A5024806732- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Cholinesterase and Neurodegenerative Diseases
- Lower Extremity Biomechanics and Pathologies
- Pain Mechanisms and Treatments
- Advanced Glycation End Products research
- Inflammasome and immune disorders
- Plant chemical constituents analysis
- Genomics, phytochemicals, and oxidative stress
- Natural Antidiabetic Agents Studies
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Renin-Angiotensin System Studies
- Nicotinic Acetylcholine Receptors Study
- Neurological Disorders and Treatments
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Free Radicals and Antioxidants
- Neuroinflammation and Neurodegeneration Mechanisms
- Hormonal Regulation and Hypertension
Volgograd State Medical University
2022-2025
Исследование новых противосудорожных фармакологических веществ с потенциальным болезнь-модифицирующим действием является актуальной задачей при создании более эффективных методов лекарственного лечения эпилепсии. Изучена противосудорожная активность фторбифенилзамещенных имидазо[1,2-a]бензимидазолов — соединений BIF-70 и BIF-72 в тесте «Максимальный электрошок» у мышей модели спонтанных рецидивирующих судорог, индуцированных пилокарпином (320 мг/кг), крыс. В соединение (20 мг/кг...
We have synthesized new melatonin analogs 4,6,11,12 based on 3-hydroxy-2-oxindoles (11) and hydroxy-free 2-oxindoles (4,6,12) evaluated their neuroprotective antioxidant properties as well ability to reduce intraocular pressure. Reductive amination was used obtain 5-(benzylamino)-substituted (indolin-3-yl)acetonitriles 11 (indolin-3-yl)acetic acids 12 with high yields. Compounds 4a,c, 6a 11a,d,h,j-l demonstrated IOP reduction effect in range 15-27% similar the of reference compounds timolol...
Key biomolecular targets involved in regulating neuronal excitability are discussed, and recent findings on benzimidazole derivatives exhibiting anticonvulsant activity presented. The relationship between their structure is closely analyzed. literature review revealed that benzimidazoles possess diverse biological activities significant potential for modulating ion channels, receptors, other implicated epileptogenesis, making them a promising scaffold the development of novel antiepileptic...
Introduction: Kappa-opioid receptor (KOR) signaling in the basolateral amygdala (BLA) underlies KOR agonist-induced aversion. In this study, we aimed to understand individual and combined effects of agonist U-50488 p38 MAPK inhibitor SB203580 on spiking activity pyramidal neurons BLA shed light complex interplay between KORs, MAPK, neuronal excitability. Materials Methods: Electrophysiological experiments were performed using patch-clamp technique whole-cell configuration. Rat brain slices...
Type 2 diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia, inflammation, impaired insulin secretion, and/or peripheral resistance. Current α‐glucosidase inhibitors approved for clinical use exhibit limited efficacy compared to other glucose‐lowering agents. In this study, series of mono‐ and bis‐benzylidene derivatives were synthesized via aldol condensation 3‐oxo‐dammarane triterpenoids with terephthalic aldehyde. The target derivatives, based on the...
The study is focused to the investigation of a new kappa-opioid agonist RU-1205, which exhibits an analgesic effect without causing dysphoric or aversive actions. It assumed that this effects may be due its functional selectivity, presence additional mechanism action involves blocking p38 mitogen-activated protein kinase (MAPK). aim was experimental identification RU-1205 mechanisms associated with inhibition MAPK and selectivity for kappa opioid receptors. Materials methods. LFP activity...
Background . Schizophrenia is a socially signifi cant disease that takes variety of forms. The form the course determines prescribing antipsychotic drugs with different range clinical effects. study pharmacological activity neuroleptics involves an experimental model using animals which makes it possible to reproduce some aspects schizophrenia. Objectives aimed at evaluating 5-HT2A— RU-31 antagonist and atypical neuroleptic clozapine in behavioral tests electroencephalography (EEG). Methods....
Since ischemic stroke is an extremely common and dangerous pathology, it important to use drugs with neuroprotective activity. The depth degree of brain damage due ischemia are reflected in its bioelectrical This makes possible the electrocorticography or intracranial electroencephalography (EEG) as a tool for evaluating effectiveness therapy. In present study properties experimental compound RU-1205 kappa-opioid agonist butorphanol were analyzed. effect substances was assessed by measuring...
Animal modeling of schizophrenia is essential for understanding the neurobiological basis disease, as well development new antipsychotic drugs with improved therapeutic efficacy and safety profile. The review aims at summarizing methodology practical aspects based on dysontogenetic disturbances central nervous system in rats mice. Environmental factors or destruction brain structures during prenatal postnatal periods cause reorganization neural networks, leading to irreversible changes...
This study focuses on RU-1205, a new kappa-opioid agonist exhibiting analgesic effect without causing dysphoric or aversive reactions. It is assumed that the absence of effects can be attributed to functional selectivity it might due an additional mechanism action involves blocking p38 mitogen-activated protein kinase (MAPK). The aim this was experimental identification mechanisms RU-1205 associated with inhibition MAPK and at receptors. Materials methods Rats weighing 260-280 g were...
Introduction. The anatomical features of the knee joint are significant as potential predictors various diseases and injuries. However, relationship between position ACL structural parameters remains insufficiently studied. This work aims to identify statistically correlations individual their association with topography within joint. Purpose study . To determine relationships impact on positioning ACLin based MRI data. Materials methods. involved analysis images 391 from patients different...
The development of new drugs to combat neuroinflammation is highly relevant as it opens up possibilities for the treatment a wide range diseases, including Alzheimer’s disease, Parkinson’s epilepsy, schizophrenia, depression, and others. Kappa-opioid agonists represent promising class compounds with а high potential be used in neurological conditions accompanied by neuroinflammation. aim study was provide summary current strategies employed evaluate neurotropic anti-inflammatory effects...
Schizophrenia is a chronic psychoneurological condition that encompasses wide variety of neurochemical, morphological, bioelectrical and behavioural changes. Comprehension the mechanisms underlying schizophrenia psychosis cannot be fully acquired in clinical studies with humans. For this reason, number experimental animal models have been developed. Although none existing reproduces complete spectrum schizophrenia, critical aspects pathology processes can experimentally recapitulated. In...
Introduction: Among the various receptor systems in brain, opioid receptors have been subject of extensive research due to their integral role pain modulation, reward processing, and emotional regulation. The kappa-opioid (KOR) system, particular, stands apart its unique contribution stress response, aversive behaviors, dysphoric states. This paper aims provide an understanding neural activity underlying aversion-associated effects KOR agonist U-50488.
 Materials Methods: Rats underwent...
Drug-target interaction (DTI) prediction has become a foundational task in drug repositioning, polypharmacology, discovery, as well resistance and side-effect prediction. DTI identification using machine learning is gaining popularity these research areas. Through the years, numerous deep methods have been proposed for Nevertheless, accuracy efficiency remain key challenges. Pharmaco-electroencephalogram (pharmaco-EEG) considered valuable development of central nervous system-active drugs....
Machine learning methods are starting to be widely used in the analysis of neuroimaging data. Apart from playing a crucial part development Brain-Computer Interface technologies, machine can also academic context link cognitive phenomena their neurophysiological sources. In this study we attempted use SVM model classify fragments MEG recording according semantic categories words that were presented subject at moment. The preprocessed data was clustered spatial and temporal domains clusters...