A5015687995- Colorectal Cancer Treatments and Studies
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- Nuclear Structure and Function
- Cancer Genomics and Diagnostics
- Hepatitis C virus research
- Biochemical and Molecular Research
- Virus-based gene therapy research
- Hepatocellular Carcinoma Treatment and Prognosis
- Enzyme Structure and Function
- Bacteriophages and microbial interactions
- DNA and Nucleic Acid Chemistry
- DNA Repair Mechanisms
- Respiratory viral infections research
- Radiomics and Machine Learning in Medical Imaging
- RNA Research and Splicing
- Microtubule and mitosis dynamics
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Herpesvirus Infections and Treatments
- Hepatitis B Virus Studies
- RNA Interference and Gene Delivery
- Cellular transport and secretion
- Renal cell carcinoma treatment
Istituto Oncologico Veneto
2019-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
University of Padua
2015-2021
Intersectin 1-short (ITSN1-s) is a 1220 amino acid ubiquitously expressed scaffold protein presenting multidomain structure that allows to spatiotemporally regulate the functional interaction of plethora proteins. Besides its well-established role in endocytosis, ITSN1-s involved regulation cell signaling and implicated tumorigenesis processes, although pathways are still poorly understood. Here, we identify as nucleocytoplasmic trafficking protein. We show that, by binding importin (IMP)α,...
Respiratory syncytial virus (RSV) is an important human pathogen, which infects respiratory tract epithelial cells causing bronchiolitis and pneumonia in children the elderly. Recent studies have linked RSV matrix (M) ability to self-interaction viral budding. However, M has been crystalized both as a monomer dimer, no formal proof exists date that it forms dimers cells. Here, by using combination of confocal laser scanning microscopy bioluminescent resonant energy transfer applied...
Background: First-line decision making is the key to successful care of mCRC patients and RAS/BRAF status crucial select best targeted agent. In hub centers, a relevant proportion referred from small volume centers may not have standard tissue-based (STB) molecular results available at time first visit (T0). Liquid biopsy (LB) help circumvent these hurdles. Methods: A monoinstitutional prospective head-to-head comparison LB versus (vs.) STB testing was performed in real-world setting....
Despite the introduction of directly acting antivirals (DAAs), for treatment hepatitis C virus (HCV) infection, their cost, patient compliance, and viral resistance are still important issues to be considered. Here, we describe generation a novel JFH1-based HCV subgenomic replicon double reporter cell line suitable testing different antiviral drugs therapeutic interventions. This cells allowed rapid accurate quantification growth/viability RNA replication, thus discriminating specific from...
Human cytomegalovirus (HCMV) genome replication is a complex and still not completely understood process mediated by the highly coordinated interaction of host viral products. Among latter, six different proteins form complex: single-stranded DNA binding protein, trimeric primase/helicase two subunit polymerase holoenzyme, which in turn contains catalytic subunit, pUL54, dimeric processivity factor ppUL44. Being absolutely required for representing potential therapeutic targets, both...
3524 Background: The predictive and prognostic value of current biomarkers for guiding the treatment stage II colon cancer (CC) is very limited. Here, we aimed to develop a transcriptional signature high-risk CC patients undergoing adjuvant with either 3 or 6 months FOLFOX4/CAPOX within framework phase III TOSCA Italian trial. Methods: We conducted an observational retrospective study based on trial database, matching 62 who relapsed did not. criteria included center recruitment, pT stage,...
ABSTRACT Human cytomegalovirus (HCMV) is a leading cause of severe diseases in immunocompromised individuals, including AIDS and transplanted patients, congenitally infected newborns. Despite the availability several antiviral drugs, their utility limited by poor bioavailability, toxicity, resistant strains emergence. Therefore, it crucial to identify new targets therapeutic intervention. The dimerization HCMV DNA polymerase processivity factor UL44 plays an essential role viral life cycle...
48 Background: First-line decision making is the key to successful management of mCRC patients (pts). RAS/BRAF status essential choose best targeted agent. In hub centers, a not negligible proportion pts referred from elsewhere may have standard tissue-based (STB) molecular results available at time first oncologic visit (T0). LB help circumvent these hurdles. Methods: A monoinstitutional prospective head-to-head comparison versus (vs) STB testing was conducted in real-world setting....