Reversal of multidrug resistance (MDR) by thirty resin glycosides from the morning glory family (Convolvulaceae) was evaluated in vinblastine-resistant human breast carcinoma cells (MCF-7/Vin). The effects these amphipathic compounds on cytotoxicity and P-glycoprotein (P-gp)-mediated MDR were estimated with sulforhodamine B colorimetric assay. Active noncytotoxic exerted a potentiation effect vinblastine susceptibility 1- to over 1906-fold at tested concentrations 5 25 μg/mL. Murucoidin V...

The allelopathic potential of Ipomoea tricolor (Convolvulaceae), used in Mexican traditional agriculture as a weed controller, has been demonstrated by measuring the inhibitory activity organic extracts on seedling growth Amaranthus leucocarpus and Echinochloa crus-galli. Bioactivity-directed fractionation active CHCl3 extract led to isolation principle, which turned out be mixture so-called "resin glycosides" convolvulaceous plants. structure tricolorin A, major phytogrowth inhibitor...

Twenty-two convolvulaceous oligosaccharides selected from the tricolorin (1−7), scammonin (8, 9), and orizabin (10−22) series were evaluated for activity against a panel of Staphylococcus aureus strains possessing or lacking specific efflux pumps. The minimum inhibitory concentrations (MIC values) most amphipatic compounds ranged 4 to 32 μg/mL XU-212 (possessing TetK multidrug pump) SA-1199B (overexpressing NorA pump), compared with 64 0.25 μg/mL, respectively, tetracycline. This was shown...

A reinvestigation of the CHCl3-soluble extract from flowers Mexican medicinal arborescent morning glory, Ipomoea murucoides, through preparative-scale recycling HPLC, yielded six new pentasaccharides, murucoidins VI−XI (1−6), as well known pescaprein III (7), stoloniferin I (8), and I−V (9−13). Their structures were characterized interpretation their NMR spectroscopic FABMS data. Compounds 1−6 found to be macrolactones three glycosidic acids identified simonic B, operculinic acid A, with...

Galphimia glauca is popularly employed in Mexico for the treatment of central nervous system disorders. Pharmacological and phytochemical studies have resulted identification anxiolytic sedative principle consisting a mixture nor-secofriedelanes, named galphimine series (1 - 9). These active constituents were found plants collected vicinity restricted region Central Mexico, where this species abundant. A metabolic profiling carried out by means 1H-NMR spectroscopy multivariate data analysis...

By bioactivity-directed fractionation, three new antimicrobial and cytotoxic 5,6-dihydro-alpha-pyrones, pectinolides A-C, have been isolated from Hyptis pectinata (Lamiaceae). The absolute stereochemistry of pectinolide A [1] was established as 6S-[(3S-acetyloxy)-1Z-heptenyl]-5S-(acetyloxy)-5 ,6-dihydro-2H-pyran-2-one, on the basis spectral, chiroptical, chemical evidence. structures B [2] C [3] were determined monodeacetylated forms 1 by comparison their spectral data correlation with...

Parotoid gland secretions of toad species are a vast reservoir bioactive molecules with wide range biological properties. Herein, for the first time, it is described isolation by preparative reversed-phase HPLC and structure elucidation NMR spectroscopy and/or mass spectrometry nine major bufadienolides from parotoid Cuban endemic Peltophryne fustiger: ψ-bufarenogin, gamabufotalin, bufarenogin, arenobufagin, 3-(N-suberoylargininyl) marinobufagin, bufotalinin, telocinobufagin, marinobufagin...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCytotoxic Constituents from Hyptis verticillataMiriam Novelo, José G. Cruz, Lourdes Hernández, Rogelio Pereda-Miranda, Heebyung Chai, Woongchon Mar, and John M. PezzutoCite this: J. Nat. Prod. 1993, 56, 10, 1728–1736Publication Date (Print):October 1, 1993Publication History Published online1 July 2004Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/np50100a011https://doi.org/10.1021/np50100a011research-articleACS...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTriterpenoids and Flavonoids from Hyptis albidaRogelio Pereda-Miranda Guillermo DelgadoCite this: J. Nat. Prod. 1990, 53, 1, 182–185Publication Date (Print):January 1990Publication History Published online1 July 2004Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/np50067a028https://doi.org/10.1021/np50067a028research-articleACS PublicationsRequest reuse permissionsArticle Views418Altmetric-Citations39LEARN ABOUT THESE...

The hexane-soluble extract from the aerial parts of herbal drug Ipomoea pes-caprae (beach morning-glory), through preparative-scale recycling HPLC, yielded six lipophilic glycosides, namely, five new pentasaccharides jalapinolic acid, pescaproside A (1) and pescapreins I−IV (2−5), as well known stoloniferin III (6). Saponification crude resin glycoside mixture simonic acid B (7) glycosidic component, whereas esterifying residues natural oligosaccharides comprised fatty acids:...

As part of the ICBG program Bioactive Agents from Dryland Biodiversity Latin America, present investigation was undertaken to explore possible antimycobacterial potential compounds derived selected Mexican medicinal plants. Bioassay-guided fractionation crude extracts Rumex hymenosepalus (Polygonaceae), Larrea divaricata (Zygophyllaceae), Phoradendron robinsonii (Loranthaceae) and Amphipteryngium adstringens (Julianiaceae) led isolation several compounds. Four stilbenoids, two flavan-3-ols...

Mexican Jalap roots, a prehispanic medicinal plant complex still considered to be useful laxative, can found as an ingredient in some over-the-counter products sold by herbalists contemporary Mexico. The drug is prepared from the dried roots of several morning glories, all which have been identified members genus Ipomoea. Analysis commercial samples was assessed generating HPLC and 13C NMR spectroscopic profiles glycosidic acids obtained through saponification resin glycoside contents. These...

Batatins I (1) and II (2), two ester-type dimers of acylated pentasaccharides, have been isolated by recycling HPLC from the hexane-soluble extract sweet potato (Ipomoea batatas var. batatas). The structures were elucidated a combination high-resolution NMR spectroscopy mass spectrometry. Complete analysis unambiguous assignments 1H 13C spectra 1 2 achieved 2D shift correlation measurements. glycosidic acid forming each branched pentasaccharide monomeric unit was confirmed as simonic B....