Hydrogels are cross-linked polymeric networks, which have the ability to hold water within spaces available among chains. The hydrogels been used extensively in various biomedical applications, e.g., drug delivery, cell carriers and/or entrapment, wound management and tissue engineering. Though far from extensive, this article has devoted study common methods for characterization of review range applications same health care.

The purpose of this study was to investigate the feasibility entrapping water-insoluble drug itraconazole into solid lipid nanoparticles (SLNs) for topical ocular delivery. drug-loaded SLNs were prepared from stearic acid and palmitic using different concentrations polyvinyl alcohol employed as emulsifier. by melt-emulsion sonication low temperature-solidification method characterized particle size, zeta potential, loading entrapment efficiency. mean size with ranged 139 199 nm, while had in...

Background: Particulate systems have received increasing attention for oral delivery of biomolecules. The objective the present study was to prepare submicron particulate formulations papain pH-dependent site-specific release using pH-sensitive polymers. Methods: Enteric particle were prepared by w/o/w emulsion solvent evaporation hydroxypropyl methylcellulose phthalate (HPMCP), Eudragit L100, and S100, avoid gastric inactivation papain. Results: Smaller internal external aqueous phase...

Abstract The intake of omega‐3 unsaturated fatty acids has a beneficial effect on insulin sensitivity in rats and subjects with type 2 diabetes. It been reported that these are useful the treatment hypertriglyceridemia enhancement high‐density lipoprotein (HDL)‐cholesterol levels diabetic patients. present study was therefore aimed to evaluate antioxidant, antihyperglycemic antihyperlipidemic L. usitatissimum fixed oil. antioxidant activity evaluated vitro using 1,1‐diphenyl‐2‐picryl...

In the current study, polylactide-co-glycolide (PLGA) nanoparticles entrapping both clozapine (CLZ) and risperidone (RIS) were formulated by spray-drying using Buchi Nano Spray Dryer B-90 (Flawil, Switzerland). Parameters such as inlet temperature, spray mesh diameter, sample flow rate, rate applied pressure optimized to produce having desired release profile low- high-molecular weight PLGA polymer. Smallest size nanoparticle of around 248 nm could be prepared a 4.0 μm diameter with...

The analgesic activity of fixed oil from the seeds Ocimum sanctum (Tulsi) was studied after intraperitoneal injection in mice and rats using tail flick, clip, immersion acetic acid-induced writhing methods; results were compared with morphine aspirin. It found that O. failed to raise pain threshold which indicated is not centrally mediated. Using method, showed significant inhibition a dose-dependent manner suggesting its possible mechanism related peripheral system.

The fixed oil of O. sanctum seeds was screened for antiarthritic activity using Freund's adjuvant arthritis, formaldehyde-induced arthritis and also turpentine oil-induced joint edema in rats. administered intraperitoneally 14 days the case adjuvant-induced 10 arthritis. mean changes diameter paw were noted at regular intervals. X-rays paws taken end study SGOT & SGPT levels estimated. showed significant anti-arthritic both models anti-edema against edema.