A5038485807- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Fullerene Chemistry and Applications
- HIV/AIDS drug development and treatment
- Computational Drug Discovery Methods
- Boron and Carbon Nanomaterials Research
- Cyclopropane Reaction Mechanisms
- Advanced Chemical Physics Studies
- Gastroesophageal reflux and treatments
- Hepatitis C virus research
- Organometallic Complex Synthesis and Catalysis
- Analytical Methods in Pharmaceuticals
- Asymmetric Synthesis and Catalysis
- Protein purification and stability
- Fluorine in Organic Chemistry
- Melanoma and MAPK Pathways
- Analytical Chemistry and Chromatography
- Pneumocystis jirovecii pneumonia detection and treatment
- Synthetic Organic Chemistry Methods
- Advanced NMR Techniques and Applications
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- HIV-related health complications and treatments
- HIV Research and Treatment
Bristol-Myers Squibb (United States)
2006-2024
Bristol-Myers Squibb (Germany)
2006-2014
Rice University
1994-1997
University of Duisburg-Essen
1995
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalysis of Isomers the Higher Fullerenes by 3He NMR SpectroscopyM. Saunders, H. A. Jimenez-Vazquez, R. J. Cross, W. E. Billups, C. Gesenberg, Gonzalez, Luo, Haddon, F. Diederich, and HerrmannCite this: Am. Chem. Soc. 1995, 117, 36, 9305–9308Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September...
The discovery of BMS-605339 (35), a tripeptidic inhibitor the NS3/4A enzyme, is described. This compound incorporates cyclopropylacylsulfonamide moiety that was designed to improve potency carboxylic acid prototypes through introduction favorable nonbonding interactions within S1′ site protease. identification 35 enabled optimization and balance critical properties including pharmacokinetics (PK). achieved modulation P2* subsite which identified isoquinoline ring system as key template for...
Weak base therapeutic agents can show reduced absorption or large pharmacokinetic variability when coadministered with pH-modifying agents, in achlorhydria disease states, due to dissolution rate and/or solubility at high gastric pH. This is often referred as pH-effect. The goal of this study was understand why some drugs exhibit a stronger pH-effect than others. To this, an API-sparing, two-stage, vitro microdissolution test developed generate drug dissolution, supersaturation, and...
In search for prodrugs to address the issue of pH-dependent solubility and exposure associated with 1 (BMS-582949), a previously disclosed phase II clinical p38α MAP kinase inhibitor, structurally novel prodrug, 2 (BMS-751324), featuring carbamoylmethylene linked promoiety containing hydroxyphenyl acetic acid (HPA) derived ester phosphate functionalities, was identified. Prodrug not only stable but also water-soluble under both acidic neutral conditions. It effectively bioconverted into...
The adduct (I) formed by the reaction of diradical obtained heating cyclopropa[b]naphthalene with 3He-labeled C60 has been characterized. corresponding 1h, 13C, and 3He NMR spectra are reported.
Abstract Carbonyl ylide‐like intermediates are involved in the 1,5‐electrocyclization of bicyclo[3.2.0]heptenes 3a–c . The activation barriers analyzed by time‐ and temperature‐dependence exo ⇌ endo isomerization specifically deuterated derivatives or racemization optically active turned out to be higher Δ ΔG ≠ ≥ 11 kcal/mol than those determined for corresponding bicyclo [3.1.0]hexenes 1a–c This result can considered as an evidence electrocyclic nature these ring openings due diminished...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”