A5090566213- Tuberculosis Research and Epidemiology
- Healthcare Systems and Reforms
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Birth, Development, and Health
- Global Maternal and Child Health
- Pain Mechanisms and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Global Health and Surgery
- Nerve injury and regeneration
- Cancer Immunotherapy and Biomarkers
- Nuclear Engineering Thermal-Hydraulics
- Mental Health Treatment and Access
- Erythrocyte Function and Pathophysiology
- Diagnosis and treatment of tuberculosis
- Traditional Chinese Medicine Studies
- Mycobacterium research and diagnosis
- Cardiovascular Health and Risk Factors
- Toxin Mechanisms and Immunotoxins
- Antibiotic Use and Resistance
- Lung Cancer Research Studies
- Mobile Health and mHealth Applications
- Aging and Gerontology Research
- Plant-based Medicinal Research
- CAR-T cell therapy research
Duke Kunshan University
2021-2025
Wuhan University
2016-2025
Viva Biotech (China)
2022-2023
Second Affiliated Hospital of Jilin University
2023
Shenzhen Third People’s Hospital
2019-2022
Southern University of Science and Technology
2022
Institute of Urban and Regional Development
2012
Background Despite growing evidence of primary care-based interventions for chronic disease management in resource-limited settings, long-term post-trial effects remain inconclusive. We investigated the association a 12-month s ystem-integrated tech n ology- e nabled m odel c re (SINEMA) intervention with mortality outcomes among patients experiencing stroke at 6-year post-trial. Methods and findings This study (clinicltiral.gov registration number: NCT05792618) is passive observational...
Importance Despite evidence of the short-term benefits multicomponent primary care–based interventions, their long-term effects are unproven. Objective To evaluate outcomes a system-integrated technology-enabled model care (SINEMA intervention) for stroke management systolic blood pressure (BP) and other among patients with in China. Design, Setting, Participants This follow-up included community-dwelling clinically stable surviving participants an open-label cluster randomized clinical...
Abstract Background Inappropriate prescribing of medications and polypharmacy among older adults are associated with a wide range adverse outcomes. It is critical to understand the attitudes towards deprescribing—reducing use potentially inappropriate (PIMs)—among this vulnerable group. Such information particularly lacking in low - middle-income countries. Methods In study, we examined Chinese community-dwelling adults’ deprescribing as well individual-level correlates. Through...
Abstract Background There has been considerable progress in developing global health education and research China. Nevertheless, evidence of the Chinese universities’ contributions to is limited. More efforts are needed depict universities have collectively made advancing field health. This study aimed examine collective by describing longitudinal trends publications, uncovering themes health, exploring collaboration patterns. Methods A comprehensive bibliometric analysis was conducted for...
Immune checkpoint inhibitors (ICIs) play a significant anti‑tumor role in the management of non‑small cell lung cancer. The most broadly used ICIs are anti‑programmed death 1 (PD‑1), death‑ligand 1, and anti‑cytotoxic T lymphocyte‑associated antigen‑4 monoclonal antibody. Compared with traditional chemotherapy, have advantages greater efficiency more specific targeting. However, resulting immune‑related adverse events limit clinical application ICIs, especially inhibitor pneumonitis (CIP)....
The aim of this study was to analyze socioeconomic burdens and other difficulties that multidrug-resistant tuberculosis (MDR-TB) patients in cities are facing, identify major obstacles which groups most affected.Face-to-face phone-call interviews were conducted early 2018 follow-up with newly diagnosed MDR-TB 2017 three hospitals financially affluent Chinese cities. Demographic data information on their medical care, insurance coverage, expenses collected analyzed.A total 144 cases reviewed...
Current treatment options for diabetic neuralgia are limited and unsatisfactory. Tanezumab, a monoclonal antibody that blocks nerve growth factor (NGF) signaling, has been shown to be effective in relieving the clinical symptoms of osteoarthritis pain, chronic low back cancer pain induced by bone metastasis, neuralgia. However, development tanezumab terminated due risk induction rapidly progressive (RPOA), no other NGF antibodies have examined their ability treat either animal models or...
