A5077889277- Biosimilars and Bioanalytical Methods
- Pesticide Residue Analysis and Safety
- Migraine and Headache Studies
- Microfluidic and Capillary Electrophoresis Applications
- Antibiotics Pharmacokinetics and Efficacy
- Hormonal and reproductive studies
- Thyroid Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Analytical Methods in Pharmaceuticals
- Helicobacter pylori-related gastroenterology studies
- Protein purification and stability
- Gastroesophageal reflux and treatments
- Drug Solubulity and Delivery Systems
- Advanced Proteomics Techniques and Applications
- Hormonal Regulation and Hypertension
- Mass Spectrometry Techniques and Applications
- Bacterial Identification and Susceptibility Testing
- Pharmacogenetics and Drug Metabolism
Bristol-Myers Squibb (United States)
2012-2019
Bristol-Myers Squibb (Germany)
2013
Bioanalytical Systems (United States)
2012
Calcitonin gene-related peptide (CGRP) may play a causal role in migraine. Blocking the CGRP receptor be an effective approach to migraine relief while avoiding vasoconstrictive effects associated with triptans. BMS-927711 is potent, selective, antagonist. The
RATIONALE Esterase inhibitors are widely used to stabilize ester‐containing drugs in biological matrices for quantitative liquid chromatography/tandem mass spectrometry (LC/MS/MS) assays. These co‐existing could cause matrix effects on bioanalysis and jeopardize the assay performance. We therefore developed an LC/MS/MS methodology monitor fate of evaluate their effects, which is described this study. METHODS Human plasma containing 20 mM diisopropylfluorophosphate (DFP), paraoxon, eserine,...
A UHPLC-MS/MS assay was developed to quantify urinary dehydroepiandrosterone (DHEA), 7β-hydroxy-DHEA, cortisone and 6β-hydroxycortisone as potential biomarkers predict CYP3A activity.A sensitive at LLOQ of 0.500 ng/ml with good accuracy precision for the four analytes in human urine. This optimized by eliminating nonspecific loss urine, ensuring complete hydrolysis conjugates unconjugated forms use product ions [M+H-H2O]+ multiple reaction monitoring detection DHEA 7β-hydroxy-DHEA.This...