A5040609002- Genetic Neurodegenerative Diseases
- Vestibular and auditory disorders
- Mitochondrial Function and Pathology
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Ophthalmology and Eye Disorders
- Hemispheric Asymmetry in Neuroscience
- Advanced Neuroimaging Techniques and Applications
- DNA Repair Mechanisms
- Alzheimer's disease research and treatments
- Motor Control and Adaptation
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Substance Abuse Treatment and Outcomes
- COVID-19 Clinical Research Studies
- Lysosomal Storage Disorders Research
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Facial Nerve Paralysis Treatment and Research
- Psychosomatic Disorders and Their Treatments
- Poisoning and overdose treatments
- Nuclear Receptors and Signaling
- Botulinum Toxin and Related Neurological Disorders
- Metabolism and Genetic Disorders
- Pain Management and Opioid Use
University of Duisburg-Essen
2015-2025
Essen University Hospital
2012-2025
University of Applied Sciences Upper Austria
2024
MED-EL (Austria)
2024
Klinik und Poliklinik für Neurologie
2022
Alterations in the expression of Reelin (RELN) have been implicated pathology Alzheimer's disease (AD). However, whether these changes are cause or consequence AD remains to be resolved. To better understand role RELN pathway t
Transcranial direct current stimulation (tDCS) of the cerebellum is increasing interest as a non-invasive technique to modulate motor performance and learning in health disease. Previous studies have shown that cerebellar tDCS facilitates reach adaptation associative healthy subjects. In present study it was tested whether improves complex whole body skill. Because this task involves posture balance likely including new sequence cognitive strategies, applied over midline structures...
Background: A growing number of reports suggest that infection with SARS-CoV-2 often leads to neurological involvement; however, data on the incidence and severity are limited mainly case retrospective studies. Methods: This prospective, cross-sectional study 102 PCR positive patients investigated frequency, type, risk factors as well underlying pathophysiological mechanisms involvement (NIV) in COVID-19 patients. Results: Across cohort, 59.8% had NIV. Unspecific NIV was suffered by 24.5%,...
Spinocerebellar ataxia type 3 is a rare neurodegenerative disease caused by CAG repeat expansion in the ataxin-3 gene. Although no curative therapy yet available, preclinical gene-silencing approaches to reduce polyglutamine (polyQ) toxicity demonstrate promising results. In view of upcoming clinical trials, quantitative and easily accessible molecular markers are critical importance as pharmacodynamic particularly target engagement markers.We aimed at developing an ultrasensitive...
<h3>Importance</h3> Cerebellar ataxia is a neurodegenerative disease impairing motor function characterized by of stance, gait, speech, and fine disturbances. <h3>Objective</h3> To investigate the efficacy, safety, tolerability modified essential amino acid acetyl-DL-leucine in treating patients who have cerebellar ataxia. <h3>Design, Setting, Participants</h3> The Acetyl-DL-leucine on Ataxia (ALCAT) trial was an investigator-initiated, multicenter, double-blind, randomized,...
Functional brain imaging studies in humans suggest involvement of the cerebellum fear conditioning but do not allow conclusions about functional significance. The main aim present study was to examine whether patients with cerebellar degeneration show impaired and this is accompanied by alterations cortical activations. To end, a 2 d differential conducted 20 21 control subjects using 7 tesla (7 T) MRI system. Fear acquisition extinction training were performed on day 1, followed recall 2....
Cerebellar atrophy is the neuropathological hallmark of most ataxias. Hence, quantifying volume cerebellar grey and white matter great interest. In this study, we aim to identify differences in cerebellum between spinocerebellar ataxia type 1 (SCA1), SCA3 SCA6 as well multiple system (MSA-C). Our cross-sectional data set comprised mutation carriers SCA1 (N=12), (N=62), (N=14), MSA-C patients (N=16). volumes were obtained from T1-weighted magnetic resonance images. To compare different...
ABSTRACT Introduction Cerebellar brain inhibition (CBI) is a way to quantify the cerebellar influence on motor cortex in humans. Studies suggest that orientation of transcranial magnetic stimulation (TMS) coil influences which networks are activated. This study investigated direct current (ctDCS) CBI as function (anterior–posterior [AP] vs. posterior–anterior [PA]). An interstimulus interval (ISI) 7 ms (CBI‐AP‐7) was used for AP and 5 (CBI‐PA‐5) PA orientation. Methods Young healthy...
