A5007761528- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Infective Endocarditis Diagnosis and Management
- Thyroid Disorders and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Valve Diseases and Treatments
- Cardiac tumors and thrombi
- Viral Infections and Immunology Research
- Thyroid Cancer Diagnosis and Treatment
- Coronary Artery Anomalies
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Prostate Cancer Treatment and Research
- Cancer Treatment and Pharmacology
- Cardiovascular and Diving-Related Complications
- Cancer Cells and Metastasis
- Liver physiology and pathology
University of Messina
1941-2024
Fondazione Vincenzo Pansadoro
2012-2020
University Hospital of Bern
2018
Creative Research Enterprises (United States)
2015
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2013
University of Turin
2010-2012
Candiolo Cancer Institute
2012
Presidio Ospedaliero
2007-2011
Azienda Ospedaliero Universitaria San Giovanni Battista
2010-2011
Fundación Juan March
2009
Abstract The MET oncogene was causally involved in the pathogenesis of a rare tumor, i.e., papillary renal cell carcinoma, which activating mutations, either germline or somatic, were identified. mutations are rarely found other human tumors, whereas at higher frequencies, is amplified and/or overexpressed sporadic tumors specific histotypes, including osteosarcoma. In this work, we provide experimental evidence that overexpression causes and sustains full-blown transformation osteoblasts....
Abstract RON is a tyrosine kinase receptor that triggers scattering of normal cells and invasive growth cancer on ligand binding. We identified short mRNA, which expressed in human lung, ovary, tissues the gastrointestinal tract, also several cancers, including ovarian carcinomas cell lines from pancreatic leukemias. This transcript encodes truncated protein (short-form RON; sf-RON), lacking most extracellular domain but retaining whole transmembrane intracellular domains. Sf-RON shows...
Coordination of cell death and survival is crucial during embryogenesis adulthood, alteration this balance can result in degeneration or cancer. Growth factor receptors such as Met activate phosphatidyl-inositol-3' kinase (PI3K), a major intracellular mediator growth survival. PI3K then antagonize p53-triggered death, but the underlying mechanisms are not fully understood. We used genetic pharmacological approaches to uncover Met-triggered signaling pathways that regulate hepatocyte...
The FasL-Fas couple is a general death mediator whose activated signals lead to caspase-8 activation and apoptosis in adult hepatocytes. Suppression of cell protective mechanism modulated by the FLICE-Like Inhibitory Protein (FLIP). Although hepatocyte growth factor (HGF) its receptor Met are known mediate survival developing livers, molecular mechanisms involved this process poorly understood. We show here that HGF impairs Fas-triggered primary embryonic hepatocytes correlates with...
Prostate-specific antigen (PSA), considered only an established marker for the detection of prostate cancer, has been identified as a member (hK3) human kallikrein family serine proteases and now, it is known that PSA not specific to prostate, semen, gender. Increased serum levels have reported also in cardiovascular patients both elevated well diminished during acute myocardial infarction (AMI). Preliminary observations concluded when elevation prostate-specific occurs AMI, seems relate...
Bone metastases represent a common and severe complication in breast cancer, the involvement of cancer stem cells (CSCs) promotion bone metastasis is currently under discussion. Here, we used human-in-mice model to study formation due primary CSCs-like colonisation. Primary CD44+CD24− were transduced by luciferase-lentiviral vector injected through subcutaneous intracardiac (IC) routes non-obese/severe-combined immunodeficient (NOD/SCID) mice carrying human implants. The localisation was...