A5050264209- Cardiomyopathy and Myosin Studies
- Congenital heart defects research
- Congenital Diaphragmatic Hernia Studies
- Esophageal and GI Pathology
- Lymphatic Disorders and Treatments
- Hedgehog Signaling Pathway Studies
- Congenital Heart Disease Studies
- Renal and related cancers
- Signaling Pathways in Disease
- Congenital Anomalies and Fetal Surgery
- Cardiac Fibrosis and Remodeling
- Cardiac tumors and thrombi
- Vascular Malformations and Hemangiomas
- Cardiac Structural Anomalies and Repair
- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
- Force Microscopy Techniques and Applications
- Neurogenetic and Muscular Disorders Research
- Cellular Mechanics and Interactions
Osaka University
2022-2025
Kyoto Prefectural University of Medicine
2025
Social Insurance Saitama Chuo Hospital
2006
Saitama Medical University
2006
Restrictive cardiomyopathy (RCM) is characterized by impaired diastolic function with preserved ventricular contraction. Several pathogenic variants in sarcomere genes, including
Abstract Sonic Hedgehog ( Shh ), encoding an extracellular signaling molecule, is vital for heart development. null mutants show congenital disease due to left–right asymmetry defects stemming from functional anomaly in the midline structure mice. also known affect cardiomyocyte differentiation, endocardium development, and morphogenesis, particularly second field (SHF) cardiac progenitor cells that contribute right ventricle, outflow tract, parts of atrium. Despite extensive studies, our...
Restrictive cardiomyopathy in children is rare and outcomes are very poor. However, little information available concerning genotype-outcome correlations.We analyzed the clinical characteristics genetic testing, including whole exome sequencing, of 28 pediatric restrictive patients who were diagnosed from 1998 to 2021 at Osaka University Hospital Japan.The median age diagnosis (interquartile range) was 6 (2.25-8.5) years. Eighteen received heart transplantations 5 on waiting list. One...
Background Dilated cardiomyopathy (DCM) is a major cause of heart failure in children. Despite intensive genetic analyses, pathogenic gene variants have not been identified most patients with DCM, which suggests that cardiomyocytes are solely responsible for DCM. Cardiac fibroblasts (CFs) the abundant cell type heart. They several roles maintaining cardiac function; however, pathological role CFs DCM remains unknown. Methods and Results Four primary cultured CF lines were established from...
Abstract Down syndrome (DS) is the most prevalent chromosomal disorder associated with a higher incidence of pulmonary arterial hypertension (PAH). The dysfunction vascular endothelial cells (ECs) known to cause remodeling in PAH, although physiological characteristics ECs harboring trisomy 21 (T21) are still unknown. In this study, we analyzed human by utilizing isogenic pairs T21-induced pluripotent stem (iPSCs) and corrected disomy (cDi21)-iPSCs. T21-iPSC-derived ECs, apoptosis...
Restrictive cardiomyopathy (RCM) is a rare disease characterized by increased ventricular stiffness and preserved contraction. Various sarcomere gene variants are known to cause RCM; however, more than half of patients do not harbor such pathogenic variants. We recently demonstrated that cardiac fibroblasts (CFs) play important roles in inhibiting the diastolic function cardiomyocytes via humoral factors direct cell–cell contact regardless mutations. However, mechanical properties CFs...
Introduction: Patients with Down syndrome (DS) have a higher prevalence of pulmonary arterial hypertension (PAH). Pulmonary vascular endothelial dysfunction has been recognized to be one the predisposing factors develop PAH, but pathophysiology cells in DS specific PAH is still unknown. Hypothesis: Endothelial dysfunctions contribute developing DS. Methods: Induced pluripotent stem cell-derived (iPSC-ECs) from patients were utilized for analyzing cellular and mitochondrial functions. A...
Large fetal pleural effusion is a life-threatening abnormal finding. The objective was to study the efficacy of thoracoamniotic shunting with double-basket catheters by reviewing course and respiratory conditions neonates. Thirteen fetuses referred our hospital since 2003 2005 were reviewed. Abnormal findings in thorax noticed between 18 37 weeks gestation. Final diagnosises chylothorax 11 cases, chest wall mesenchymal hamartoma pulmonary sequestration effusion. Ten hydrops and/or ascites...