A5102849028- Esophageal Cancer Research and Treatment
- Metabolomics and Mass Spectrometry Studies
- Gastric Cancer Management and Outcomes
- Reproductive Physiology in Livestock
- Advanced Proteomics Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Birth, Development, and Health
- Genetic and phenotypic traits in livestock
- Trace Elements in Health
- Muscle metabolism and nutrition
- Effects of Environmental Stressors on Livestock
- Cholesterol and Lipid Metabolism
- Gastrointestinal Tumor Research and Treatment
- Magnesium in Health and Disease
- MicroRNA in disease regulation
- Amino Acid Enzymes and Metabolism
- Adipose Tissue and Metabolism
- Milk Quality and Mastitis in Dairy Cows
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Iron Metabolism and Disorders
- Meat and Animal Product Quality
- Multiple and Secondary Primary Cancers
- Salivary Gland Disorders and Functions
- Invertebrate Immune Response Mechanisms
Shenyang Agricultural University
2025
Ministry of Agriculture and Rural Affairs
2025
Beijing Normal University
2023-2024
Tianjin Medical University Cancer Institute and Hospital
2018-2024
Huazhong Agricultural University
2021-2024
Chang'an University
2023
Development Research Center
2023
Zhoukou Normal University
2023
Intestinal epithelial cells (IECs) play crucial roles in forming an essential barrier, providing host defense against pathogens and regulating nutrients absorption. Milk-derived extracellular vesicles (EVs) within its miRNAs are capable of modulating the recipient cell function. However, differences between colostrum mature milk EVs their biological function attenuating intestinal injury remain poorly understood. Thus, we carried out present study to characterize difference milk-derived...
Significant physiological changes occur in both fetus and mother during pregnancy. Urine proteins have been shown to reflect a wide range of pathological the body. To comprehensively explore daily urine pregnancy, this study employed low-abundance protein-enriched magnetic nanobeads conduct an in-depth analysis throughout entire pregnancy rats. Based on 3,455 identified proteins, fetal maternal dynamic were observed group compared control group, including blastocyst formation cell division...
Reference methods for determining the contents of functional traits in camel milk are expensive and complex, hindering their widespread use. Mid‐infrared technology has advantages fast, economic, batch processing dairy detection. In present study, mid‐infrared spectroscopy ( MIRS ) prediction models previously established based on cow were used to predict 1101 Bactrian samples terms fat, protein, lactose, total solids, casein, β‐casein, K, Ca, Na Mg contents. The ‐predicted values 10 close...
Estrus is crucial for cow fertility in modern dairy farms, but almost 50% of cows do not show the behavioral signs estrus due to silent and lack suitable high-accuracy methods detect estrus. MiRNA exosomes play essential roles reproductive function may be developed as novel biomarkers detection. Thus, we analyzed miRNA expression patterns milk during effect on hormone secretion cultured bovine granulosa cells vitro. We found that number exosome protein concentration estrous were...
Can the urine proteome reflect short-term changes in growth and development of animals? Do developmental effects on urinary protein need to be considered when performing marker studies using model animals with faster growing periods? In this study, samples were collected from 10 Wistar rats aged 6-8 weeks 3 6 days apart. The results showed that could sensitively rats. For example, comparing Day 0 6, 195 differential proteins identified after screening (FC ≥ 1.5 or ≤ 0.67, P < 0.05), verified...
Background The tumor microenvironment plays an important role in the occurrence and development of tumors. However, there are gaps understanding molecular cellular interactions between cells immune (TME). aim this study was to identify a novel gene that played lung adenocarcinoma (LUAD). Methods expression profile clinical data for LUAD were downloaded from TCGA database. First, we used ESTIMATE algorithm evaluate stromal scores accordingly. Also, analyzed differentially expressed...
Introduction Magnesium (Mg) is an important mineral in living organisms. has multiple functions the human body, wherein it plays therapeutic and preventive role a variety of diseases. Methods Urine samples rats before after gavage magnesium L-threonate (MgT) were collected, urinary proteome was identified using LC-MS/MS technique analyzed various databases. Results discussion The results illustrated that significantly altered short-term intake supplements differential proteins biological...
Background: Retinoblastoma is currently the most common malignant tumor seen in newborns and children's eyes worldwide, posing a life-threatening hazard. Chemotherapy an integral part of retinoblastoma treatment. However, chemotherapeutic agents used clinics often lead to drug resistance. Thus there need investigate new chemotherapy-targeted agents. VEGFR3 inhibitors are anti-tumour-growth could be develop novel retinoblastoma-targeted Objective: To predict activity, discover influencing...
4048 Background: This study (NCT05476380) aimed to evaluate the safety and efficacy of neoadjuvant camrelizumab plus chemotherapy in patients with locally advanced ESCC, explore potential risk factors tumor immune microenvironment (TIM) which affect efficiency immunotherapy. Methods: Patients resectable thoracic staged as T1b-4a, N2-3 (≥3 stations), M0 or M1 lymph node metastasis (confined supraclavicular nodes) were enrolled. Eligible received intravenous (200 mg, day 2) paclitaxel (175...
