A5010473304- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Neuroscience and Neural Engineering
- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Advanced MRI Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital heart defects research
- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Neurological disorders and treatments
- Cardiovascular Disease and Adiposity
Stanford University
2020-2023
Significance Electrophysiological mapping of chronic atrial fibrillation (AF) at high throughput and resolution is critical for understanding its underlying mechanism guiding definitive treatment such as cardiac ablation, but current electrophysiological tools are limited by either low spatial or electromechanical uncoupling the beating heart. We herein introduce a microfabricated high-density, fully elastic electrode (termed elastrode) array complex signal recording in vivo. demonstrated...
Newborn mammals, including piglets, exhibit natural heart regeneration after myocardial infarction (MI) on postnatal day 1 (P1), but this ability is lost by 7 (P7). The electrophysiologic properties of naturally regenerated myocardium have not been examined. We hypothesized that epicardial conduction preserved P1 MI in piglets. Yorkshire-Landrace piglets underwent left anterior descending coronary artery ligation at age ( n = 6) or P7 7), After weeks, cardiac magnetic resonance imaging was...
Objective Analyze changes in frequency activity and structural organization that occur over time with persistent atrial fibrillation (AF) Background Little is known about the characteristics of epicardium during transition from paroxysmal to AF. Accurate identification areas high dominant (DF) often hampered by limited spatial resolution. Improvements electrode arrays provide spatiotemporal resolution, allowing for characterization this transition. Methods AF was induced adult Yorkshire...
Abstract Cardiac electrophysiology mapping and ablation are widely used to treat heart rhythm disorders such as atrial fibrillation (AF) ventricular tachycardia (VT). Here, we describe an approach for rapid production of three dimensional (3D)‐printed devices derived from magnetic resonance imaging. The equipped with flexible electronic arrays that shaped match the epicardial contours atria ventricle allow electrical procedures. We validate these provide high‐resolution signals in vivo using...
Introduction: Newborn piglets reportedly exhibit natural heart regeneration after myocardial infarction (MI). However, the electrophysiologic properties of this regenerated muscle have not been examined. We hypothesized that epicardial electrical conduction is preserved MI in newborn piglets. Methods: Yorkshire-Landrace underwent left anterior descending coronary artery ligation on postnatal day 1 (P1, n=4) or 7 (P7, n=7), infarcting anteroseptal ventricle through which Purkinje system...
Abstract Objective Analyze changes in frequency activity and structural organization that occur over time with persistent atrial fibrillation (AF) Background Little is known about the characteristics of epicardium during transition from paroxysmal to AF. Accurate identification areas high dominant (DF) often hampered by limited spatial resolution. Improvements electrode arrays provide spatiotemporal resolution, allowing for characterization this transition. Methods AF was induced adult...