A5030309363- Invertebrate Immune Response Mechanisms
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Hippo pathway signaling and YAP/TAZ
- Viral Infectious Diseases and Gene Expression in Insects
- DNA Repair Mechanisms
- Spine and Intervertebral Disc Pathology
- Gene Regulatory Network Analysis
- Cell death mechanisms and regulation
- Monoclonal and Polyclonal Antibodies Research
- Genetics, Aging, and Longevity in Model Organisms
- Autophagy in Disease and Therapy
- Telemedicine and Telehealth Implementation
- Hepatitis C virus research
- Cervical and Thoracic Myelopathy
- Genomics and Chromatin Dynamics
- Protein purification and stability
- Pharmaceutical Practices and Patient Outcomes
- Advanced biosensing and bioanalysis techniques
- Cancer-related Molecular Pathways
- Animal Genetics and Reproduction
Ho Chi Minh City International University
2022
Hallym University
2017-2021
HCMC Hospital of Dermato Venereology
2020
Rice University
2019
Boston University
2014
Introduction: Telepharmacy, the application of information and communication technologies in healthcare services, has been adopted many countries to provide patients with pharmaceutical care. However, it yet be widely used Vietnam. This study was conducted assess current status use factors associated willingness telepharmacy pharmacists Methods: A descriptive cross-sectional from February July 2021; 414 were recruited fill an online survey. Results: Overall, 86.7% participants have 87.2%...
Transposable selfish genetic elements have the potential to cause debilitating mutations as they replicate and reinsert within genome. Therefore, it is critical keep cellular levels of these low. This especially true in germline where could affect viability next generation. A class small noncoding RNAs, Piwi-associated responsible for silencing transposable most organisms. Several proteins been identified playing essential roles piRNA generation transposon silencing. However, part their...
Abstract The tumor suppressor p53 is involved in the DNA damage response and induces cell cycle arrest or apoptosis upon damage. Drosophila encodes two isoforms, p53A p53B , that induce somatic cells. To investigate roles of isoforms female germline cells, was analyzed adult ovary. Early oogenesis sensitive to irradiation lok -, hid -dependent death occurred rapidly after both low- high-dose irradiation. Both were responsible for this death. On other hand, delayed mid-oogenesis induced at a...
Claspin and TopBP1 are checkpoint mediators that required for the phosphorylation of Chk1 by ATR to maintain genomic stability. Here, we investigated functions Drosophila mus101 (TopBP1 ortholog) during chorion (eggshell component) gene amplification, which occurs in follicle cells absence global DNA replication.Unlike mei-41 (ATR mutant embryos, embryos showed severe eggshell defects resulting from amplification. EdU (5-ethynyl-2'-deoxyuridine) incorporation assay initiation elongation...
Abstract Hepatitis C virus (HCV) infection can be detected by using immunoassay techniques that measure reactivity to viral protein antigens. In this study seven discreet proteins derived from HCV genomic coding sequences have been expressed, purified and characterized. Six represent the structural regions of core (C22‐3), envelope (E1 E2), non‐structural NS3 (C33C), NS3–NS4 (C100‐3) NS5. The seventh, C25, is a chimeric fusion containing C33C, C100‐3 C22‐3 regions. Using these recombinant...
Synthetic hysteretic mammalian gene circuits generating sustained cellular responses to transient perturbations provide important tools investigate complex behaviors and reprogram cells for a variety of applications, ranging from protein production cell fate decisions. The design rules synthetic with controlled behaviors, however, remain uncharacterized. To identify the criteria achieving predictable control hysteresis, we built genetic circuit detection proteasomal degradation (Hys-Deg)....
ABSTRACT Ionizing radiation (IR) induces DNA double-strand breaks that activate the damage response (DDR), which leads to cell cycle arrest, senescence, or apoptotic death. Understanding DDR of stem cells is critical tissue homeostasis and survival organism. Drosophila hematopoiesis serves as a model system for sensing stress environmental changes; however, their remains largely unexplored. The lymph gland larval hematopoietic organ, where stem-like progenitors proliferate differentiate into...
Abstract In response to ionizing radiation (IR), stem cells undergo cell cycle arrest, senescence, premature differentiation, or death. The decision between survival and death is critical during tumorigenesis effective killing of cancer cells. We used the larval Drosophila lymph gland, a hematopoietic organ, as model understand mechanism for fate decisions development. progenitors survived died via apoptosis when larvae were irradiated in early late third instar (L3) stages, respectively. L3...