A5034002022- Moringa oleifera research and applications
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Phytochemicals and Antioxidant Activities
- Natural Compound Pharmacology Studies
- Pregnancy and preeclampsia studies
- Natural Antidiabetic Agents Studies
- Biochemical effects in animals
Institut du Thorax
2016-2023
Nantes Université
2016-2023
Centre National de la Recherche Scientifique
2016-2023
Institute Malgache De Recherches Appliquées
2023
Inserm
2014-2023
Centre Hospitalier Universitaire de Nantes
2017
Hypertension is characterized by a maintained high blood pressure leading to cardiac complications such as left ventricular hypertrophy and fibrosis an increased risk of heart failure myocardial infarction. This study investigated the effects oral administration Moringa oleifera (MOI) seed powder in spontaneous hypertensive rats (SHR). SHR received food containing MOI (750mg/d, 8 weeks) or normal food. In vivo measurement hemodynamic parameters telemetry structure function analysis...
Moringa oleifera (MOI) is a tree currently used in traditional medicine tropical Africa, America, and Asia for therapeutic applications several disorders including arterial hypertension. We previously described cardiac protective role of treatment with MOI seeds spontaneously hypertensive rats (SHR). Here, we investigated the effects this on oxidative nitrosative vascular stresses SHR, normotensive Wistar Kyoto as controls. Oxidative detected SHR aortas using fluorescent dye dihydroethidine...
Vascular aging is characterized by functional and structural changes of the vessel wall, including endothelial dysfunction, with decreased NO· bioavailability elevated vasoconstrictor inflammatory mediator production, vascular rigidity, tone impairment. Moringa oleifera (MOI) a little tree, different parts which are used in traditional medicine tropical Africa, America, Asia for therapeutic applications several disorders cardiovascular disease. The present study aimed at assessing effect MOI...
Vascular aging is linked to reduce NO bioavailability, endothelial dysfunction, oxidative stress, and inflammation. We previously showed that a 4-week treatment of middle-aged Wistar rats (MAWRs, 46 weeks old) with Moringa oleifera seed powder (MOI, 750 mg/kg/day) improved vascular function. Here, we investigated the involvement SIRT1 in MOI-induced improvement. MAWRs were treated standard or MOI-containing diet. Young (YWR, 16 controls received The hearts aortas harvested evaluate FOXO1...
Vascular ageing is characterized by functional and structural changes of the vessel wall, decreased endothelial NO bioavailability, elevated vasoconstrictor inflammatory mediators leading to dysfunction, vascular rigidity tone impairment. Moringa oleifera (MOI) a little tree used in Malagasy folk medicine treat cardiovascular diseases. The present study evaluated MOI treatment effects Wistar rats. Male rats (47 weeks old) received food containing 750 mg/kg/day seed powder or normal food. A...