A5101638482- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Genomics and Chromatin Dynamics
- Neonatal Health and Biochemistry
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- HIV/AIDS drug development and treatment
- Erythrocyte Function and Pathophysiology
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Enzyme Structure and Function
- Biochemical and Molecular Research
- Hemoglobin structure and function
- Metabolism and Genetic Disorders
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Acute Lymphoblastic Leukemia research
John Radcliffe Hospital
2018
Institute of Molecular Medicine
2018
University of Oxford
2013-2018
Centre for Human Genetics
2013
Boston University
2011
Innsbruck Medical University
2003
Cell fate is governed by combinatorial actions of transcriptional regulators assembling into multiprotein complexes. However, the molecular details how these complexes form are poorly understood. One such complex, which contains basic-helix-loop-helix heterodimer SCL:E47 and bridging proteins LMO2:LDB1, critically regulates hematopoiesis induces T cell leukemia. Here, we report crystal structure (SCL:E47)bHLH:LMO2:LDB1LID bound to DNA, providing a account network interactions this complex....
Human Npm2 is an ortholog of Xenopus nucleoplasmin (Np), a chaperone that binds histones. We have determined the crystal structure truncated Npm2-core at 1.9 Å resolution and show N-terminal domains Np form similar pentamers. This allowed us to model decamer which may be formed by hydrogen bonds between quasi-conserved residues in interface two Interestingly, pentamer lacks prototypical A1-acidic tract each its subunits. feature responsible for inability bind However, with large acidic...
According to the mathematical model, dependence of rate glycolysis on ATP concentration can be represented by bell‐shaped curve with descending part at close physiological values. The existence is a result strong inhibition phosphofructokinase and hexokinase glucose 6‐phosphate provides stabilisation intracellular ATP. Using arsenate as an uncoupler oxidation synthesis, in erythrocytes was measured. This (glycolysis characteristic) curve. normalized characteristics are same for all donors...
Lens epithelium-derived growth factor (LEDGF)/p75 is the dominant binding partner of HIV-1 integrase in human cells. The crystal structure HIV integrase-binding domain (IBD) LEDGF has been determined absence ligand. IBD was overexpressed Escherichia coli , purified and crystallized by sitting-drop vapour diffusion. X-ray diffraction data were collected at Diamond Light Source to a resolution 2.05 Å. crystals belonged space group P 2 1 with eight polypeptide chains asymmetric unit arranged as...