A5040520037- Hydrocarbon exploration and reservoir analysis
- Geological Studies and Exploration
- Paleontology and Stratigraphy of Fossils
- Geological formations and processes
- Geology and Paleoclimatology Research
- Geological and Geophysical Studies
- Geological and Geochemical Analysis
- Methane Hydrates and Related Phenomena
- Cancer Mechanisms and Therapy
- Geophysical Methods and Applications
- Lung Cancer Treatments and Mutations
- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Radioactive element chemistry and processing
- Geochemistry and Elemental Analysis
- PI3K/AKT/mTOR signaling in cancer
- Marine and environmental studies
- Maritime and Coastal Archaeology
- Petroleum Processing and Analysis
- Lung Cancer Research Studies
- Coronary Artery Anomalies
- Chronic Lymphocytic Leukemia Research
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Geomagnetism and Paleomagnetism Studies
University of the Highlands and Islands
2019-2024
University of Leeds
2024
University of Aberdeen
2010-2020
King's College Hospital
2010-2020
University of Exeter
2017-2018
Loxo Oncology at Lilly (United States)
2018
University of Cambridge
2013-2017
Array BioPharma (United States)
2004-2015
Institute of Geology and Geophysics
2012-2013
BackgroundAlterations involving the RET kinase are implicated in pathogenesis of lung, thyroid and other cancers. However, clinical activity multikinase inhibitors (MKIs) with anti-RET RET-altered patients appears limited, calling into question therapeutic potential targeting RET. LOXO-292 is a selective inhibitor designed to inhibit diverse fusions, activating mutations acquired resistance mutations.Patients methodsPotent activity, high selectivity, central nervous system coverage were...
Trace metal data for Proterozoic marine euxinic sediments imply that the expansion of nitrogen-fixing cyanobacteria and diversification eukaryotes were delayed while availability bioessential metals such as molybdenum in ocean was limited. However, there is increasing recognition Mesoproterozoic evolution nitrogen fixation eukaryotic life may have been promoted marginal terrestrial environments, including lakes, rather than deep ocean. Molybdenum critical to just it oceans. It is, therefore,...
Abstract The paleoenvironmental and paleogeographic development of the Norwegian–Greenland seaway remains poorly understood, despite its importance for oceanographic climatic conditions Paleocene–Eocene greenhouse world. Here we present analyses sedimentological paleontological characteristics deposits (between 63 47 million years old) in northeast Greenland, investigate key unconformities volcanic facies observed through seismic reflection imaging offshore basins. We identify uplift that...
Abstract Lake margin sedimentary systems can provide highly sensitive records of response to climate change. The Middle Old Red Sandstone Northern Scotland comprises a thick succession cyclic lacustrine sediments. Within this the deepest lake phase, Achanarras fish bed, allows bed‐scale correlation over 160 km across basin. This provides unique opportunity examine character synchronous deposits, and their climatically driven level fluctuations, large continental Detailed characterization two...
Complex environmental controls have influenced deposition of the Gråklint Beds, a prospective oil- and gas-prone Late Triassic (Mid-Carnian) source rock in Jameson Land Basin, East Greenland. The identification is significant for hydrocarbon exploration North Atlantic region. Detailed sedimentological analysis, biostratigraphy geochemical analysis provide insights into on development wider implications palaeoclimatic trends palaeogeographical reconstructions at this time. Beds were deposited...
Abstract: Continental lacustrine laminites deposited in low latitudes have been examined from the Devonian and Torridonian (Mesoproterozoic) strata of northern Scotland to investigate consistency sunspot periodicity through geological time. The thicknesses 2448 annual laminae were measured Middle ( c . 388 Ma) Achanarras Limestone Member, Lower Caithness Flagstone Group, 2821 Mesoproterozoic (1.2 Ga) Poll a'Mhuilt Member Stoer Group. Time-series analysis resolved periodicities 13.8 13.9...
Synopsis The Middle Old Red Sandstone (mid Devonian) of the Orcadian Basin in northern Scotland is composed predominantly cyclic lacustrine deposits. cyclicity recorded reflects regular fluctuations lake levels that have been attributed to climatic variability resulting from variations Earth's orbital parameters (Milankovitch cycles). However, previous estimates and calculations periodicities these events produced highly variable results, no consistent approach has emerged. Variability...
Fault block basins exposed along NE Greenland provide insights into the tectonic evolution of East and Norwegian-Greenland Sea. We present a new geological map cross sections Traill Ø region, Greenland, which formed western margin Vøring Basin prior to Cenozoic seafloor spreading. Observations support polyphase rift with three phases during Devonian–Triassic, Jurassic–Cretaceous, time. The greatest amounts faulting rotation occurred rifting, we correlate development continent-ocean...
Abstract During the Early Triassic Jameson Land Basin (Central East Greenland) was located around 30° N, in Northern arid belt, but by Jurassic positioned at a latitude of approximately 50° N. This study examines record this transition through largely continental succession using clay mineralogy, sedimentology, petrography and heavy mineralogy. The is aligned north–south 280 km long 80 wide. Following an marine phase basin filled predominantly sediments. Early‐to‐Late comprises coarse...
