A5023322506- Diabetes Treatment and Management
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Peptidase Inhibition and Analysis
- Free Radicals and Antioxidants
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Crystallization and Solubility Studies
- Inorganic and Organometallic Chemistry
- Cancer Immunotherapy and Biomarkers
- Nonlinear Optical Materials Research
- Chemical and Physical Properties in Aqueous Solutions
- Virus-based gene therapy research
- Carbohydrate Chemistry and Synthesis
- Analytical chemistry methods development
- Endometrial and Cervical Cancer Treatments
- Marine and fisheries research
- CRISPR and Genetic Engineering
- Ionic liquids properties and applications
- Porphyrin and Phthalocyanine Chemistry
- CAR-T cell therapy research
- Metal complexes synthesis and properties
- Respiratory Support and Mechanisms
Prince Mohammad bin Fahd University
2021-2025
Kings Health Partners
2024
Normandie Université
2023
University of Bath
2023
Indian Institute of Chemical Technology
2023
Academy of Scientific and Innovative Research
2023
Humboldt-Universität zu Berlin
2023
Central University of Punjab
2023
Central Drug Research Institute
2023
Indian Institute of Engineering Science and Technology, Shibpur
2023
A vertical array of five hydrophones was used to measure the acoustic field in plane singing humpback whales. Once a singer located, two swimmers with snorkel gear were deployed determine orientation whale and position boat so that could be front at minimum standoff distance least 10m. The spacing 7m deepest hydrophone depth 35m. An eight-channel TASCAM recorder bandwidth 24kHz record signals. location (distance depth) determined by computing time arrival differences between maximum source...
The study investigates the elemental composition and fungal contamination of commonly utilized spices herbs, namely Turmeric, Cloves, Black pepper, Latency/cumin, Ring/legume, Cinnamon, Coriander, Ginger, Indian saffron, Fenugreek, Fennel flower, Aniseed, Cayenne pepper. presence minerals poisons elements, including zinc (Zn), iron (Fe), chromium (Cr), manganese (Mn), copper (Cu), nickel (Ni), cadmium (Cd), lead (Pb), was examined. concentration poisonous elements ranged from 44.1±1.3 to...
In Experiment 1, rats were chronically infused with insulin (2.7, 27, or 270 ng/hr) 0.9% saline into the ventromedial (VMH), medial perifornical (PF), lateral (LH) hypothalamus. VMH infusions of caused a significant, dose-dependent decrease in food intake and body weight; PF infusion was less effective, but significant; whereas LH ineffective. 2, (0.54 VMH, paraventricular (PVN), posterior (PN) hypothalamic nucleus. Subjects that received PN failed to regain weight lost as result surgery...
The identification of potent, highly selective orally bioavailable ghrelin receptor inverse agonists from a spiro-azetidino-piperidine series is described. Examples this have promising in vivo pharmacokinetics and increase glucose-stimulated insulin secretion human whole dispersed islets. A physicochemistry-based strategy to lipophilic efficiency for potency retain low clearance satisfactory permeability while reducing off-target pharmacology led the discovery 16h. Compound 16h has superior...
The bioactive compound 2-Naphthylacetic Acid was the subject of theoretical experiments using DFT-B3LYP techniques with 6-311++G(d,2p) basis sets. Computational analysis included calculation Acid's geometrical parameters, molecular characteristics, and vibrational spectra. Density Functional Theory used to carry out optimizations. When calculated spectra optimized geometry were matched experimental results, significant agreement found. Furthermore, for aforementioned compound, DFT...
Peptidic glucagon antagonists have been shown to lower blood glucose levels in diabetic models (1-3), but attempts identify small molecular weight receptor-binding met with little success. Skyrin, a fungal bisanthroquinone, exhibits functional antagonism by uncoupling the receptor from adenylate cyclase activation rat liver membranes (1). We examined effects of skyrin on cells transfected human and isolated hepatocytes. The used was Talaromyces wortmanni American Type Culture Collection...
This study evaluated the contribution of isozymes cAMP phosphodiesterase (PDE) to total PDE activity in human and rat islets using type-selective inhibitors. The effects selected inhibitors on insulin secretion from were also measured order assess various modulation secretion. data suggest that III is quantitatively most important isozyme present islets, accounting for up 70% activity. Lower, but measurable, levels IV present. Approximately 20% islet not inhibitable by agents selective...
We examined the in vitro effects of CP 68722, a novel antidiabetic agent, 3T3-L1 adipocytes. 68722 stimulated 2-deoxyglucose uptake absence insulin. At least 30 min incubation were required for stimulation uptake. This effect increased over 5 h and was sustained up to 72 h. The by could be inhibited ∼60% inhibition protein synthesis with cycloheximide. Half-maximal maximal responses at observed 10 100 μM drug, respectively, threefold approximating response these cells acute insulin...
Inhibitors of the glucagon-like peptide-1 (GLP-1) degrading enzyme dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes in animal models and human subjects. A novel series cis-2,5-dicyanopyrrolidine alpha-amino amides were synthesized evaluated as inhibitors treatment diabetes. 1-({[1-(Hydroxymethyl)cyclopentyl]amino}acetyl)pyrrolidine-2,5-cis-dicarbonitrile (1c) is an achiral, slow-binding (time-dependent) inhibitor DPP-IV that selective over other...
We have used NMR in conjunction with measurements of functional bioactivity to define the receptor-binding structure glucagon-like peptide-1 (GLP-1.) Identification important residues for binding was accomplished by substitution amino acids at sites that seemed likely, from an examination acid sequence and previously published observations, be three-dimensional (3D) molecule. receptor-bound conformation GLP-1, because it is a flexible peptide, required constraint peptide backbone into...
Pyrogallol (1, 2, 3-trihydroxybenzene) was studied by computational study analysis using density functional theory (DFT), B3LYP method 6-311++G (d, p) as basis set. The done involving IR, UV–visible, H NMR and other parameters like, AIM (Atoms in molecules) for ellipticity, isosurface projection analysis, binding energies, which run parallel to experimental values. crystal intermolecular interactions were Hirshfeld surface donor acceptor NBO analysis. By also Fukui function Molecular...