A5033583735- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Proteoglycans and glycosaminoglycans research
- Cosmology and Gravitation Theories
- Regional Economic Development and Innovation
- Nicotinic Acetylcholine Receptors Study
- Blood properties and coagulation
- Educational Innovations and Challenges
- Space Science and Extraterrestrial Life
- Medical and Biological Sciences
- Rheumatoid Arthritis Research and Therapies
- Healthcare Systems and Public Health
- Coordination Chemistry and Organometallics
- Scientific Research and Philosophical Inquiry
- Historical Astronomy and Related Studies
- COVID-19 Clinical Research Studies
- Immunotoxicology and immune responses
- Carcinogens and Genotoxicity Assessment
- Liver physiology and pathology
- Synthesis and Biological Evaluation
- Adsorption, diffusion, and thermodynamic properties of materials
- Engineering Education and Technology
- Polymer Synthesis and Characterization
- Astrophysics and Cosmic Phenomena
- Heart Rate Variability and Autonomic Control
Institute of Cytology and Genetics
2019-2024
Institute of Clinical and Experimental Lymphology
2019-2024
Moscow State Pedagogical University
2019-2023
Siberian Branch of the Russian Academy of Sciences
2019-2023
Russian Academy of Sciences
2019-2021
Research Institute of Pharmacology and Regenerative Medicine named ED Goldberg
2020
The authors set the goal of conducting an ultrastructural analysis effect pegylated hyaluronidase on human hepatocyte cell culture from standpoint assessing toxicity and safety use.
Hyaluronidase is an enzyme that helps maintain optimal balance of hyaluronic acid in connective tissue and ensures full regeneration. Currently, hyaluronidase drugs are used various fields medicine. Meanwhile, there no oral preparations based on the pharmaceutical market due to its low bioavailability this method administration. One options increase electron-beam pegylation, which involves obtaining with a modified pharmacokinetic profile direction increasing enteral bioavailability, as well...
Enzyme preparations, including hyaluronidase, are widely used in medical practice. Most drugs with this active substance on the pharmaceutical market produced mainly from testicular raw material for which bovine testes. The technologies of enzyme preparation production quite well known and diverse. However, creation a different method will allow highly purified hyaluronate-endo-β-N-acetylhexosaminidase high specific enzymatic activity. Objective: develop technology obtain laboratory batch...
Fucoxanthin natural carotenoid from seaweeds exhibits antioxidant properties. The paper analyzes the possibility of using fucoxanthin, immobilized on aluminum-silicon carrier particles, to assess toxic effect naïve or matured immune cells, enterocytes, Mesenchymal stem and EA.Hy926 cell line. proliferation, nitric oxide production, myeloperoxidase activity, apoptosis thymocytes splenocytes mice in vitro were studied. Proliferative capacity, rate entreocytes, mesenchymal cells line...
Background: Previously, the results of phase II AURORA clinical study levilimab in subjects with active rheumatoid arthritis (RA) have been reported 1 . Here we report topline 24-weeks preliminary primary efficacy and safety analysis 3 double-blind, placebo-controlled randomized (SOLAR). Objectives: To confirm that combination methotrexate is superior to placebo achieving ACR20 at week 12 low disease activity (LDA) 24 (MTX) resistant RA. Methods: The ongoing 21 sites Russia Belarus. All...
Aim of the study was to evaluate effect lithium- and melatonin-containing sorbent based on aluminum oxide polydimethylsiloxane changes in number platelets during hemosorption modeling features hemostatic response dosed contact with blood an vitro experiment. Material methods . An analysis porous modified melatonin (MT, 0.15 %) lithium (0.5 (Al 2 O 3 @PDMS/MT-Li) carried out comparison without modifiers @PDMS) MT @PDMS/MT) a donor clotting parameters under conditions. Studies system included...
Introduction. Testicular hyaluronidase preparations are widely used in medical practice. Modification of native biologically active molecules by electron beam PEGylation allows to improve their pharmacokinetic properties, which determines a subsequent improvement pharmacodynamic effects. The development an original oral drug with pharmacologically core, is hyaluronidase, promising, but requires studying the safety use at preclinical stage. Aim. Ultrastructural evaluation hepatotoxic effects...
