Smita Chandra

ORCID: 0000-0002-0652-4708
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About
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Research Areas
  • Hematological disorders and diagnostics
  • Cancer Cells and Metastasis
  • Autoimmune and Inflammatory Disorders Research
  • Cancer Immunotherapy and Biomarkers
  • Sarcoma Diagnosis and Treatment
  • Thyroid Cancer Diagnosis and Treatment
  • Research on Leishmaniasis Studies
  • Lung Cancer Diagnosis and Treatment
  • Inflammatory Biomarkers in Disease Prognosis
  • Cervical Cancer and HPV Research
  • Antifungal resistance and susceptibility
  • Hemoglobinopathies and Related Disorders
  • Fungal Infections and Studies
  • Cancer Diagnosis and Treatment
  • Immune Cell Function and Interaction
  • Voice and Speech Disorders
  • Viral Infections and Vectors
  • Bone and Joint Diseases
  • Lymphoma Diagnosis and Treatment
  • Tracheal and airway disorders
  • Head and Neck Anomalies
  • Parvovirus B19 Infection Studies
  • Restraint-Related Deaths
  • Cancer Genomics and Diagnostics
  • Diagnosis and treatment of tuberculosis

Swami Rama Himalayan University
2015-2024

Institute of Medical Sciences
2014-2024

Himalayan Institute of Yoga Science and Philosophy
2013-2024

Samsung (United States)
2021-2023

Creative Commons
2021

Jawaharlal Institute of Post Graduate Medical Education and Research
2012

Govind Ballabh Pant University of Agriculture and Technology
2004

Banaras Hindu University
1981-1992

University of Wisconsin–Madison
1976-1990

Studies have compared the role of bone marrow aspirate cytology and trephine biopsy for diagnosing various hematological disorders but fewer studies relative value imprint with biopsy. The present study was conducted to compare aspirate, touch formulate an effective rapid method wide spectrum diseases. included total 565 cases examination from January 2006 till May 2010. All smears sections were reviewed morphological details findings on each other. diagnostic accuracy 77.5%, 83.7% that...

10.4081/hr.2011.e22 article EN cc-by Hematology Reports 2011-10-21

BackgroundMalaria may be associated with complications which avoided by early diagnosis and treatment. Microscopic showing presence of malarial parasites is needed for confirmation at times unreliable requires technical expertise. The present study was conducted to statistically analyze the haematological parameters including platelet indices can give initial hint infection therefore prompt laboratory physician active search parasite microscopically. MethodsA retrospective included 334 cases...

10.4084/mjhid.2013.009 article EN Mediterranean Journal of Hematology and Infectious Diseases 2013-01-02

<b>Aim:</b> This study was conducted to assess the role of cytology in diagnosis lung lesions and compare it with histopathology. It also intended evaluate rapid on site evaluation (ROSE) as an adjunct cytological lesions.<br> <b>Materials Methods:</b> The included all cases lesions, which were diagnosed followed by histopathology over a period 2½ years along ROSE, wherever possible.<br> <b>Results:</b> Cytology done total 782 various this cyto-histopathological correlation available 215...

10.4103/0970-9371.151128 article EN cc-by-nc-sa Journal of Cytology 2014-01-01

Atypia of undetermined significance (AUS) or follicular lesion (FLUS) Bethesda system for reporting thyroid cytopathology has emerged as most controversial category due to its heterogeneity and inconsistent usage. Initially associated risk malignancy was estimated be about 5-15%, but eventually different results have been obtained across institutions variable follow-ups interpretation. The present study conducted evaluate the rate along with appropriate management in this category.The...

10.4103/joc.joc_234_16 article EN cc-by-nc-sa Journal of Cytology 2017-01-01

Angiogenesis plays an important role in progression of tumor with vascular endothelial growth factor (VEGF) being key proangiogenic factor. It was intended to study angiogenesis different hematological malignancies by quantifying expression VEGF and MVD bone marrow biopsy along serum levels observing its change following therapy. The included 50 cases which were followed for one month after initial therapy 30 controls. All them subjected immunostaining anti-VEGF VIII antibodies on the...