Psychological parameters related to alcohol dependence (AD) affect patients' behavioral and cognitive control, decision making, impulsivity inhibitory control. People with AD often have a chronic course relapse dependent substance use even after extensive treatment. This study investigated whether the psychological of patients predict (a) premature termination treatment, and/or (b) into consumption from admission until 6 weeks discharge an inpatient rehabilitation Participants:...
Background/Objectives: According to a diathesis–stress model for the development of mental illness, it is assumed that, in addition pre-existing individual vulnerability, occurrence acute strains an etiological factor. The SARS-CoV-2 pandemic was collective massive stressor, which could predispose first manifestation disorder or exacerbation disorder. aim this study investigate effects on cohort patients admitted hospital during year pandemic. Methods: Patients inpatient treatment university...
Transcriptional dysregulation has been described in spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD), an autosomal dominant caused by a polyglutamine expansion the ataxin-3 protein. As is ubiquitously expressed, transcriptional alterations blood may reflect early changes that start before clinical onset and might serve as peripheral biomarkers research settings. Our goal was to describe enriched pathways report dysregulated genes, which can track onset, severity or progression...
Understanding cerebellar alterations due to healthy aging provides a reference point against which pathological findings in late-onset disease, for example spinocerebellar ataxia type 6 (SCA6), can be contrasted. In the present study, we investigated impact of on nuclei and cortex 109 controls (age range: 16 - 78 years) using 3 Tesla magnetic resonance imaging (MRI). Findings were compared with 25 SCA6 patients 38 years). A subset (included: 14) 50 45) received an additional MRI scan at 7...
Abstract Background Cerebellar transcranial direct current stimulation (tDCS) is widely considered as a promising non-invasive tool to foster motor performance and learning in health disease. The results of previous studies, however, are inconsistent. Our group failed provide evidence for an effect cerebellar tDCS on complex whole body dynamic balance task young healthy participants. Ceiling effects the study population one possible explanation negative findings. Methods In present study, we...
Abstract Cerebellar degeneration progressively impairs motor function. Recent research showed that cerebellar patients can improve performance with practice, but the optimal feedback type (visual, proprioceptive, verbal) for such learning and underlying neuroplastic changes are unknown. Here, ( N = 40) age‐ sex‐matched healthy controls practiced single‐joint, goal‐directed forearm movements 5 days. improved during visuomotor a training focusing on either proprioceptive feedback, or explicit...
NEW & NOTEWORTHY: Neurodegeneration of the cerebellum progresses over years and primarily affects cerebellar cortex. It leads to a progressive loss control coordination movement. We here show that neurodegenerative process not only cells in cortex but also induces neurostructural changes form increased gray matter efferent targets cortex, namely, output nuclei, SMA, premotor
Several diffusion tensor imaging studies reveal that white matter (WM) lesions are common in children suffering from benign cerebellar tumours who treated with surgery only. The clinical implications of WM alterations occur as a direct consequence disease have not been thoroughly studied. Here, we analysed structural and data patients chronic surgical after resection for tumours. We aimed to elucidate the impact focal cerebellum on integrity across entire brain, investigate whether deficits...
A 47-year-old Caucasian man of non-consanguineous parents presented with a slowly progressive gait disorder and falls. Disease manifestations were present since early childhood mild motor mental retardation. Slowly cerebellar ataxia, proximal muscle weakness atrophy, cognitive decline incomplete ophthalmoplaegia developed in late adolescence. At the time presentation, he was still able to walk unaided for short distances. MRI brain (figure 1A, B) revealed marked atrophy. The brainstem...
Patients' expectations toward any given treatment are highly important for the effectiveness of such treatment, as has been demonstrated several disorders. In particular, in major depressive disorder (MDD), one most frequent and serious mental disorders with severe consequences affected, augmentation available options could mean a ground-breaking success. Repetitive transcranial magnetic stimulation (rTMS), new, non-invasive, well-tolerated intervention proven effects MDD, appears...
Abstract Background : Cerebellar atrophy is the neuropathological hallmark of most ataxias. Hence, quantifying volume cerebellar grey and white matter great interest. In this study, we aim to identify differences in cerebellum between spinocerebellar ataxia type 1 (SCA1), SCA3 SCA6 as well multiple system (MSA-C). Methods Our cross-sectional data set comprised mutation carriers SCA1 (N=12), (N=62), (N=14), MSA-C patients (N=16). volumes were obtained from T1-weighted magnetic resonance...