A5026110207- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Esophageal and GI Pathology
- Diet, Metabolism, and Disease
- Hepatitis Viruses Studies and Epidemiology
- Alcohol Consumption and Health Effects
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Liver Diseases and Immunity
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Kidney Stones and Urolithiasis Treatments
- Bariatric Surgery and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Diet and metabolism studies
- Metastasis and carcinoma case studies
- SARS-CoV-2 and COVID-19 Research
- Bone health and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Endoplasmic Reticulum Stress and Disease
Hospital de Santa Maria
2008-2025
Universidade Federal Rural do Semi-Árido
2025
Instituto Português de Oncologia Francisco Gentil
2024
Centro Hospitalar Lisboa Norte
2014-2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024
Virginia Tech
2020
Institute of Electrical and Electronics Engineers
2020
City University of Macau
2019
University of Macau
2019
Canadian Standards Association
2019
To examine the morbidity of compensated cirrhosis type B, a cohort 349 Western European, white patients (86% men; mean age, 44 years) with biopsy-proven was followed up for period 73 months and studied occurrence hepatocellular carcinoma (HCC) decompensation. At entry into study all were tested hepatitis B e antigen (HBeAg; 34% HBeAg-positive) antibody to delta virus (anti-HDV; 20% anti-HDV-positive); 48% 252 (HBV)-DNA-positive. During follow-up HCC developed in 32 (9%) decompensation...
OBJECTIVES: The increasing incidence of nonalcoholic (NASH) and alcoholic steatohepatitis (ASH), associated with lack effective treatment, has prompted intensive studies on disease pathogenesis. Apoptosis is recognized as common in liver injury may also contribute to tissue inflammation, fibrogenesis, development cirrhosis. In this study, we identified mechanisms apoptosis induction human steatohepatitis, evaluated potential associations between apoptosis, pathology, clinical presentation...
Background/aims The pathogenesis of steatohepatitis remains largely unknown; however, bile acids may play a role as potential mediators liver damage. aim this study was to characterize acid profiles in tissue patients with steatohepatitis. Methods Bile composition determined by gas–liquid chromatography from nonalcoholic (NASH; n=15), alcoholic (ASH; n=14), and controls (n=8). Liver biopsies were graded for steatosis, inflammation, fibrosis. Results moderately increased compared (P<0.05)....
PURPOSE: The objective assessment of bone metastases is currently based on serial changes in skeletal survey. We performed a prospective study to determine whether correlation exists between the biochemical markers turnover and x-ray evaluation patients with or without bisphosphonate therapy, are influenced by extraskeletal disease. PATIENTS AND METHODS: Patients either were consecutively enrolled World Health Organization response criteria applied for both extraosseous disease every 3 4...
Objective: The aim of this study was to evaluate the incidence, prognostic factors and clinical significance delayed clearance serum HBsAg in compensated cirrhosis B. Methods: This a retrospective cohort 309 consecutive white patients with biopsy-proved type Results: During mean follow-up 68 months, loss occurred 32 patients, including 16 (8%) 196 untreated (mean annual incidence 0.8%), 8 (10%) 82 interferon (IFN) alpha–treated eight who had been treated other antivirals or steroids. 5-yr...
The objective assessment of bone metastases is currently based on serial changes in skeletal survey. We performed a prospective study to determine whether correlation exists between the biochemical markers turnover and x-ray evaluation patients with or without bisphosphonate therapy, are influenced by extraskeletal disease.Patients either were consecutively enrolled World Health Organization response criteria applied for both extraosseous disease every 3 4 months. Serum levels bone-specific...
•Two-dose vaccines increase Wuhan-Hu-1 IgG, IgM, and neutralisation levels in patients with CLD.•Cirrhosis, older age, type of vaccine predict lower IgG titres.•Compared Wuhan-Hu-1, humoral immunity was for the B.1.617 B.1.1.529 variants, all decreased after 6 months.•No major clinical or immune parameters associated SARS-CoV-2 infection rates efficacy. Background & AimsThe response chronic liver disease (CLD) to COVID-19 remains unclear. Our aim assess efficacy two-dose among CLD different...
ResumoA eclâmpsia é uma complicação grave dos distúrbios hipertensivos da gravidez, associada a significativa morbidade e mortalidade materna fetal. Sua gênese está relacionada à pré-eclâmpsia, caracterizada por hipertensão proteinúria após vigésima semana de gestação. Este estudo revisou avanços no manejo na prevenção eclâmpsia. A utilização do sulfato magnésio (MgSO4) para controle convulsões demonstrou eficácia, sendo complementada com agentes como labetalol hidralazina. Intervenções...
Objectives Apoptosis may play a role in the pathogenesis of alcoholic (ASH) and non-alcoholic steatohepatitis (NASH). In this study, we investigated modulation apoptosis-related liver proteins steatohepatitis. Methods Hepatocyte apoptosis was evaluated by TUNEL assay tissue 12 patients with NASH, ASH histologically normal controls. addition, caspase-3 processing immunoblot analysis. Expression death receptors, Bcl-2 family members, NF-κB inhibitor (IκB) were determined western blot. Liver...
Abstract: Introduction: Hepatocellular carcinoma is a leading cause of death from cancer worldwide. Survival patients depends on tumor extension and liver function, but yet there no consensual prognostic model. Aims: To evaluate the influence survival pretreatment parameters (clinico‐laboratorial, extension, Okuda Cancer Liver Italian program (CLIP) staging) treatment modalities. Methods: We retrospectively analyzed 207 patients, diagnosed between 1993 2003. The initial was: surgery – six...
AIMS: To evaluate the oxidative stress parameters before, during and after interferon treatment. PATIENTS/METHODS: Twenty patients were treated with α2b 5 MU, three times a week, subcutaneously, for 12 months. Liver biopsy was performed six months before treatment at month follow-up. Chromosomal breakage studies evaluated by adjusted clastogenic score (ACS, normal value [nv] 1.1±2.4%). Plasma malondialdehyde (MDA) measured according to Yagi method (nv 6.6±1.4 nmol/mL) total thiols using...
Clastogenic factors (CFs) are composed of lipid peroxidation products, cytokines and other oxidants with chromosome-damaging properties. They regularly observed after radiation exposure in chronic inflammatory diseases, where they supposed to be risk for carcinogenesis. It appeared interest investigate their presence the plasma patients hepatitis C.CFs detected by chromosomal breakage studies. were compared malondialdehyde (MDA), total thiols (t-SH), alanine aminotransferase (ALT), viral...
Colchicine, an inhibitor of collagen synthesis, has been suggested as potentially beneficial in cirrhosis.This long-term, randomized, double blind, placebo controlled trial was conducted order to evaluate the efficacy colchicine alcoholic cirrhosis.Ambulatory patients with biopsy proven cirrhosis, presenting from 1989 1997, no exclusion criteria (e.g. Child-Pugh C, bilirubin > 10 mg/dl and gastrointestinal bleeding previous 15 days), were randomized receive orally, 5 days/week, 1 mg/day or...