A5101722639- Analytical Chemistry and Chromatography
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Methods in Pharmaceuticals
- Listeria monocytogenes in Food Safety
- Drug Solubulity and Delivery Systems
- Salmonella and Campylobacter epidemiology
- Crystallization and Solubility Studies
- Plant-based Medicinal Research
- Thermodynamic properties of mixtures
- Signaling Pathways in Disease
- Microfluidic and Capillary Electrophoresis Applications
- Lanthanide and Transition Metal Complexes
- Prostate Cancer Treatment and Research
- Cardiac electrophysiology and arrhythmias
- Transgenic Plants and Applications
- Cancer-related Molecular Pathways
- Click Chemistry and Applications
- Protease and Inhibitor Mechanisms
- Advanced Drug Delivery Systems
- Antibiotic Resistance in Bacteria
- Chemical and Physical Properties in Aqueous Solutions
- Biosimilars and Bioanalytical Methods
- Pharmaceutical Economics and Policy
- Synthesis and Reactions of Organic Compounds
- Autophagy in Disease and Therapy
Quality Research
2010-2018
National Center for Toxicological Research
2017
United States Food and Drug Administration
2010-2017
Center for Drug Evaluation and Research
2010-2017
United States Department of Health and Human Services
2012-2015
Johns Hopkins University
2000-2011
The University of Texas MD Anderson Cancer Center
2005
Johns Hopkins Medicine
2000
In response to concerns raised about the quality of parenteral vancomycin products, U.S. Food and Drug Administration (FDA) is investigating product all FDA-approved products available in United States. Product was evaluated independently at two FDA Office Testing Research (FDA-OTR) sites. next phase investigation, being done collaboration with National Institute Allergy Infectious Diseases, vivo activity these will be an appropriate animal model. This paper summarizes results investigation...
BACKGROUND There is currently no effective therapy for men with metastatic prostate cancer who relapse after androgen ablation. Prolonged administration of concentrations standard chemotherapeutic agents usually not possible because dose-limiting systemic toxicities. A new strategy to target cytotoxic specifically sites while avoiding toxicity would be develop prodrugs that are inactive when given systemically but become activated processed proteolytically within metastases by...
Cervical cancer cells exhibit an increased requirement for ubiquitin-dependent protein degradation associated with elevated metabolic turnover rate, and specific signaling pathways, notably HPV E6-targeted of p53 PDZ proteins. Natural compounds antioxidant properties including flavonoids triterpenoids hold promise as anticancer agents by interfering degradation. An increasing body evidence indicates that their α-β unsaturated carbonyl system is the molecular determinant inhibition...
Paclitaxel (PTX) is a highly effective and cytotoxic agent widely used for the treatment of several solid tumors. However, PTX shows dose-limiting cytotoxicity in most cases induces drug resistance followed by failure treatments. To enhance therapeutic index given drug, various delivery methods are being explored to systemically deliver sufficient amount desired site. In present study, we designed synthesized two prodrugs conjugating at different sites with an octapeptide (AcGPLGIAGQ) that...
The mechanism of degradation dantrolene in aqueous buffer solutions was studied at various pH values the range 1.2-9.5 and temperatures ranging from 25℃ to 75℃ determine optimum temperature requirements for its stability eventual product performance over human gastrointestinal range. Dantrolene analyzed by reversed phase ultra-performance liquid chromatographic (UPLC). Chromatographic separation achieved on a Waters Acquity UPLC system using BEH C18 analytical column guard column. compounds...
Doxycycline hyclate drug product impurities and rapid quantification using a validated UPLC method.
Abstract Exponential growth of extended‐spectrum β‐lactamase (ESBL)‐producing Escherichia coli in Campylobacter media has become a common problem for the detection chicken meats. We investigated minimum inhibitory concentration 40 ESBL‐producing E. isolates from meats obtained various countries against antibacterial agents Bolton broth (cefoperazone, vancomycin, and trimethoprim). All strains were resistant to cefoperazone whereas 50% them trimethoprim grew broth. found that 20 μg/mL...
A rapid, sensitive, and specific ultra-performance liquid chromatographic (UPLC) method was developed for the simultaneous determination of dantrolene its potential degradation impurities. Chromatographic separation achieved on a Waters Acquity UPLC system using BEH C18 (2.1 × 100 mm, 1.7 µM) analytical column 5 guard column. The compounds were eluted with linear acetonitrile gradient (25–75%) over 3 min buffer composition sodium acetate development, quantitation, forced studies. flow rate...
The development and implementation of advanced analytical technologies is essential for extending the expiry complex drug products stored in Strategic National Stockpiles. Consequently, a novel Ultra High-Performance Liquid Chromatographic (UHPLC) method has been developed analysis atropine its respective impurities to support research platform auto-injectors. This study part larger effort improve efficiency broaden applicability methods medical counter-measure medications. current HPLC...
After synthesis of any chemical moiety; physico-chemical properties that moiety must be investigated. These are essential for predications medicinal, agricultural, industrial, biochemical and biological applications theoretically refractometric measurement is one the best method determination same in drug chemistry. Refractometric measurements important study understanding pharmacokinetics synthesized or isolated moiety. Considering all these things refractrometic 4-amino-1-naphthol [4-AN],...
Overgrowth of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli) on Campylobacter media prevents the latter's selective isolation, thereby making improvement Campylobacter-selective necessary. We evaluated tazobactam (an ESBL inhibitor) to supplement Bolton enrichment broth (Tz-Bolton broth) for isolation in chicken carcass rinses. First, using 20 strains ESBL-producing E. and 13 strains, we found 4 μg/mL be optimal inhibiting while allowing growth all tested strains....
The purpose of this study was to evaluate the impact polystyrene divinylbenzene copolymer HPLC columns on chromatographic performance USP compendial method for doxycycline hyclate. implemented based assessment six defined L21 columns. Modifications were chromatography. validated determination hyclate and its impurities in commercially available drug products. A number different polystyrene-divinylbenzene tested failed provide selectivity resolution impurities. Separation optimally achieved...
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