A5070288472- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radical Photochemical Reactions
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Oxidative Organic Chemistry Reactions
- Chemical synthesis and alkaloids
- Catalytic Alkyne Reactions
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Reactions
- Synthetic Organic Chemistry Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Crystallography and molecular interactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cyclization and Aryne Chemistry
Université de Strasbourg
2021-2024
Centre National de la Recherche Scientifique
2019-2024
Université de Haute-Alsace
2021-2024
Université Paris Cité
2019-2022
Observatoire de Paris
2020-2021
Délégation Ile-de-France Villejuif
2020
Carbon–carbon bond formation reactions are of longstanding interest in organic chemistry. Improvements the methods targeting its creation still being performed, especially thanks to development innovative methodologies transition metal catalysis and photocatalysis. This review will tackle combination photoredox cycles create carbon–carbon bonds, focusing on four metals most reported literature this domain: Ni, Pd, Au Cu.
Abstract Regiodivergent reactions are a fascinating tool to rapidly access molecular diversity while using identical coupling partners. We have developed new approach for regiodivergent synthesis the dual character of hypervalent bromines. In addition recently reported reactivity bromines as aryne precursors, first transition metal‐catalyzed reaction is reported. Accordingly, development these two complementary transformations allows alteration regioselectivity furnish both ortho ‐ and meta‐...
Polyhalogenated biaryls are unique motifs offering untapped potential as versatile building blocks for the expedient synthesis of complex biaryl compounds.
Biaryls have widespread applications in organic synthesis. However, sequentially polysubstituted biaryls are underdeveloped due to their challenging preparation. Herein, we report the synthesis of dissymetric 2,3,2',3',4-substituted via pericyclic reactions cyclic diaryl λ3-bromanes. The functional groups tolerance and atom economy allow access molecular complexity a single reaction step. Continuous flow protocol has been designed for scale-up reaction, while postfunctionalizations developed...
An efficient silver-catalyzed tandem reaction for the formation of 1,2-dihydroisoquinoline derivatives is herein reported. Highly functionalized multiheterocyclic scaffolds are accessible in a straightforward manner using readily starting materials under mild conditions. This methodology offers an attractive route synthesis and development biologically relevant new heterocyclic pharmacophore, merging biological activities isoquinolines with those various nitrogen-containing heterocycles...
Rearrangement reactions in organic chemistry are attractive strategies to build efficiently complex scaffolds, just one step, from simple starting materials. Among them, aryl migrations certainly of the most useful and straightforward rearrangement for building carbon–carbon bonds. Of note, anionic migration have been largely described compared their radical counterparts. Recently, visible-light catalysis has proven its efficiency generate such rearrangements due concomitant loss a particle...
Abstract Phosphoramidates are for the first time presented as efficient N‐Centered Radical (NCR) precursors under visible‐light irradiation. More precisely among this class of phosphorus‐derived compounds, we studied radical reactivity phosphonohydrazones, mild reaction conditions, which allowed synthesis a wide and diversified library scarcely reported phthalazine scaffold. Mechanistic investigations confirmed formation NCR from these brand‐new phosphonohydrazones (derivatived...
N-Containing heterocycles are important scaffolds due to their ubiquitous presence in bioactive compounds. Their synthesis has been considered as an research field. In this work we report the access 6- and 7-membered rings via a photoinduced strategy. To our knowledge, represents first exemple of photo-induced 7-endo-trig cyclization with N-centered radicals.
Abstract Regiodivergent reactions are a fascinating tool to rapidly access molecular diversity while using identical coupling partners. We have developed new approach for regiodivergent synthesis the dual character of hypervalent bromines. In addition recently reported reactivity bromines as aryne precursors, first transition metal‐catalyzed reaction is reported. Accordingly, development these two complementary transformations allows alteration regioselectivity furnish both ortho ‐ and meta‐...