A5016994280- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Circular RNAs in diseases
- Inflammation biomarkers and pathways
- Extracellular vesicles in disease
- Aluminum toxicity and tolerance in plants and animals
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Drug-Induced Hepatotoxicity and Protection
- Retinal Development and Disorders
- Gut microbiota and health
- Cannabis and Cannabinoid Research
- Eicosanoids and Hypertension Pharmacology
- RNA regulation and disease
- interferon and immune responses
- Sphingolipid Metabolism and Signaling
- Advanced biosensing and bioanalysis techniques
- Redox biology and oxidative stress
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- X-ray Diffraction in Crystallography
- Tryptophan and brain disorders
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
Louisiana State University Health Sciences Center New Orleans
2015-2024
Louisiana State University
2012-2023
Louisiana Tech University
2011-2012
OPINION article Front. Cell. Neurosci., 17 September 2013Sec. Cellular Neuropathology Volume 7 - 2013 | https://doi.org/10.3389/fncel.2013.00153
OPINION article Front. Aging Neurosci., 16 June 2014Sec. Alzheimer's Disease and Related Dementias Volume 6 - 2014 | https://doi.org/10.3389/fnagi.2014.00127
The aggregation of Aβ42-peptides and the formation drusen in age-related macular degeneration (AMD) are due part to inability homeostatic phagocytic mechanisms clear self-aggregating from extracellular space. triggering receptor expressed myeloid/microglial cells-2 (TREM2), a trans-membrane-spanning, sensor-receptor immune-globulin/lectin-like gene superfamily is critical component Aβ42-peptide clearance. Here we report significant deficit TREM2 AMD retina cytokine- or oxidatively-stressed...
Murine transgenic models of Alzheimer's disease (Tg-AD) have been useful to analyze the contribution β-amyloid precursor protein (βAPP), Aβ42 peptide deposition, and proinflammatory mechanisms that characterize Alzheimer-type neuropathology. In this report, we studied levels βAPP, Aβ40 peptide, as well innate immune inflammatory response-regulator complement factor H in brain retina four different Tg-AD including Tg2576, PSAPP, 3xTg-AD, 5xFAD. Aged, symptomatic 5xFAD mice showed highest...
Genetic deficits and loss of function for the triggering receptor expressed in myeloid cells 2 (TREM2; encoded at chr6p21.1), a transmembrane spanning stimulatory immunoglobulin/lectin-like gene superfamily, have been associated with deficiencies phagocytosis innate immune system Alzheimer's disease. In this study, we provide evidence that TREM2 is downregulated samples sporadic Alzheimer hippocampal CA1 compared age-matched controls. A nuclear factor-кB (NF-кB)-sensitive miRNA-34a (encoded...
OPINION article Front. Aging Neurosci., 08 April 2014Sec. Alzheimer's Disease and Related Dementias Volume 6 - 2014 | https://doi.org/10.3389/fnagi.2014.00062
Alzheimer's disease is a progressive, neurodegenerative disorder that develops within the limbic system, spreading radially into anatomically linked brain association areas as progresses. Analysis of temporal-lobe neocortex-derived extracellular fluid and cerebrospinal from patients shows an abundant presence micro-RNA (miRNA), including proinflammatory miRNA-146a miRNA-155. Using novel highly sensitive LED-Northern dot-blot focusing technique, we detected secretion potentially pathogenic...
Docosahexaenoic acid (DHA, 22:6 n-3) is abundant in the retina and enzymatically converted into pro-homeostatic docosanoids. The DHA- or eicosapentaenoic (EPA)-derived 26 carbon fatty a substrate of elongase ELOVL4, which expressed photoreceptor cells generates very long chain (≥C28) polyunsaturated acids including n-3 (VLC-PUFAs,n-3). While ELOVL4 mutations are linked to vision loss neuronal dysfunctions, roles VLC-PUFAs remain unknown. Here we report novel class lipid mediators...
Down's syndrome, a congenital disorder associated with cognitive impairment and early-onset Alzheimer's disease, is progressive genetic pathology resulting from full or partial triplication of chromosome 21. syndrome brain typified by activated microglia, increases in inflammatory signaling, an aberrant immune system. In these studies, screening micro-RNA (miRNA) peripheral tissues indicated upregulation 21-encoded miRNA-155 decrease the abundance mRNA target complement factor H (CFH),...
We report the discovery of a novel family prohomeostatic and neuroprotective lipid mediators called elovanoids.
Abstract Temporal lobe epilepsy or limbic lacks effective therapies due to a void in understanding the cellular and molecular mechanisms that set motion aberrant neuronal network formations during course of epileptogenesis (LE). Here we show vivo rodent models LE phospholipid mediator platelet-activating factor (PAF) increases PAF receptor (PAF-r) ablation mitigates its progression. Synthetic PAF-r antagonists, when administered intraperitoneally LE, re-establish hippocampal dendritic spine...
Evolution of reactive oxygen species (ROS), generated during the patho-physiological stress nervous tissue, has been implicated in etiology several progressive human neurological disorders including Alzheimer’s disease (AD) and amylotrophic lateral sclerosis (ALS). In this brief communication we used mixed isomers 5-(and-6)-carboxy-2′,7′-dichlorofluorescein diacetate (carboxy-DCFDA; C25H14Cl2O9; MW 529.3), a novel fluorescent indicator, to assess ROS generation within neuronal-glial (HNG)...
OPINION article Front. Aging Neurosci., 17 June 2014Sec. Alzheimer's Disease and Related Dementias Volume 6 - 2014 | https://doi.org/10.3389/fnagi.2014.00116