The curry powder spices turmeric (Curcuma longa L.), which contains curcumin (diferuloylmethane), an orange-yellow chemical. Polyphenols are the most commonly used sources of curcumin. It combats oxidative stress and inflammation in diseases, such as hyperlipidemia, metabolic syndrome, arthritis, depression. Most these benefits due to their anti-inflammatory antioxidant properties. Curcumin consumption leads decreased bioavailability, resulting limited absorption, quick metabolism,...

Abstract Neurodegenerative diseases are a group of with several neuropathological symptoms. Degenerative nerve can be serious or life‐threatening. Because the rise in older population recent years, these age‐dependent becoming more and common. The WHO reports that within few neurodegenerative will overtake cancer to become second leading cause fatalities cardiovascular being first. All have common ground they all associated some sort gene mutation subsequent protein dysfunction. This review...

The NEK7 protein is required for spindle formation, cell division, and the activation of NLRP3 inflammasome receptor. aberrant expression has been implicated to growth metastasis severe inflammatory conditions like rheumatoid arthritis, liver cirrhosis, gout. An emergent target development anti-cancer drugs NEK7. In this context, PubChem database was used retrieve 675 compound library FDA-approved kinase inhibitors, which were then thoroughly examined via in-silico experiments. Computational...

In the present study, we aimed to delineate neuroprotective potential of thymol (THY) against neurotoxicity and cognitive deterioration induced by thioacetamide (TAA) in an experimental model hepatic encephalopathy (HE). Rats received TAA (100 mg kg-1, intraperitoneally injected, three times per week) for two weeks. THY (30 60 kg-1), Vit E k-1) were administered daily oral gavage 30 days after HE induction. Supplementation with significantly improved liver function, reduced serum ammonia...

This study aimed to evaluate the antihypertensive efficacy of a new combination therapy Hibiscus sabdariffa and Olea europaea extracts (2 : 1; Roselle-Olive), using N(G)-nitro-L-arginine-methyl ester- (L-NAME-) induced hypertensive model. Rats received L-NAME (50 mg/kg/day, orally) for 4 weeks. Concurrent treatment with Roselle-Olive (500, 250, 125 mg/kg/day weeks) resulted in dose-dependent decrease both systolic diastolic blood pressure, reversed L-NAME-induced suppression serum nitric...

Diabetes mellitus (DM) has emerged as a public healthcare problem. Sustained hyperglycemia been linked with many complications including impaired male fertility Olive tree (Olea europaea L.) leaves have extensively used in traditional remedies worldwide to control blood glucose level DM. In this study, the beneficial role of olive extract (OLE) was investigated combat diabetes-induced adverse effect on testicular tissues. Thirty Wistar rats were divided into 5 equal groups: normal group,...

The present study investigated the gastroprotective activity of benzyl isothiocyanates (BITC) on indomethacin (IND)-induced gastric injury in a rat model and explicated possible involved biochemical, cellular, molecular mechanisms. with ulcers was established by single oral dose IND (30 mg per kg b.wt). BITC (0.75 1.5 kg-1) esomeprazole (20 b.wt) were orally administered for 3 weeks to rats before induction injury. Compared group, could diminish both macroscopic microscopic pathological...

Penconazole (PEN) is a widely used systemic fungicide to treat various fungal diseases in plants but it leaves residues crops and food products causing serious environmental health problems. N-acetylcysteine (NAC) precursor of the antioxidant glutathione body exerts prominent anti-inflammatory effects. The present study aimed explore mechanistic way NAC ameliorate PEN neurotoxicity male rats. Twenty-eight rats were randomly divided into four groups (n = 7) given treated material via oral...

The objective of the current study is to investigate effect rice bran oil (RBO) on hepatic fibrosis as a characteristic response persistent liver injuries. Rats were randomly allocated into five groups: negative control group, thioacetamide (TAA) group (thioacetamide 100 mg/kg thrice weekly for two successive weeks, ip), RBO 0.2 and 0.4 groups (RBO 0.2mL mL/rat/day, po ) standard (silymarin mg/kg/day, weeks after TAA injection. Blood tissue samples collected biochemical, molecular,...