Dinutuximab (ch14.18) was the first approved monoclonal antibody against tumor-associated antigen disialoganglioside GD2. Despite its success in treating neuroblastoma (NB), it triggers a significant amount of neuropathic pain patients, possibly through complement-dependent cytotoxicity (CDC). We hypothesized that modifying ch14.18 using engineering techniques, such as humanization, affinity maturation, and Fc engineering, may enable development next-generation GD2-specific antibodies with...
Linezolid has been one of the key anti-tuberculosis agents for treatment multidrug-resistant tuberculosis (MDR-TB)/extensively drug-resistant (XDR-TB). It used to be very expensive and was not covered by social insurance from local governments. Nevertheless, a growing number patients in China received linezolid their anti- MDR/XDR TB regimens over past decade. Many scholars have reported experience using treat with MDR/XDR-TB. In view this, existing evidence efficacy safety problems faced...
The revised WHO guidelines on multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB) include linezolid in the core drug group. Common adverse events of prolonged use are bone marrow suppression and peripheral neuropathy (PN). Available measures against linezolid-induced PN (LIPN) often have insignificant effects, leading to discontinuation a decline success rate MDR/RR-TB treatment. Acupuncture treatment is symptomatic measure from traditional Chinese medicine (TCM) relieve pain with...
One of design features AP1000 is its passive safety system. As the newly designed system, performance under severe accidents causes a lot concerns. To prevent or minimize being uncovered core fuel during LOCAs, many researchers have devoted themselves to simulate LOCAs. In this paper, based on RELAP5, model was established and validated. LOCA simulations with different breaks were conducted, including LOCAs both cold leg hot break size 0.1 ft2 as 0.01%, 0.1%, 1%, 10%, 20%, 40%, 50% cross...
On the influence of "ritual", planning China ancient capitals showed unique and national characteristics. The layout usually pursued isomorphism with sky. It performed forms that, square shape, palaces in middle north cities, axial symmetry, left imperial ancestral temple right Country Altar, three courts five gates, front bedrooms behind, etc. These strategies still had continue to be used modern cities. Grid road system can bring out unit system. Both them benefit for cities dividing....
Abstract INTRODUCTION With the emergence of multi-drug resistant tuberculosis and threat it poses to public health, consequential cost involved in its treatment, constant effort has been put on evaluating improving patient care avoid treatment interference due impoverishment household.OBJECTIVE The aim this study was analyze socioeconomic burdens other difficulties MDR-TB patients cities are facing identify major obstacles which group most affected.METHODS Face-to-face phone-call interviews...
Abstract Background: We have witnessed considerable progress in developing global health education and research China. Nevertheless, evidence of the Chinese universities’ contributions to is limited. More efforts are needed depict universities collectively made advancing field health. This study aimed examine collective by describing longitudinal trends publications, uncovering themes health, exploring collaboration patterns. Methods: A comprehensive bibliometric analysis was conducted for...
Abstract Background: Inappropriate prescribing of medications and polypharmacy among older adults are associated with a wide range adverse outcomes. It is critical to understand the attitudes towards deprescribing—reducing use potentially inappropriate (PIMs)—among this vulnerable group. Such information particularly lacking in low - middle-income countries. Methods: The present study examined deprescribing individual-based characteristics that might be these community-dwelling China. We...
Abstract A growing body of literature suggests that early life circumstances can influence mental health throughout the lifespan. However, how these cumulatively contribute to depression in old age is not completely understood. The present study examined associations eight factors representing multifaceted experience at individual, family, and community levels with among community-dwelling older adults. Data were from China Health Retirement Longitudinal Study. We included 8,239 individuals...
Abstract Inappropriate prescribing of medications and polypharmacy among older adults could lead to avoidable harms. It is hence vital stop potentially inappropriate in this vulnerable group. An approach coined 'deprescribing' has been used describe a patient-centerd process optimizing medication regimens. But patient resistance discontinuing use significant barrier deprescribing. The present study aims attitudes towards deprescribing examine individual-based characteristics that might be...