A5015387207- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Dysphagia Assessment and Management
- Pancreatitis Pathology and Treatment
- Biliary and Gastrointestinal Fistulas
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Virus-based gene therapy research
- Pediatric Hepatobiliary Diseases and Treatments
- Gastroesophageal reflux and treatments
- Hemophilia Treatment and Research
- Tracheal and airway disorders
- Colorectal Cancer Screening and Detection
- Gastrointestinal Bleeding Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Blood Coagulation and Thrombosis Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- CRISPR and Genetic Engineering
- Bariatric Surgery and Outcomes
- Liver Disease and Transplantation
- Helicobacter pylori-related gastroenterology studies
Thomas Jefferson University Hospital
2018-2025
Thomas Jefferson University
2017-2025
University of Florida
2014-2025
Jefferson Hospital
2024
Yale University
2023
University of Maryland, Baltimore
2023
Jefferson University Hospitals
2020-2021
München Klinik
2020
Florida College
2015-2018
Drexel University
2011-2014
Abstract Gene transfer using adeno-associated virus (AAV) vectors has great potential for treating human disease. Recently, questions have arisen about the safety of AAV vectors, specifically, whether integration vector DNA in transduced cell genomes promotes tumor formation. This study addresses these with high-dose liver-directed AAV-mediated gene adult mouse as a model (80 AAV-injected mice and 52 controls). After 18 months follow-up, did not show significantly higher rate hepatocellular...
Abstract B cell-deficient nonobese diabetic (NOD) mice are protected from the development of spontaneous autoimmune diabetes, suggesting a requisite role for Ag presentation by lymphocytes activation diabetogenic T cell repertoire. This study specifically examines importance cell-mediated MHC class II as regulator peripheral tolerance to islet β cells. We describe construction NOD with an I-Ag7 deficiency confined compartment. Analysis these mice, termed BCIID, revealed presence functionally...
Grape polyphenols can act as antioxidants, antiangiogenics, and selective estrogen receptor (ER) modifiers are therefore especially relevant for gynecological cancers such breast cancer. The major of red wine (resveratrol, quercetin, catechin) have been individually shown to anticancer properties. However, their combinatorial effect on metastatic has not investigated in vivo. We tested the low dietary concentrations resveratrol, catechin cancer progression vitro by analyzing cell...
Untreated cystathionine beta-synthase (CBS) deficiency in humans is characterized by extremely elevated plasma total homocysteine (tHcy>200 microM), with thrombosis as the major cause of morbidity. Treatment vitamins and diet leads to a dramatic reduction thrombotic events, even though patients often still have severe elevations tHcy (>80 microM). To understand difference between extreme hyperhomocysteinemia, we examined two mouse models CBS deficiency: Tg-hCBS Cbs(-/-) mice, mean serum 169...
Background Complete closure of large mucosal defects following colorectal endoscopic submucosal dissection (ESD) with through-the-scope (TTS) clips is oftentimes not possible. We aimed to report our early experience using a novel TTS suturing system for the after ESD. Methods performed retrospective multicenter cohort study consecutive patients who underwent attempted prophylactic defect The primary outcome was technical success in achieving complete closure, defined as < 5 mm residual...
Background: Endoscopic ultrasound (EUS)-guided gastroenterostomy (EUS-GE) is a minimally invasive therapy for patients with gastric outlet obstruction without the risks of surgical bypass and limited long-term efficacy enteral self-expanding metal stent placement. However, due to its novelty, there lack significant data comparing outcomes EUS-GE, based on underlying disease. In this study, we compare EUS-GE benign versus malignant indications. Methods: Consecutive from 12 international,...
Abstract Despite the impressive protection of B cell-deficient (μMT−/−) nonobese diabetic (NOD) mice from spontaneous diabetes, existence mild pancreatic islet inflammation in these indicates that initial autoimmune targeting β cells has occurred. Furthermore, μMT−/− NOD are shown to harbor a latent repertoire diabetogenic T cells, as evidenced by their susceptibility cyclophosphamide-induced diabetes. The quiescence this pool islet-reactive may be consequence impaired activation lymphocytes...
Hemophilia is a bleeding disorder caused by mutations in the genes encoding coagulation Factor VIII (FVIII) or FIX. Current treatment through intravenous infusion of missing protein. The major complication development neutralizing Ab's to clotting factor. Infusion recombinant activated human VII (rhFVIIa), driving procoagulant reactions independently FVIII (hFVIII) hFIX, has been successful such patients and could theory provide hemostasis all hemophilia patients. However, its high cost...
Adeno-associated virus (AAV) vectors demonstrate highly efficient gene transfer to hepatocytes in vivo. One of the remaining obstacles treatment hemophilia B patients with AAV is sensitivity these antibody-mediated neutralization following systemic delivery. Testing and implementation strategies circumvent pre-existing antibodies requires knowledge clearance kinetics from circulation. In this study, were established for serotypes 2 8 cell culture mice. Administration pooled neutralizing...
Abstract EUS-guided gallbladder drainage (EUS-GBD) using lumen apposing metal stents (LAMS) has excellent technical and short-term clinical success for acute cholecystitis (AC). The goals of this study were to determine the long-term outcomes adverse events (AEs) EUS-GBD with LAMS. A multicenter, retrospective was conducted at 18 US tertiary care institutions. Inclusion criteria: any AC patient attempted LAMS minimum 30-day post-procedure follow-up. Long-term defined as absence recurrent...