A5065259259- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Drug-Induced Adverse Reactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Epigenetics and DNA Methylation
- Vitamin D Research Studies
University of Padua
2010-2017
<h3>Background and aims</h3> Sarcoidosis is characterised by a compartmentalisation of CD4<sup>+</sup> T helper 1 (Th1) lymphocytes activated macrophages in involved organs, including the lung. Recently, Th17 effector cells have been claimed to be pathogenesis granuloma formation. The objective this study was investigate involvement sarcoidosis. <h3>Methods</h3> Peripheral pulmonary were evaluated flow cytometry, real-time PCR, immunohistochemistry analyses functional assays patients with...
// Antonella Teramo 1, 2, * , Gregorio Barilà Giulia Calabretto 2 Chiara Ercolin Thierry Lamy 3 Aline Moignet Mikael Roussel 4 Cédric Pastoret Matteo Leoncin 1 Cristina Gattazzo Anna Cabrelle Elisa Boscaro Sara Teolato Pagnin Tamara Berno Elena De March Monica Facco Francesco Piazza Livio Trentin Gianpietro Semenzato and Renato Zambello Padua University School of Medicine, Department Hematology Clinical Immunology Branch, Padua, Italy Venetian Institute Molecular Medicine (VIMM), Hematology,...
Background Blood and spleen expansion of immature myeloid cells (IMCs) might compromise the immune response to cancer. We studied in vivo circulating splenic T lymphocyte IMC subsets patients with benign malignant pancreatic diseases. ascertained vitro whether adenocarcinoma (PDAC)-associated are induced by tumor-derived soluble factors they immunosuppressive focusing on inhibitory co-stimulatory molecules PDL1 CTLA4. Methodology Principal Findings 103 and/or surgical were enrolled including...
To verify whether the dysregulation of CD4 T cells concurs in worsening outcome pancreatic cancer, we compared effects cancer and other gastrointestinal cell-conditioned media on (1) proliferation, migration, differentiation (2) expansion memory (CD45RO), naive (CD45RA), activated (CD69), regulatory (CD25) subsets.After culture control, (BxPC3, Capan1, MiaPaCa2), or (AGS, HepG2, HT29) media, evaluated interferon γ (IFNγ) production, CD45RA, CD45RO, CD69, CD25 membrane expression control...
Context An altered function of lymphocytes, DC and immature myeloid cells appears to be an hallmark tumor-mediated immune suppression the two inhibitory co-stimulatory receptors PDL-1 CTLA4 might have a role in this context. Objective The aim present vitro study was assess whether PaCa cross-talk with normal mononuclear circulating (PBMC) causing them acquire immunesuppressive phenotype evaluate PDL1 are involved. Methods PBMC from blood donors were cultured for 4 days control (CTL) cancer...