Milk produced by dairy cows is a complex combination of many components. However, at present, changes in only few milk components (e.g., fat, protein, and lactose) during the estrus cycle have been documented. Mid-infrared (MIR) spectroscopy worldwide method routinely used for analysis, as MIR spectra reflect global composition milk. Therefore, this study aimed to investigate production traits (fat, lactose, urea, total solids (TS), solid not fat (SnF)) due estrus. Cows that were...
Objective: To explore whether urine proteome can reflect the difference between obese and normal weight people. Methods: Urine samples from people were collected identified by non-label quantitative proteomics using high performance liquid chromatography tandem mass spectrometry (LC-MS/MS). The proteins of screened for protein function biological pathway analysis. individuals was compared with that people, common differential counted to analyze pathways. Reported biomarkers obesity searched...
Abstract Video game addiction manifests as an escalating enthusiasm and uncontrolled use of digital games, yet there are no objective indicators for gaming addiction. This study employed mass spectrometry proteomics to analyze the proteomic differences in urine adolescents addicted compared those who do not play video games. The included 10 9 non-gaming a control group. results showed that were 125 significantly different proteins between two groups. Among these, 11 have been reported change...
Abstract Zinc is an essential element for maintaining normal physiological function in living organisms. In this study, the urine proteome of rats before and after short-term intragastric administration 82 mg/kg/d zinc gluconate (equivalent to 11.7 zinc) was compared analyzed. Many differential proteins have been reported be zinc-related, such as mucin-2 (MUC-2) (14 times with gavage, p = 0.005) transthyretin (3.9 gavage 0.0004). Biological processes enriched (e.g., regulation apoptosis...
Abtract Calcium is an essential element for maintaining the normal physiological function of organisms. In this study, 3225 mg/kg/d calcium gluconate (equivalent to 300 calcium) was intragastrically administered rats 4 days, and urine proteome analyzed. Many differential proteins have been reported be related, such as Regucalcin (2.6 times higher after gavage than before gavage, p = 0.022), transmembrane protein 132A (8.2 0.009), creatine kinase (17.5 0.006), claudin-3 (13.3 0.037)....
Abstract Iron is an essential trace element to maintain the normal physiological function of organisms. In this study, urine proteome rats before and after short-term intragastric administration polysaccharide-iron complex (28mg/kg/d iron, which equivalent dose anemia prevention in adults) was compared analyzed by using two analysis methods: individual comparison group comparison. Many different proteins were reported be related including 2’, 3’ -cyclic nucleotide -phosphodiesterase (CNPase)...
Abstract Do rats have corresponding changes in their urinary proteome when smelling different odors? In this study, urine samples were collected from six after sesame oil and essential balm for three days. And before on the third fourth Comparing protein groups of Day0 Day4 group, 143 differential proteins identified, average number randomly generated was 7.3, which means that about 95% could not be generated. such as low-density lipoprotein receptor-related 2 fetuin B, a biomarker COPD, are...
Abstract Objective To explore the possible effects on organism by analysing changes in urinary proteome of mice after autonomous consumption different sweet substances. Methods Urine samples were collected from C57BL/6l before and active The substances included sucrose, stevia glycosides, acesulfame, sucralose, which are more widely used worldwide can elicit a preference response mice, concentrations non-nutritive sweeteners chosen to be those that have been shown existing studies strongest...
To evaluate the efficacy and postoperative complications of endoscopic thoracoscopic laparoscopic radical esophagectomy compared to open surgery in esophageal cancer treatment. This retrospective study included 103 patients admitted from August 2018 March 2022, divided into observation (endoscopic surgery) control (open groups. We intraoperative parameters, outcomes, immune function, one-year overall survival (OS). Intraoperative bleeding volume, retention time chest tube, fasting time,...
Fourier Transform Mid-Infrared Spectroscopy (FT-MIRS) can be used for quantitative detection of milk components. Here, samples 458 Chinese Holstein cows from 11 provinces in China were collected and we established a total 22 prediction models fatty acids by FT-MIRS. The coefficient determination the validation set ranged 0.59 (C18:0) to 0.76 (C4:0). adopted predict 2138 new high-throughput computing software HiBLUP was employed construct multi-trait model estimate analyze genetic parameters...
Abstract The mortality rate of oesophageal squamous cell carcinoma (ESCC) remains high, and conventional TNM systems cannot accurately predict its prognosis, thus necessitating a predictive model. In this study, 17‐gene prognosis‐related gene signature (PRS) model was constructed using the random survival forest algorithm as optimal among 99 machine‐learning combinations based on data from 260 patients obtained TCGA GEO. PRS consistently outperformed other clinicopathological features...