A5017302106- Pain Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Veterinary Pharmacology and Anesthesia
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Hormonal Regulation and Hypertension
- Neuropeptides and Animal Physiology
- Phosphodiesterase function and regulation
- Apelin-related biomedical research
- Olfactory and Sensory Function Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Regulation of Appetite and Obesity
- Pain Management and Placebo Effect
- Drug-Induced Hepatotoxicity and Protection
- Fatty Acid Research and Health
- Pharmacological Effects and Assays
- Eicosanoids and Hypertension Pharmacology
- Treatment of Major Depression
- Pharmacogenetics and Drug Metabolism
Louisiana State University Health Sciences Center New Orleans
2016-2024
Southeast Louisiana Veterans Health Care System
2020-2024
Louisiana State University
2023
Kansas Health Sciences Center
2020
Tulane University
2016
Reversible phosphorylation, a fundamental regulatory mechanism required for many biological processes including memory formation, is coordinated by the opposing actions of protein kinases and phosphatases. Type I phosphatase (PP1), in particular, has been shown to constrain learning formation. However, how PP1 might be regulated still not clear. Our previous work elucidated that inhibitor-2 (I-2) an endogenous regulator hippocampal cortical neurons (Hou et al., 2013). Contrary expectation,...
Alcohol use disorder (AUD) produces cognitive deficits, indicating a shift in prefrontal cortex (PFC) function. PFC glutamate neurotransmission is mostly mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type ionotropic receptors (AMPARs); however preclinical studies have focused on other receptor subtypes. Here we examined the impact of early withdrawal from chronic ethanol AMPAR function mouse medial (mPFC). Dependent male C57BL/6J mice were generated using intermittent...
Abstract In contrast to their analgesic properties, excessive use of either opioids or alcohol produces a paradoxical emergence heightened pain sensitivity noxious stimuli, termed hyperalgesia, which may promote increased drinking manage worsening symptoms. Hyperalgesia has traditionally been measured in rodents via reflex‐based assays, including the von Frey method. To better model motivational and affective dimensions state opioid/alcohol dependence withdrawal, this unit describes...
Although acetaminophen (ApAP) is one of the most commonly used medicines worldwide, hepatotoxicity a risk with overdose or in patients compromised liver function. ApAP common cause acute fulminant hepatic failure. Oxidation to N-acetyl-p-benzoquinone imine (NAPQI) mechanism for hepatotoxicity. 1 non-hepatotoxic, metabolically unstable lipophilic analog that not antipyretic. The newly synthesized 3 non-hepatotoxic stable, lipophilic, and retains analgesia antipyresis. Intraperitoneal po...
The dorsal hippocampus and striatum have dissociable roles in learning memory that are related to region-specific changes proteins necessary for neuronal plasticity formation. There is additional evidence the can interact during Phosphorylation of tyrosine receptor kinase B important formation hippocampus, but whether or not it has a role striatum-dependent learning, interactions between striatum, been examined. In present study, we tested hypothesis response training increases pTrkB...
The transition from recreational alcohol use to alcoholism is associated with an escalation of drinking as well cognitive deficits. This process may be mediated via specific brain regions both learning and reward. Dietary omega‐3 fatty acids incorporate into the cell membrane are important signaling mediators that potentially alter memory mechanisms and/or drinking. Male Wistar rats (approximately 300 g) were divided two groups fed a diet omega‐6:omega‐3 ratio 19.6:1 (fat source corn oil) or...
Alcohol use disorder (AUD) produces cognitive deficits in emotional processing, decision-making, inhibitory control, and working memory, indicating a shift prefrontal cortex (PFC) function. PFC excitatory neurotransmission is mostly mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type ionotropic glutamate receptors (AMPARs); however preclinical studies have focused on other receptor subtypes. Therefore, here we examined the impact of early withdrawal from chronic ethanol...
In contrast to their analgesic properties, excessive use of either alcohol or opioids produces a paradoxical emergence heightened pain sensitivity noxious stimuli, termed hyperalgesia, which may promote further drinking manage worsening symptoms. Hyperalgesia has traditionally been measured in rodents via reflex‐based assays, including the von Frey method. To better model cognitive/motivational dimension state alcohol/opioid dependence and withdrawal, we employed recently developed...