. To date, Brazilian consensus on the treatment had been written. objective this group dermatologists experience disease reach clinical and surgical vitiligo, based articles best scientific evidence. Seven were invited, each...

Em 1993, um surto leishmaniose tegumentar americana (LTA) foi detectado no povoado rural de Canoa, município Santo Amaro, Bahia. Um estudo observacional prospectivo delineou-se, com objetivo determinar as taxas freqüência e caracterizar clinicamente a doença. Foram acompanhados 555 indivíduos, registrando-se 29 casos LTA, 11 sugestivos LTA pregressa 529 sadios. Desses sadios, 65 apresentaram reação Montenegro positiva sem qualquer evidência presente ou passada A prevalência período 5,2%...

Post-kala-azar dermal leishmaniasis (PKDL) is rarely reported in South America. In spite of the fact that there are many reports about association visceral and AIDS, PKDL very uncommon HIV-positive patients, so far only four cases have been documented literature. We present another case with unusual clinicopathological aspects. The patient, a 28-year-old male, from Salvador, Bahia (an endemic area) presented clinical manifestations three years after diagnosis AIDS. During treatment for he...

A psoríase acomete 0,12% a 0,71% da população infantil, sendo que forma eritrodérmica, grave e rara, ocorre em menos de 1,5% dos casos. Os antagonistas do Fator Necrose Tumoral-α (TNFα) constituem nova classe drogas, utilizada para tratamento moderada, refratária às terapias convencionais. O Etanercepte é uma proteína fusão receptor TNF-α, aprovada pelo Food and Drug Administration artrite reumatoide juvenil no grupo infantil. Apresentamos um caso criança com 7 anos idade, placa desde 8...

The present report describes a case of cutaneous protothecosis caused by Prototheca wickerhamii in non-immunocompromised female from the state Bahia, Brazil. This is second described Dermatological examination revealed diffusely infiltrated erythematous plaques on flexor aspect right arm and forearm. authors emphasize pathological aspects that can lead to misdiagnosis this condition. patient was successfully treated with fluconazole.

BACKGROUND: The current options for the treatment of acne vulgaris present many mechanisms action. For several times, dermatologists try topical agents combinations, looking better results. OBJECTIVES: To evaluate efficacy, tolerability and safety a topical, fixed-dose combination adapalene 0.1% benzoyl peroxide 2.5% gel in Brazilian population. METHODS: This is multicenter, open-label interventionist study. Patients applied 1.0 g on face, once daily at bedtime, during 12 weeks. Lesions were...

Post-kala-azar dermal leishmaniasis (PKDL) is rarely reported in South America. In spite of the fact that there are many reports about association visceral and AIDS, PKDL very uncommon HIV-positive patients, so far only four cases have been documented literature. We present another case with unusual clinicopathological aspects. The patient, a 28-year-old male, from Salvador, Bahia (an endemic area) presented clinical manifestations three years after diagnosis AIDS. During treatment for he...

Psoriasis is an immune-mediated disease that manifests predominantly in the skin, although systemic involvement may also occur. Although associated comorbidities have long been recognized and despite several studies indicating psoriasis as independent risk factor for cardiovascular events, little has done general medical practice regardind screening. In United States, less than 50% of clinicians are aware these recommendations.To identify prevalence 296 patients followed up at a university...

A queratose liquenoide crônica ou doença de Nekam é uma dermatose mucocutânea rara da queratinização, com curso crônico e progressivo, que acomete geralmente indivíduos entre 20 40 anos. Existem, aproximadamente, 70 casos descritos na literatura. Devido à raridade desta ausência tratamento efetivo, difícil manejo. No caso em questão, apresentamos um paciente 42 anos pápulas violáceas, hiperqueratósicas, algumas confluentes, aspecto linear, rendilhado placas, localizadas no tronco membros há...

Acquired cutis laxa (ACL) is a rare connective tissue disorder that affects the skin elastic fibers, resulting in loss of elasticity. In 50% cases, this condition associated with other diseases, particularly plasma-cell dyscrasias. This report describes case ACL unusual clinical and histopathological characteristics. A 29-year-old man presented diffuse erythematous plaques had first appeared 5 months previously. Examination revealed multiple flaccid on his trunk, neck, skinfolds....

Propionibacterium acnes (P. acnes) is one of the main microorganisms found on skin. It predominantly in hair follicles, prefers anaerobic condi...

BACKGROUND: Psoriasis is a chronic immune-mediated disease, characterized by increased levels of TNFα. Anti-TNFα agents have revolutionized the treatment severe psoriasis targeting an important molecule involved in its pathogenesis. OBJECTIVES: We report experience state referral center that uses anti-TNFα for psoriasis. METHODS: conducted retrospective case series. Seventy-four out 120 patients met inclusion criteria. Clinical and laboratory data was analyzed using chi-squared, Wicoxon...

A psoríase pustulosa generalizada é tipo raro de descrita pela primeira vez, em 1910, por Von Zumbusch. na criança tende a ter um curso mais benigno que no adulto, entretanto, sua forma grave, pode risco vida do paciente. Talvez, raridade da doença, nenhuma opção terapêutica se mostrou consistentemente eficaz e segura até o momento. Relatos isolados sugerem ser retinoide droga escolha nesses casos, porém trata-se fármaco que, infância, traz dificuldades manejo. Relata-se exemplo dessa rara...

Acne is a dermatological disease with high prevalence at adolescence that can worsen or even initiate serious psychological problems during an important phase of personality development. Several measures are available attempt to quantify the impact acne on quality life. There is, as yet, no ideal questionnaire, but need evaluate aspects in order develop correct therapeutic approach becoming ever more evident when we faced patient.