A5103015259- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Amino Acid Enzymes and Metabolism
- Adenosine and Purinergic Signaling
- Endoplasmic Reticulum Stress and Disease
- Neurotransmitter Receptor Influence on Behavior
- RNA regulation and disease
- Retinal Development and Disorders
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
Universidade Federal do Rio de Janeiro
2019-2022
Universidade Federal Fluminense
2014-2016
NYU Langone Health
2016
Treatments that promote protein synthesis in the brain may preserve cognition Alzheimer’s disease.
Abstract Introduction Depression is frequent among older adults and a risk factor for dementia. Identifying molecular links between depression dementia necessary to shed light on shared disease mechanisms. Reduced brain‐derived neurotrophic (BDNF) neuroinflammation are implicated in the pathophysiology of The exercise‐induced hormone, irisin, increases BDNF improves cognition animal models Alzheimer's disease. Lipoxin A4 lipid mediator with anti‐inflammatory activity. However, roles irisin...
Phosphorylation of GluA1, a subunit AMPA receptors (AMPARs), is critical for AMPAR synaptic trafficking and control transmission. cGMP-dependent protein kinase II (cGKII) mediates this phosphorylation, cGKII knockout (KO) affects GluA1 phosphorylation alters animal behavior. Notably, in the KO hippocampus increased as functional compensation gene deletion, while such absent prefrontal cortex. Thus, there are brain region-specific effects on trafficking, which could affect Here, we show that...
Abstract Neuronal protein synthesis is essential for long-term memory consolidation. Conversely, dysregulation of has been implicated in a number neurodegenerative disorders, including Alzheimer’s disease (AD). Several types cellular stress trigger the activation kinases that converge on phosphorylation eukaryotic translation initiation factor 2α (eIF2α-P). This leads to attenuation cap-dependent mRNA translation, component integrated response (ISR). We show AD brains exhibit increased...