Ulcerative colitis (UC) is the most common type of inflammatory bowel disease, characterized by oxidative stress and elevated pro-inflammatory cytokines. Miconazole an azole antifungal that stimulates expression antioxidant enzymes via Nrf2 activation, which consequently inhibits ROS formation NF-κB activation. Hence, present study aimed to investigate protective effect miconazole, sulfasalazine (as a reference drug) their combination on acetic acid (AA)-induced UC in rat model was induced...

Ischemia-reperfusion (IR) injury is a major cause of multiple organ failure. The purpose this study was to look into the role Tephrosia purpurea (TEP) and its active constituent pseudosemiglabrin (PS) in alleviating severe acute pancreatitis associated lung injury. We established rat pancreatic IR model, rats were treated with TEP (200 mg/kg 400 mg/kg) PS (20 40 mg/kg), addition control sham groups. results showed that respiratory parameters, including inspiratory time (Ti), expiratory (Te),...

The overexpression of urease is the root cause peptic ulcers and gastritis. Therefore, introducing new inhibitors against a possible therapeutic approach to overcoming pathogenesis; for instance, limiting risk development urinary calculi. Moreover, glycation leading several complications. Thus, in this study, we synthesized novel terephthalic dihydrazide analogues evaluated their biological importance. These were characterized using advanced spectroscopic techniques, such as 1H NMR, 13C 19F...

This study explores the synthesis and application of terpyridine-based metal complexes (C1-C6) for degradation diclofenac potassium (DCF), a widely used pharmaceutical pollutant. Terpyridine (TPY) ligands their were synthesized characterized using FTIR, UV-Vis, 1H NMR, 13C NMR spectroscopy, mass spectrometry. The novelty this lies in fact that, first time, such structures investigated/explored as potential photocatalysts DCF. demonstrates that target complex compounds exhibit remarkable...

The current investigation aimed to evaluate the antifibrogenic potential of Ocimum basilicum essential oil (OBE) and further explore some its underlying mechanisms. Three groups rats were used: group I (control), II (CCl4 model) III (OBE-treated) received CCl4 OBE 2 weeks after start administration. Oxidative damage was assessed by measurement MDA, NO, SOD, CAT, GSH total antioxidant capacity (TAC). Liver fibrosis histopathologically Masson's trichrome staining α-smooth muscle actin (α-SMA)...

The safety of Deltamethrin (DM) has been raised as a point concern. current investigation was envisaged to explore the responsiveness oxidative stress parameters, DNA fragmentation and expression levels TP53, cycloxygenase 2 (COX2) cytochrome p4502E1 (CYP2E1) toxicological endpoint in rats treated with DM. well attention provided neuroprotective effect vitamin E (VE).Four different groups were used this study, group I served control, II received DM (0.6 mg/kg BW), III both plus VE finally IV...

The potential toxicity of copper nanoparticles (CNPs) to the human health and environment remains a critical issue. In present study, we investigated protective influence an aqueous extract green tea leaves (GTE) against CNPs-induced (20-30 nm) hepatotoxicity. Four different groups rats were used: group I was control, II received CNPs (40 mg/kg BW), III plus GTE, IV GTE alone. We highlighted hepatoprotective effect through monitoring alteration liver enzyme activity, antioxidant defense...

Neuroprotective impact of transforming growth factor β1 (TGF-β1) is increasingly recognized in different brain injuries. Propolis exhibits a broad spectrum biological and pharmacological properties including neuroprotective action. The objective the investigation was to explore involvement TGF-β1 signaling mechanism propolis I/R rats. In this study, focal cerebral ischemia model built by middle artery occlusion (MCAO) for 2 h followed reperfusion. carried out on 48 rats that were arranged...