A5076882595- Transcranial Magnetic Stimulation Studies
- Vestibular and auditory disorders
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Motor Control and Adaptation
- Neural and Behavioral Psychology Studies
- Nicotinic Acetylcholine Receptors Study
- Infant Development and Preterm Care
- Functional Brain Connectivity Studies
- Hemispheric Asymmetry in Neuroscience
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Genetic Neurodegenerative Diseases
- Heart Rate Variability and Autonomic Control
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Stress Responses and Cortisol
- EEG and Brain-Computer Interfaces
- Intraoperative Neuromonitoring and Anesthetic Effects
- Pain Management and Treatment
- Sleep and Wakefulness Research
- Trigeminal Neuralgia and Treatments
- Ophthalmology and Eye Disorders
- Conducting polymers and applications
University of Duisburg-Essen
2016-2025
Essen University Hospital
2016-2025
Erwin L. Hahn Institute for Magnetic Resonance Imaging
2024-2025
University of Göttingen
2012-2019
TU Dortmund University
2017-2018
Leibniz Research Centre for Working Environment and Human Factors
2017-2018
BG University Hospital Bergmannsheil Bochum
2017
Universitätsmedizin Göttingen
2017
Transcranial direct current stimulation (tDCS) of the human motor cortex at an intensity 1 mA with electrode size 35 cm(2) has been shown to induce shifts cortical excitability during and after stimulation. These are polarity-specific cathodal tDCS resulting in a decrease anodal increase excitability. In clinical cognitive studies, stronger intensities used frequently, but their physiological effects on have not yet explored. Therefore, here we aimed explore 2 We applied or for 20 min left...
Applications of transcranial direct current stimulation to modulate human neuroplasticity have increased in research and clinical settings. However, the need for longer-lasting effects, combined with marked inter-individual variability, necessitates a deeper understanding relationship between parameters physiological effects. We systematically investigated full DC intensity range (0.5-2.0 mA) both anodal cathodal tDCS sham-controlled repeated measures design, monitoring changes...
Abstract Transcranial direct current stimulation (tDCS) induces polarity‐ and dose‐dependent neuroplastic aftereffects on cortical excitability activity, as demonstrated by transcranial magnetic (TMS) functional imaging (fMRI) studies. However, lacking systematic comparative studies between stimulation‐induced changes in obtained from TMS, neurovascular activity fMRI, prevent the extrapolation of respective physiological mechanistic bases. We investigated intensity‐dependent effects tDCS...
Transcranial direct current stimulation (tDCS) of the cerebellum is increasing interest as a non-invasive technique to modulate motor performance and learning in health disease. Previous studies have shown that cerebellar tDCS facilitates reach adaptation associative healthy subjects. In present study it was tested whether improves complex whole body skill. Because this task involves posture balance likely including new sequence cognitive strategies, applied over midline structures...
The cerebellum is involved in the acquisition and consolidation of learned fear responses. Knowledge about its contribution to extinction learning, however, sparse. Extinction processes likely involve erasure memories, but there ample evidence that at least part original memory remains. We asked question whether persists within following training. renewal effect, reoccurrence extinguished during recall a context different from context, constitutes one phenomena indicating responses not fully...
Chronic administration of the selective noradrenaline reuptake inhibitor (NRI) reboxetine (RBX) increased and prolonged long-term potentiation-like plasticity induced by anodal transcranial direct current stimulation (tDCS) for over 24 h. RBX converted cathodal tDCS-induced depression-like into facilitation 120 min. noradrenergic activity enhancement on human brain might partially explain delayed therapeutic impact NRIs in depression other neuropsychiatric diseases.
Abstract The posterior parietal cortex is part of the cortical network involved in motor learning and structurally functionally connected with primary (M1). Neuroplastic alterations neuronal connectivity might be an important basis for processes. These have however not been explored parieto‐motor connections humans by transcranial direct current stimulation ( tDCS ). Exploring effects on relevant, because has shown to improve learning. We aimed explore plastic healthy humans. measured...
Abstract Background A brief bedside test has recently been introduced by Hoche et al. (Brain, 2018) to screen for the Cerebellar Cognitive Affective Syndrome (CCAS) in patients with cerebellar disease. Objective This multicenter study tested ability of CCAS-Scale diagnose CCAS individual common forms hereditary ataxia. Methods German version was applied 30 SCA3, 14 SCA6 and 20 FRDA patients, 64 healthy participants matched age, sex, level education. Based on original cut-off values, number...
Functional brain imaging studies in humans suggest involvement of the cerebellum fear conditioning but do not allow conclusions about functional significance. The main aim present study was to examine whether patients with cerebellar degeneration show impaired and this is accompanied by alterations cortical activations. To end, a 2 d differential conducted 20 21 control subjects using 7 tesla (7 T) MRI system. Fear acquisition extinction training were performed on day 1, followed recall 2....
Fear extinction is the foundation of exposure therapy for anxiety and phobias. However, stability memory diminishes over time, coinciding with fear recovery. To augment long-term retention, temporal distribution learning sessions critical. This study investigated effects massed spaced training (with short long intervals) on retention compared to a classic protocol. 120 healthy participants were recruited randomly divided training, 20-minutes or 3-hours intervals, control group. The group...
Fear extinction is a major component of exposure therapy for anxiety disorders. There initial evidence that the cerebellum contributes to fear learning, i.e., ability learn certain stimuli are no longer associated with an aversive outcome. So far, however, knowledge cerebellum's role in scarce. In present study, 6 Hz cerebellar transcranial alternating current stimulation (ctACS) was used modulate function during learning young and healthy human participants MRI study. A two-day differential...
The key elements for fear extinction learning are unexpected omissions of expected aversive events, which considered to be rewarding. Given its reception reward information, we tested the hypothesis that cerebellum contributes prediction error processing driving via connections with ventral tegmental area (VTA). Forty-three young and healthy participants performed a three-day conditioning paradigm in 7T MR scanner. VTA were active during unconditioned stimuli, particularly initial trials....
The key elements for fear extinction learning are unexpected omissions of expected aversive events, which considered to be rewarding. Given its reception reward information, we tested the hypothesis that cerebellum contributes prediction error processing driving via connections with ventral tegmental area (VTA). Forty-three young and healthy participants performed a three-day conditioning paradigm in 7T MR scanner. VTA were active during unconditioned stimuli, particularly initial trials....
Abstract Very preterm infants are at higher risk of long‐term neurodevelopmental and psychiatric impairments, including anxiety. Prematurity is also linked to altered programming the hypothalamus–pituitary–adrenal (HPA) axis, associated with stress‐related diseases. The cortisol awakening response (CAR), marked by a rapid increase after waking, biomarker HPA reactivity disorders. This study aimed evaluate for first time CAR in adults born very explore its association anxiety stress....
ABSTRACT Introduction Cerebellar brain inhibition (CBI) is a way to quantify the cerebellar influence on motor cortex in humans. Studies suggest that orientation of transcranial magnetic stimulation (TMS) coil influences which networks are activated. This study investigated direct current (ctDCS) CBI as function (anterior–posterior [AP] vs. posterior–anterior [PA]). An interstimulus interval (ISI) 7 ms (CBI‐AP‐7) was used for AP and 5 (CBI‐PA‐5) PA orientation. Methods Young healthy...