Detailed sedimentological examination of onshore sections through cyclic lacustrine deposits the Middle Devonian succession northern Scotland has been augmented with offshore data to allow construction a continuous 2.3 myr record orbital forcing. These provide an important climatic variance Devonian, which, by comparison other records from this time, can significantly improve our understanding global system. Precessional and eccentricity cycles are shown be dominant direct measurement...
Abstract The form of microbialite accumulations is largely the product environmental processes and microbial activity. Recent work has concentrated on identification classification microbialites with little attention being paid to their significance. This study describes distribution varied stromatolite forms recorded from Middle Old Red Sandstone sequences Orcadian Basin. Comparisons are made Triassic examples East Greenland modern accumulations. Northern Scotland was deposited in a...
The continental Triassic succession north of 72° in East Greenland has seen little investigation but is key understanding how facies belts vary towards the Shelf, and more widely North Atlantic region, through this period. This study presents sedimentological analysis exposures northern Traill Ø (the Mols Bjerge) further Geographical Society (Laplace Bjerg). These sections are correlated with studied which lies to south, Jameson Land broad scale palaeogeographical reconstructions presented....
Abstract Previous work has demonstrated the presence of a number exhumed hydrocarbon traps in central East Greenland. Re‐evaluation stratigraphy alongside detailed investigation occurrence bitumen within Mols Bjerge and Laplace Bjerg provides new perspectives on these structures, as well petroleum geology Greenland wider North Atlantic. Sedimentological stratigraphic studies, augmented with palynological provenance investigations, have constrained dating correlation strata exposed Bjerg....
Abstract Background: Activating mutations and oncogenic fusions of the RET receptor tyrosine kinase have been identified in multiple tumor types, including thyroid, lung, breast colon carcinoma. Furthermore, inhibitors (TKIs) with anti-RET activity produced clinical responses patients whose tumors harbor alterations. However, currently available were initially developed to target kinases other than are only moderately potent against RET, inhibit or poorly secondary resistance (e.g....
Abstract The Boltysh meteorite impact crater, Ukraine, formed at the Cretaceous–Palaeogene boundary ca 65·2 Ma. A borehole drilled in central part of crater cored a >400 m thick high‐resolution lacustrine succession that covers Dan‐C2 hyperthermal event associated with negative carbon isotope excursion. Continuous terrestrial records past hyperthermals are limited availability, which makes this record unique case study continental rapid climate warming. This uses sedimentological core log...
Abstract The Triassic of the Central North Sea is a continental succession that contains prolific hydrocarbon-bearing fluvial sandstone reservoirs stratigraphically partitioned by mudstones. Within Skagerrak Formation UK sector, hydrocarbon accumulations in Judy, Joanne and Josephine Sandstone members are top sealed Julius, Jonathan Joshua Mudstone members, respectively. However, Norwegian stratigraphic correlations have been problematical for decades, largely due to biostratigraphic...
Abstract Lake margin sedimentary systems have been the subject of only limited study. The cyclic Middle Devonian lacustrine succession Northern Scotland contains repeated developments shore zone sandstones and thus provides an ideal location for study these units. cycles comprise deep lake, shallow playa facies. Detailed field observations are presented alongside ground penetrating radar data which has aided large‐scale three‐dimensional characterization sand bodies. Loading discrete channel...
Abstract In this study, single-grain mineral geochemistry, detrital zircon geochronology, and conventional heavy-mineral analysis are used to elucidate sediment transport pathways that existed in the North Atlantic region during Triassic. The presence of lateral axial drainage systems is identified their source regions constrained. Axial suggested have likely delivered sourced East Greenland (Milne Land–Renland) as far south Viking Graben (>800 km). Furthermore, data highlight...
Permian to Triassic outcrops in East Greenland diminish significantly northwards. Understanding the northward extent, and nature, of successions has implications for regional palaeogeographic reconstructions exploration adjacent offshore basins. Examining structural relationships between basement, Permian, Triassic, Jurassic Cretaceous can further our understanding tectonic evolution region. Here, we describe a hitherto overlooked section through from central Wollaston Forland consider its...
The aim of this study is to elucidate the character earliest phases Jurassic rifting in North-East Greenland. To achieve this, detailed sedimentological analysis and geological mapping were undertaken on outcrops central Kuhn Ø (74°53’55’’N,20°20’56”W). In region basement overlain by fluvial Bastians Dal Formation (Middle Jurassic) which is, turn, coal-bearing Muslingebjerg Formation. A maximum thickness 140 m calculated for stratal geometries demonstrates thinning both north south,...
Abstract The Jameson Land Basin lies within the Greenland–Norway rift, to south of Triassic basins on Halten Bank and East Greenland shelf, can therefore offer insights into development these less-well-documented offshore wider North Atlantic. This study focuses stratigraphic Basin. Broad-scale logging is augmented with heavy mineral analysis that constrains dominant source catchments during this period. A thickness over 1.5 km Middle–Late strata fill Basin, predominantly comprising...
Abstract Background: The fibroblast growth factor receptor (FGFR1-4) family of tyrosine kinases plays an important role in normal physiologic processes, including angiogenesis, wound healing and regulation calcium phosphate metabolism. In addition, dysregulation FGFR signaling through genetic alterations or altered expression individual receptors their ligands has been frequently observed human tumors. While kinase inhibitors (TKIs) with anti-FGFR activity have produced clinical responses...