A5071496036- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Catalytic C–H Functionalization Methods
- Catalytic Alkyne Reactions
- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Oxidative Organic Chemistry Reactions
- Marine Sponges and Natural Products
- Cyclopropane Reaction Mechanisms
- Microbial Natural Products and Biosynthesis
- Organometallic Complex Synthesis and Catalysis
- Radical Photochemical Reactions
- Organoboron and organosilicon chemistry
- Molecular spectroscopy and chirality
- Organ Transplantation Techniques and Outcomes
- Chemical Synthesis and Reactions
- Carbon dioxide utilization in catalysis
- Hepatitis B Virus Studies
- Nuclear Materials and Properties
- Axial and Atropisomeric Chirality Synthesis
- Chemical Synthesis and Analysis
- Luminescence and Fluorescent Materials
Janssen (Belgium)
2024-2025
Torrey Pines Institute For Molecular Studies
2020
Scripps (United States)
2020
Scripps Institution of Oceanography
2020
Scripps Research Institute
2018
Charles Humbert 8
2017
École Polytechnique Fédérale de Lausanne
2015-2017
Heidelberg University
2012
Application of chiral derivatives the versatile and ubiquitous cyclopentadienyl ligand has long remained an underdeveloped area in asymmetric catalysis. In this Perspective we highlight recent exciting results that demonstrate their enormous potential. particular, provide a comparative analysis available families, overview complexation chemistry, examination application catalytic enantioselective reactions. We also discuss current limitations speculate on developments are necessary to...
Abstract Vinyl triazenes were obtained by enantioselective [2+2] cycloaddition reactions of bicyclic alkenes with 1‐alkynyl in the presence a Ru II catalyst chiral cyclopentadienyl ligand. These serve as unique vinyl cation surrogates. Under acidic conditions, triazene functionality can be replaced variety groups, including halides, alkoxides, sulfoxides, amides, arenes, and heteroarenes, thus providing efficient access to pool polycyclic compounds.
The cyclopentadienyl (Cp) group is a ligand of great importance for many transition-metal complexes used in catalysis. Cationic CpRu(II) with three free coordination sites are highly versatile catalysts atom-economic transformations. We report the synthesis family Cp(x)Ru(II) chiral Cp ligands keeping maximum number available sites. cationic members efficient and selective yne-enone cyclizations via formal hetero-Diels-Alder reactions. transformation proceeds <1 h at -20 °C provides pyrans...
A chiral version of the Cp*Ru(COD)Cl complex equipped with an atropchiral cyclopentadienyl (Cp<sup>x</sup>) ligand enables [2+2]-cycloadditions between bicyclic olefins and alkynes excellent reactivity enantioselectivity. streamlined synthesis Cp<sup>x</sup> by a C–H functionalisation approach is shown. The chloride counterion neutral Cp<sup>x</sup>Ru<sup>II</sup> essential for
The intriguing structure of tagetitoxin (1), a long-standing challenge in natural product synthesis, has been the subject multiple revisions and confirmed through total synthesis. route commences from renewable furan starting material features number unusual transformations (such as rearrangements, bromocyclization, P(V)-based phosphate installation) to arrive at target 15 steps. As was designed enable access both enantiomers, absolute configuration could be assigned using bioassay on (+)-1 (−)-1.
Abstract Vinyl triazenes were obtained by enantioselective [2+2] cycloaddition reactions of bicyclic alkenes with 1‐alkynyl in the presence a Ru II catalyst chiral cyclopentadienyl ligand. These serve as unique vinyl cation surrogates. Under acidic conditions, triazene functionality can be replaced variety groups, including halides, alkoxides, sulfoxides, amides, arenes, and heteroarenes, thus providing efficient access to pool polycyclic compounds.
The first total synthesis of the polyketide apiosporic acid is presented. Key steps are a Julia-Kocienski olefination, Suzuki-Miyaura cross-coupling, and an intramolecular Diels-Alder reaction. absolute configuration natural product was determined.
Ruthenium complexes, in particular cyclopentadienyl ruthenium (<small>ii</small>) derivatives, catalyze a vast number of transformations the field homogenous catalysis. Herein we describe first synthesis efficient chiral cationic catalysts and their application enantioselective cycloisomerizations yielding 4H-pyrans. A tremendous counterion effect on selectivity was observed subsequently explored, giving rise to complementary set neutral complexes able asymmetric cyclobutene formations.
Abstract Review: [40 refs.
Abstract The preparation of twelve title complexes is described.
Cyclopentadienyl ruthenium(II) complexes are an important class of homogenous catalysts. They engage in a multitude different transformations, for example cycloisomerizations. Due to lack suitable chiral cyclopentadienyl ligands, no efficient enantioselective version the cationic CpRu(MeCN)3PF6 catalyst had been developed past, despite synthetic needs and potential. This thesis describes general synthesis CpxRu(II) An atropchiral C2-symmetric biaryl ligand scaffold proved be most allows...