10.1155/2016/5043483 article EN Bone Marrow Research 2016-02-22

Objectives. The present study was conducted to categorise the morphological features on bone marrow aspirate cytology into common, uncommon, and atypical in a nonendemic region which would be helpful clinching an early correct diagnosis especially clinically unsuspected cases. Methods. were categorized cases of leishmaniasis from non endemic region. Results. Out total 27 cases, 77.7% residents places at height 500 m or above fever most common presentation followed by hepatosplenomegaly....

10.1155/2013/861032 article EN cc-by Journal of Tropical Medicine 2013-01-01

The differentiation of hemophagocytic lymphohistiocytosis (HLH) with other causes hemophagocytosis is essential as HLH life-threatening condition and requires definite clinical biochemical criteria for its diagnosis.The present study was conducted to on bone marrow aspirates observe if there any difference examination between non cases showing hemophagocytosis.The reviewed all the aspirate evidence in which at least three smears 500 nucleated cells were observed every case. provisionally...

10.4103/2141-9248.141515 article EN Annals of Medical and Health Sciences Research 2014-01-01

Transbronchial needle aspiration (TBNA) has an established role in diagnosis of hilar and mediastinal lesions. Rapid on-site evaluation (ROSE) TBNA smears can determine the adequacy that obviate need for repeat procedures, thus avoiding added cost. There is paucity data from India showing efficacy cost-effectiveness ROSE. Hence, this study was carried out to assess efficacy, feasibility cost implications ROSE assisted TBNA.Forty consecutive patients undergoing were enrolled performed on...

10.5005/ijcdas-55-3-141 article EN The Indian Journal of Chest Diseases and Allied Sciences 2022-06-16

Recently, platelet indices have been evaluated to determine their utility in knowing the mechanism of thrombocytopenia. This study was conducted analyze role mean volume (MPV) as a guide or an indicator for bone marrow disease thrombocytopenic patients. All patients with thrombocytopenia various causes followed by examination were divided into two groups, one group and another without disease, depending on pathophysiology. The MPV statistically analyzed both groups assess its these Mean...

10.1111/j.1751-553x.2009.01212.x article EN International Journal of Laboratory Hematology 2010-01-11

Bone marrow metastasis is an important presentation of solid tumors affecting their prognosis and management. The present study was conducted to analyze the hematological indicators which can predict along with comparison bone aspirate, touch imprint trephine biopsy, define effective method for its early diagnosis. showed that there statistical significant difference in mean platelet volume (MPV) distribution width (PDW) between cases controls (P<0·001) MPV at cut off <8 fl significantly...

10.1179/102453310x12647083621001 article EN Hematology 2010-09-23

A 38-year-old woman who presented with unexplained fever and pancytopenia was subjected to a bone marrow examination. Her aspirate smear showed no obvious pathological finding except for the presence of hemophagocytosis mild plasmacytosis. In view hemophagocytosis, thorough examination conducted revealed histoplasmosis. She advised undergo evaluation her immunological status, she tested positive human immunodeficiency virus (HIV) infection. This case highlights that in may be an early sign...

10.5045/kjh.2012.47.1.77 article EN cc-by-nc The Korean Journal of Hematology 2012-01-01

ABSTRACT: Penile involvement was seen in 19.5% of 261 patients, aged 11 to 30 years, with tinea cruris. It more common patients under the age (20 years (p &lt; 0.05). The increased incidence is probably related use langota. a semiocclusive undergarment that may favor growth dermatophytes.

10.1111/j.1365-4362.1981.tb00419.x article EN International Journal of Dermatology 1981-03-01

To evaluate the addition of titanium dioxide (TiO2) nanoparticles and cetylpyridinium chloride (CPC) on compressive strength antibacterial activity conventional glass-ionomer cement (GIC).TiO2 enriched GIC was prepared by adding 3% TiO2 (w/w) into powder component GIC. CPC containing developed incorporating 1% powder. Samples were segregated three groups: with nanoparticles, unmodified Compressive assessed using universal testing machine cylindrical specimens made from each material....

