A5038132959- Cancer Cells and Metastasis
- Counseling Practices and Supervision
- Medical and Biological Sciences
- Cancer, Hypoxia, and Metabolism
- Higher Education Research Studies
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Diverse Education Studies and Reforms
- Mentoring and Academic Development
- Peptidase Inhibition and Analysis
- Single-cell and spatial transcriptomics
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- PARP inhibition in cancer therapy
- CRISPR and Genetic Engineering
- Global Healthcare and Medical Tourism
- Crime Patterns and Interventions
- Tracheal and airway disorders
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Disability Education and Employment
- Child and Adolescent Psychosocial and Emotional Development
- Tissue Engineering and Regenerative Medicine
- Criminal Justice and Corrections Analysis
North Carolina Agricultural and Technical State University
2014-2024
University of Michigan
2014-2023
University of Alabama at Birmingham
2005-2023
U-M Rogel Cancer Center
2021
Michigan Center for Translational Pathology
2014-2020
Michigan Medicine
2020
University of Iowa
2018
The University of Texas at San Antonio
2016
Washington University in St. Louis
1965-2014
Jilin University
2013
The prevalence of brain tumors in males is common but unexplained. While sex differences disease are typically mediated through acute hormone actions, sex-specific tumor rates comparable at all ages, suggesting that factors other than hormones underlie this discrepancy. We found mesenchymal glioblastoma (Mes-GBM) affects more as the result cell-intrinsic sexual dimorphism astrocyte transformation. used astrocytes from neurofibromin-deficient (Nf1(-/-)) mice expressing a dominant-negative...
PARP inhibitors have shown promising results in early studies for treatment of breast cancer susceptibility gene (BRCA)-deficient cancers; however, resistance ultimately develops. Furthermore, the benefit (PARPi) triple-negative cancers (TNBC) remains unknown. Recent evidence indicates that TNBCs, cells display "cancer stem cell" properties are resistant to conventional treatments, mediate tumor metastasis, and contribute recurrence. The sensitivity (CSC) PARPi is unknown.We determined CSCs...
During development, the mammary gland undergoes extensive remodeling driven by stem cells. Breast cancers are also hierarchically organized and cancer cells characterized CD44+CD24low/− or aldehyde dehydrogenase (ALDH) expression. These markers identify mesenchymal epithelial populations both capable of tumor initiation. Less is known about these in non-cancerous glands. From RNA sequencing, ALDH+ ALDH−CD44+CD24− human have epithelial-like mesenchymal-like characteristics, respectively, with...
For various evidences of parental deprivation and family history psychiatric illness, 748 consecutive patients were examined systematically at admission. the sample was characterized stratified for age, sex, socioeconomic marital status; a matched control population then obtained from admissions to general wards same hospital. The groups compared. There no differences in childhood but marked occurrence illness members. It is concluded that if environmental factors turn out outweigh genetic...
Abstract Transcription factor GATA6 is expressed in the fetal and adult adrenal cortex has been implicated steroidogenesis. To characterize role of transcription adrenocortical development function, we generated mice which Gata6 was conditionally deleted using Cre-LoxP recombination with Sf1-cre. The glands conditional knockout (cKO) were small had a thin cortex. Cytomegalic changes evident cKO glands, chromaffin cells ectopically located at periphery glands. Corticosterone secretion...
Police shootings of young Black males that ultimately result in their death have become an all-too-common occurrence this country. The deaths Michael Brown and Eric Gardner highlighted police relations with population. Before viable solutions can be established, a number areas need to addressed relate the historical context which group exist impact current between males, why lives are seemingly given less value by society than those White counterparts, role spirituality religiosity play may...
In the past decade, traditional view of cancers as a homogeneous collection malignant cells is being replaced by model ever increasing complexity suggesting that are complex tissues composed multiple cell types. This tumorigenesis has been well supported growing body evidence indicating most including those derived from blood and solid display hierarchical organization tumor with phenotypic functional heterogeneity at apex this hierarchy capable self-renewal. These "tumor imitating cells" or...
Estrogen-receptor-positive breast tumors are treated with anti-estrogen (AE) therapies but frequently develop resistance. Cancer stem cells (CSCs) high aldehyde dehydrogenase activity (ALDH+ cells) enriched following AE treatment. Here, we show that the interleukin-1β (IL-1β) signaling pathway is activated in ALDH+ cells, and data from single reveals treatment selects for IL-1 receptor (IL1R1)-expressing cells. Importantly, CSC reduced by an IL1R1 inhibitor AE-resistant models. Moreover,...
Abstract Objective Brain organoids are miniaturized in vitro brain models generated from pluripotent stem cells, which resemble full‐sized more closely than conventional two‐dimensional cell cultures. Although mimic the human brain's cell‐to‐cell network interactions, they generally fail to faithfully recapitulate cell‐to‐matrix interactions. Here, an engineered framework, called extracellular matrix (EECM), was developed provide support and interactions developing organoids. Methods We...
Abstract This transcendental phenomenological study described the lived experiences impacting career development among Black women in counselor education specializing rehabilitation counseling. Womanism centralize their voices this inquiry, while social cognitive theory enabled more culturally informed interpretation of experiences. The findings facilitate correct placement group into literature on employment, development, and education, can inform policy changes, curriculum, interventions...
Similarities between stem cells and cancer have implicated mammary in breast carcinogenesis. Recent evidence suggests that normal exist multiple phenotypic states: epithelial, mesenchymal, hybrid epithelial/mesenchymal (E/M). Hybrid E/M particular been metastasis poor prognosis. Mounting also cell phenotypes change throughout the life course, for example, through embryonic development pregnancy. The goal of this study was to use single RNA-sequencing quantify state distributions (NM) gland...
African American men seek mental health services at significantly lower levels than do their White counterparts. The authors explore the role of mentoring for young and discuss impediments to success undergraduate graduate levels. Additionally, examples are presented evidence‐based interventions recommendations effectively working with men.
Cell-cell interactions between tumor cells and constituents of their microenvironment are critical determinants tissue biology therapeutic responses. Interactions glioblastoma (GBM) endothelial (ECs) establish a purported cancer stem cell niche. We hypothesized that genes regulated by these would be important, particularly as targets. Using computational approach, we deconvoluted expression data from mixed physical co-culture GBM ECs identified previously undescribed upregulation the cAMP...
The purpose of this study was to investigate the perceptions African American male counselor educators regarding limited number faculty members in education. Implications and suggestions on how universities can recruit retain are provided. El propósito de este estudio fue investigar las percepciones educadores en consejería afroamericanos con respecto al limitado número miembros entre el profesorado para la educación consejeros. Se proporcionan implicaciones y sugerencias sobre cómo...