A5077273045- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Metal complexes synthesis and properties
- Enzyme Structure and Function
- Microtubule and mitosis dynamics
- Galectins and Cancer Biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Cellular transport and secretion
- Advanced Biosensing Techniques and Applications
- Cancer-related Molecular Pathways
- Transgenic Plants and Applications
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
Roche Pharma AG (Germany)
2003-2023
Roche (United States)
2008
The importance and effect of Fc glycosylation monoclonal antibodies with regard to biological activity is widely discussed has been investigated in numerous studies. from current production systems subject batch-to-batch variability. If there are changes between different batches, these observed not only for one but multiple glycan species. Therefore, studying the distinct species such as galactosylated sialylated structures challenging due lack well-defined differences patterns samples...
There are few treatments that slow neurodegeneration in Alzheimer's disease (AD), and while therapeutic antibodies being investigated clinical trials for AD treatment, their access to the central nervous system is restricted by blood–brain barrier. This study investigates a bispecific modular fusion protein composed of gantenerumab, fully human monoclonal anti- amyloid-beta (Aβ) antibody under investigation with transferrin receptor 1-directed Brainshuttle™ module (trontinemab; RG6102, INN...
Aurora kinase inhibitors have attracted a great deal of interest as new class antimitotic agents. We report novel based on pentacyclic scaffold. A prototype inhibitor 32 (AKI-001) derived from two early lead structures improves upon the best properties each parent and compares favorably to previously reported inhibitor, 39 (VX-680). The exhibits low nanomolar potency against both B enzymes, excellent cellular (IC50 < 100 nM), good oral bioavailability. Phenotypic assays show that are...
Novel biotherapeutic glycoproteins, like recombinant monoclonal antibodies (mAbs) are widely used for the treatment of numerous diseases. The N-glycans attached to constant region an antibody have been demonstrated be crucial biological efficacy. Even minor modifications N-glycan structure can dictate potency IgG effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent (CDC).Here, we present development a glycoengineered CHO-K1 host cell line...