The widespread use of testicular hyaluronidase preparations determines the particular interest in development oral dosage form. drug under development, which is pegylated using electron beam immobilization technology (PEG-GIAL), requires an assessment its safety. Identification possible neurotoxic action, as well influence on cardiac function seems to be very relevant. Aim study was investigate effect PEG- GIAL behavioural reactions and electrical activity heart experimental animals....
The paper presents data on the synthesis and study of physical, chemical biological properties meso-, macroporous carbon-mineral carriers based mechanically strong aluminum oxide ( (γ-A1 <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> 0 xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ,) carbon. Carriers with a carbon content 7-10%, obtained at temperatures up to 700 °C, have hydrophilic-hydrophobic nature surface specific area 180...
The interaction of the demethylation product 1, 3, 5-trinitrobenzene—2, 4, 6-trinitrotoluene—with fluorinated alcohols followed by reduction perfluoroalkoxy-substituted m-dinitrobenzenes thus formed led to formation new diamines. reaction these diamines with aromatic tetracarboxylic acid dianhydrides polyimides combining solubility in organic solvents large ‘windows’ between glass transition and degradation temperatures.
It is known that the circadian rhythm of melatonin production depends on intensity illumination. Violation light regime leads to suppression synthesis and development desynchronosis, which increases risk developing a number pathologies. In this regard, it relevant search for opportunities restore disturbed rhythms and, especially, correct immune dysfunctions occur in these situations. The aim study was examine effect complex melatonin, aluminum oxide polymethylsiloxane lymphocytes spleen...
1 НИИ клинической и экспериментальной лимфологиифилиал ФИЦ Институт цитологии генетики СО РАН 630060, г.Новосибирск, ул.Тимакова, 2 фармакологии регенеративной медицины им.Е.Д.Гольдберга Томского национального исследовательского медицинского центра 634028, г
Rheumatoid arthritis (RA) is one of the most common rheumatic diseases. Dendritic cells (DCs) as main antigen-presenting play an important role in pathogenesis RA. There are two major DC populations: myeloid and plasmacytoid DCs (mDCs pDCs). B antibody-producing also The probability achieving low disease activity clinical laboratory remission has been proven to be maximal very early period patients who have not previously prescribed disease-modifying antirheumatic drugs (DMARDs). In this...
1 НИИ клинической и экспериментальной лимфологиифилиал ФИЦ «Институт цитологии генетики» СО РАН 630060, г
The presence of humans and animals under long-term continuous lighting leads to a suppression melatonin synthesis, that is, light-induced functional pinealectomy (LIFP), the development desynchronosis. To create LIFP, C57Bl/6 mice were kept 24-hour (24hL) for 14 days. in control group standard conditions. In next series experiments, with LIFP received daily intragastrically either (1 mg/kg body weight 200 μl distilled water) or water as placebo. comparison consisted intact placebo...
The development of safe drugs occupies a special place in the pharmaceutical industry. One main tasks its preclinical phase is to evaluate possible toxic effects developed drug on body and various systems, including immune system. aim our work was study immunotoxic properties pegylated hyaluronidase (PEG- HYAL). Material methods. Mice F1(CBA/C57Bl/6) were divided into subgroups which intragastric intraperitoneally administered with PEG-HYAL different dosages (50, 500, 1250, 2500 5000 U/kg)....
Hemosorbents used in medicine must be safe relation to blood cells, especially easily vulnerable platelets. The aim of this work is study the effect sorbents with single-walled carbon nanotubes Al <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> 0 xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> @ PDMS/SWNT comparison carbon-free sorbent @PDMS on hemostatic reactions. physicochemical properties was carried out according standard...
A retrospective analysis of the database register patients with immuno-inflammatory rheumatic diseases receiving treatment biologic disease-modifying anti-rheumatic drugs in Novosibirsk region was carried out, which included 318 patients, 94 whom had indications pneumonia during period from 01.04.2020 to 31.12.2020. There a statistically significant increase risk developing over age 60 years and rituximab, while therapy TNF-α inhibitors significantly reduced pneumonia. Keywords: COVID-19,...