The renin-angiotensin system is a far more complex enzymatic cascade than realized previously. Mounting evidence suggests sex-specific differences in the regulation of and arterial pressure. We examined hemodynamic responses, angiotensin II receptor subtypes, angiotensin-converting enzyme 2 gene expression levels after graded doses males females. Mean pressure was measured via telemetry male female rats response to 2-week infusion vehicle, low-dose (50 ng/kg per minute SC) or high-dose (400...

Autistic adults experience a higher rate of physical and mental health conditions lower rates employment post-secondary education participation than their non-autistic counterparts, which may affect negatively quality life. Limited information exists on predictors life for autistic individuals, or how compares to individuals. Our aims were (a) examine compare indicators (e.g. sleep quality) anxiety) among sample 244 165 individuals aged 15–80 years (b) factors contributing 2 later the ( n =...

Autistic adults are willing and able employees but face a number of barriers to gaining maintaining meaningful employment, one which is lack exposure work experience workplace training opportunities. A case study an autism specific employment program presented, provided opportunity for autistic candidates learn role-related tasks at the site over extended assessment period, comprehensive transition support successful applicants. To date, limited data exists evaluating autism-specific hiring...

When applying for a job, autistic job candidates are likely to face number of challenges. Job interviews one these challenges - they require communicating and relationship-building with unfamiliar people involve expectations about behaviour (that may vary between companies not made clear candidates). Given communicate differently non-autistic people, be disadvantaged in the interview process. Autistic feel comfortable or safe sharing organisations their identity pressure hide any...

Background Limited research exists on the intricate relationship between dyslexia diagnoses and impact of associated labels adults. Dyslexia, affecting one in 10 adults, forming largest neurodivergent groups, involves a diagnostic label that communicates difficulties but can also perpetuate stigma. This multifaceted condition includes biological, psychological, social factors, with diverse terms used globally shaping societal perceptions. Methods qualitative study, part broader Australian...

Purpose – The purpose of this paper is to explore the impact three components psychological contract (i.e. obligations, fulfillment and breach) individual characteristic negative affectivity (NA) onto key outcomes, namely, job satisfaction, organizational identification distress. Design/methodology/approach Questionnaires were completed by 222 Australian nurses midwives from a medium-sized metropolitan hospital. response rate for study was 39 percent. Findings Structural equation modeling...

Autistic individuals face low rates of engagement in the labor force. There is evidence that job interviews pose a significant barrier to autistic people entering workforce. In this experimental study, we investigated impact diagnostic disclosure on decisions concerning candidate suitability during interviews.Participants (n = 357; 59% female) from general population rated 10 second "thin slices" simulated one male and non-autistic candidate. between-subjects design, autism was manipulated...

Although there are no known studies investigating autistic working mothers, research has demonstrated that managing employment and motherhood in non-autistic populations specific challenges, as does populations. This autistic-led study aimed at the experience of mothers to identify benefits, support needs.

Aims To assess the antecedents of workplace aggression (bullying and violence) among nurses administration staff. Background As a result power structures within healthcare industry, staff may be more vulnerable to aggression. Environmental individual characteristics have been linked occurrence such other groups. However, most research focuses on bullying, rarely extending these ideas violence or specifically. Methods Surveys were distributed employed by an Australian organisation. Aggression...

Many studies report sexual dimorphism in the fetal programming of adult disease. We hypothesized that there would be differences age-related decline renal function between male and female intrauterine growth-restricted rats. Early-life growth restriction was induced rat offspring by administering a low-protein diet (LPD; 8.7% casein) to dams during pregnancy lactation. Control were fed normal-protein (NPD; 20% casein). Mean arterial pressure (MAP) structure assessed 32- 100-wk-old offspring....

An autism diagnosis can have a big impact on women and make it possible to access support. This study explored women's experiences of being diagnosed with as an adult in Australia, try understand what was helpful (facilitators) unhelpful (barriers) for them during this process. We interviewed 10 autistic who had been the last 5 years. Framework analysis used data. wanted barriers facilitators relating individual participants, professionals they saw system went through their diagnostic...

SUMMARY 1. Medullary blood flow (MBF) is important in the long‐term control of arterial pressure. However, it unclear which vascular elements regulate MBF. 2. Exogenous endothelin (ET)‐1 decreases cortical more than medullary flow. We hypothesized that ET‐1 would therefore constrict afferent (AA) and efferent arterioles (EA) juxtamedullary glomeruli less those glomeruli. 3. Mean pressure, renal (CBF) flow, via laser‐Doppler flowmetry, were measured before after intrarenal (2 ng/kg per min; n...

Matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry (MALDI-TOF MS), is a sensitive analytical method capable of resolving DNA fragments varying in by single nucleotide. MALDI-TOF MS applicable to blood group genotyping, as the majority antigens are encoded nucleotide polymorphisms. Blood genotyping can be performed using panel (Hemo ID Group Genotyping Panel, Agena Bioscience Inc., San Diego, CA) that set assays predict phenotype for 101 from 16 systems. These...

Preexisting chronic hypertension complicates up to 5% of pregnancies and is associated with an increased risk low-birth-weight babies. Studies suggest that adverse intrauterine environment leading low birth weight linked cardiovascular disease, including hypertension, in the adult. In this study, blood pressure offspring from mothers were followed into adulthood. Two-kidney, 1-wrapped was induced 7 female rabbits; 5 other rabbits underwent sham surgery. Four weeks later, mated, at which time...

Previously, we demonstrated that adult blood pressure was increased in offspring of rabbit mothers with chronic secondary renal hypertension. Our study identified sex-specific differences the programming hypertension, female, not male, offspring, having at 30 wk age. The aim this to characterize maternal hypertension during pregnancy determine potential stimuli. Further, examined impact on birth weight, nephron number, and noradrenaline content (as an index innervation density). Three groups...

Workplace bullying is an occupational hazard in the healthcare industry. Allied health professionals form important, yet underresearched, part of this The aim study was to investigate antecedents and consequences within allied context. Data were collected from 166 working a large Australian organisation (response rate = 76%). Logistic regression analyses covariance conducted. Almost quarter (24%) respondents reported experiences workplace bullying. In testing bullying, low levels supervisor...

Industry-led employment programmes have emerged to transition autistic people into and meet industry labour needs. However, theoretical research is limited in this area, often failing appreciate the influence of broader ecosystem. In study, we interviewed 33 employees ( n = 29 males, M age 29.00 years) from two industry-led regarding their experience programme’s supports, relationships impact. We used qualitative content analysis identify five themes: (1) working involves multiple job tasks...

Previously, we have shown that adult offspring from hypertensive rabbits develop hypertension.We aimed to determine the effects of mild (+15 mmHg) and moderate (+25 increases in maternal blood pressure plasma renin activity on placental differentiation expression components renin-angiotensin system 11[beta]-hydroxysteroid dehydrogenase type 2 mRNA rabbits. Placentas were collected normotensive (sham), (2-kidney-1-cellophane wrapped; 2K-1W) (2-kidney-2-cellophane 2K-2W) groups at gestational...