A5101528647- Bacterial biofilms and quorum sensing
- Anesthesia and Pain Management
- Treatment of Major Depression
- Cardiac, Anesthesia and Surgical Outcomes
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Anesthesia and Sedative Agents
- Antifungal resistance and susceptibility
- Nausea and vomiting management
- Growth Hormone and Insulin-like Growth Factors
- Problem and Project Based Learning
- Pituitary Gland Disorders and Treatments
- 3D Printing in Biomedical Research
- Hip and Femur Fractures
- Anesthesia and Neurotoxicity Research
- Diabetes Treatment and Management
- Vitamin D Research Studies
- Cardiac Valve Diseases and Treatments
- Chemotherapy-related skin toxicity
- Trigeminal Neuralgia and Treatments
- Epilepsy research and treatment
- Diet and metabolism studies
- Aortic aneurysm repair treatments
- Antibiotic Use and Resistance
- Migraine and Headache Studies
All India Institute of Medical Sciences Bhubaneswar
2017-2025
All India Institute of Medical Sciences
2018-2025
Vinayaka Missions Medical College and Hospitals
2024
Community Link
2024
National Center for Cancer Care and Research
2023
Hamad Medical Corporation
2023
National Taiwan University Hospital
2023
National Taiwan University
2023
Qatar University
2023
Sriram Chandra Bhanja Medical College Hospital
2022
As a member of the normal human oral microbiota, fungus Candida albicans is often found in association with Streptococcus gordonii, dental plaque forming bacteria. Evidence suggests that S. gordonii serves as facilitator C. adherence to tissues, which represents clinically relevant problem, particularly for immunocompromised individuals could subsequently develop fungal infections. In this study we describe development relatively simple and economical vitro model allows growth mixed...
Biofilm-associated Pseudomonas aeruginosa infections remain a significant clinical challenge since the conventional antibiotic treatment or combination therapies are largely ineffective; and new approaches needed. To circumvent major challenges associated with discovery of antimicrobials, we have screened library compounds that commercially available approved by FDA (Prestwick Chemical Library) against P. for effective antimicrobial anti-biofilm activity. A preliminary screen Prestwick...
Proton pump inhibitors, by elevating plasma gastrin, can influence glucose-insulin homeostasis. Because there are no controlled clinical trials, the present study was planned to evaluate effect of pantoprazole, a proton inhibitor, on homeostasis in patients with type 2 diabetes (T2DM). In this 12-wk, randomized, double-blind, placebo-controlled study, T2DM were allocated either pantoprazole or placebo treatment an equal ratio. Alterations glycosylated hemoglobin (HbA1c), fasting glucose,...
The oral cavity serves as a nutrient-rich haven for over 600 species of microorganisms. Although many are essential to maintaining the microbiota, some can cause infections such caries, periodontitis, mucositis, and endodontic infections, this is further exacerbated with dental implants. Most these mixed in nature associated biofilm mode growth. Here, after optimization different parameters including cell density, growth media, incubation conditions, we have developed an vitro model C....
Dexmedetomidine, an alpha-2 agonist, has been used for attenuation of hemodynamic response to laryngoscopy but not through the nebulized route. We evaluated effects preoperative dexmedetomidine nebulization on and intubation examined intraoperative anesthetic-analgesic requirements recovery outcomes.Overall, 120 American Society Anesthesiologists I & II adult patients (of either gender) undergoing elective surgeries requiring tracheal intubation, were randomized receive (1 µg/kg in 3-4 ml...
Drug interactions are crucial in understanding the efficacy and safety of co-administered antiepileptic drugs, which underscores need for cautious prescribing close monitoring patients receiving multiple antiepileptics. This study aims to investigate drug between carbamazepine(CBZ) levetiracetam(LEV) whether CBZ toxicity is LEV drug-dose or dose-ratio-dependent(LEV:CBZ). The present record-based case-control analyzed data from 158 patients. A univariate analysis was done identify association...
ABSTRACT Fungal infections constitute a major threat to an escalating number of critically ill patients. Fungi are eukaryotic organisms and, as such, there is limited armamentarium antifungal drugs, which leads high mortality rates. Moreover, fungal often associated with the formation biofilms, contribute virulence and further complicate treatment due level drug resistance displayed by sessile cells within these microbial communities. Thus, biofilm etiology represents formidable unmet...
Abstract Introduction The debate about observing total versus free serum valproate levels for therapeutic drug monitoring (TDM) has been unresolved decades. This study was planned to assess the agreement between and advantage of one method over other in TDM. Methods present cross‐sectional done on 93 patients with bipolar disorder. intraclass correlation coefficient, Bland Altman analysis, Lin's concordance analysis were concentrations. Linear polynomial models constructed evaluate relation...
Background: Growth hormone (GH) levels following oral glucose tolerance test (OGTT) at 12 weeks or later after surgery have been accepted as the most reliable parameter for defining remission and/or cure in patients with acromegaly. However, role of random GH predicting immediate postoperative period using modern criteria is not known. This study was undertaken to evaluate first 5 days an early predictive tool long-term acromegaly transsphenoidal pituitary (TSS).Patients and Methods:...
Abstract Background There is a need for newer therapies chronic painful diabetic neuropathy as the existing drugs have their own limitations. Clinical trials on low‐dose naltrexone (1‐5 mg/d) showed efficacy and safety in certain conditions, but not neuropathy. Hence present study was planned. Methods Sixty‐seven participants with were randomized to receive either 2 mg or 10 amitriptyline daily following 2‐week run‐in period. The followed up every weeks total of 6 weeks. Up‐titration done...