10.17796/1053-4625-43.1.8 article EN Journal of Clinical Pediatric Dentistry 2018-10-05

Image-guided fine-needle aspiration has emerged as an effective diagnostic tool for precise diagnosis of deep-seated lesions. Although occasional studies have made attempt to classify the gallbladder carcinoma on cytology, literature lacks standardized cytological nomenclature system used it. The present study was conducted role cytology (FNAC) in lesions with cytomorphological classification.The included cases image-guided FNAC over a period 3½ years. An categorize basis architectural and...

10.4103/cytojournal.cytojournal_5_18 article EN CytoJournal 2019-01-22

Iron Deficiency Anaemia (IDA) and β-Thalassaemia Minor (BTM) are considered to be important cause of microcytic hypochromic anaemia. Studies have evaluated various red cell parameters which easily available on electronic counters for discrimination IDA BTM in different ethnic populations. The analysis previously established discriminative indices with new cut-off also been done by studies may relevant their set population differentiation.The study was conducted propose a modified score...

10.7860/jcdr/2016/17672.7843 article EN cc-by-nc-nd JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH 2016-01-01

Finding fruiting bodies and hyphae of Aspergillus species in a routine cervicovaginal Pap smear is rare occurrence. When encountered, it important to distinguish between true infection contamination. The body also plays very role distinguishing the various species.A 52-year-old woman underwent gynecologic examination. Her per-vaginal per-speculum examinations were unremarkable. showed atrophic changes with few acute inflammatory cells. However, large number many observed smears. Close...

10.1159/000325131 article EN Acta Cytologica 2009-01-01

Adult cases of visceral leishmaniasis (VL), predominantly males, have been reported in the past decade from natives high altitude areas North Indian state Uttarakhand. We report 14 pediatric VL, who were diagnosed and treated successfully over 7 years. All these children born brought up this area had never visited any endemic areas. High prevalence pallor, splenohepatomegaly, thrombocytopenia poor association with HIV are cardinal features VL region. Although newer drugs become available,...

10.1093/tropej/fmw056 article EN Journal of Tropical Pediatrics 2016-08-30

Birth abnormalities like cleft lip and palate account for about 1.4 per 1000 live births in India. These are seen to be associated with a high incidence of eosinophilia which delays the surgical management these patients.The aim this paper is study hematological parameters patients palate.A total 223 cases were taken up study. Hematological including hemoglobin, leukocyte count, differential absolute eosinophil red cell indices studied.Anemia was found 182/223 (81.63%) most commonly...

10.1097/scs.0b013e3182a2eb3c article EN Journal of Craniofacial Surgery 2013-11-26

Abstract Introduction: Human papilloma virus (HPV) which is causative factor for cervical cancer may interact with p16 leading to malignant transformation of epithelial cells. The present study was conducted assess the immunoexpression INK4a in premalignant and lesions cervix correlate it HPV 16 expression. It also intended various risk factors be associated this north Himalayan region India. Material Methods: included 50 cases controls diagnosed on histopathology over a period one year. All...

10.4103/sajc.sajc_118_17 article EN cc-by-nc-nd South Asian Journal of Cancer 2018-10-01

Von Meyenburg complex is a benign biliary hamartoma observed in approximately 3% of the autopsies conducted. These hamartomas are small, multiple and can be seen anywhere liver. There usually no abnormality liver function tests, patient mostly asymptomatic. They serve as diagnostic dilemma, particularly during metastatic workup suspected cancer patients. Imaging studies noncontributory, biopsy necessary for definite diagnosis. We present here middle-aged North Indian male who underwent to...

10.4103/jlp.jlp_55_19 article EN cc-by-nc-nd Journal of Laboratory Physicians 2019-10-01

Serum interleukin (IL)-6 has been found to be associated with sleep quality, mood, and survival in patients solid tumors. Results these studies were confounded by knowledge of diagnosis study subjects. Moreover, such data among subjects hematological malignancies regarding restless legs syndrome is limited. The present was, therefore, conducted assess the depression, leg if there any role IL6 it.Sixty-six having malignancy included this after excluding potential confounders. Sleep quality...

10.4103/jnrp.jnrp_159_18 article EN Journal of Neurosciences in Rural Practice 2018-10-17
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