ABSTRACT Objective To study the anticraving efficacy of high‐frequency repetitive transcranial magnetic stimulation (rTMS) right dorsolateral pre‐frontal cortex (DLPFC) in patients with alcohol dependence. Methods We performed a prospective, single‐blind, sham‐controlled involving 45 dependence syndrome (according to ICD‐10 DCR), Clinical Institute Withdrawal Assessment Alcohol (CIWA‐Ar) scores ≤10. Patients were allocated active and sham rTMS 2 : 1 ratio, such that 30 received 15 DLPFC (10...

The objective of this study was to compare the anticraving efficacy high-frequency repetitive transcranial magnetic stimulation (rTMS) right versus left dorsolateral prefrontal cortex (DLPFC) in patients with alcohol dependence. Twenty dependence syndrome were randomly allocated receive either or rTMS over DLPFC (10 sessions at 10 Hz frequency; 20 trains per session; 4.9 seconds train and intertrain interval 30 seconds) assessed on Alcohol Craving Questionnaire (ACQ-NOW) measure craving....

In treatment-resistant schizophrenia (TRS), Clozapine is only approved treatment with undesirable side-effects, warranting better alternatives. Our hypothesis acute followed by maintenance Electroconvulsive Therapy (M-ECT) will be comparable in efficacy and safety to TRS.In this open-label trial, 60 TRS patients were randomized equally M-ECT (following an acute-course) or Clozapine. Positive Negative Syndrome Scale (PANSS), Clinical Global Impression Schizophrenia (CGI-SCH), Montreal...

Abstract Background Data on intensive care unit (ICU) related psychiatric morbidity from Low Middle-Income Countries are sparse. We studied the ICU posttraumatic stress symptoms (PTSS), anxiety, and depression in a cohort of patients Eastern India. Methods included adults admitted more than 24 h to mixed ICU. PTSS, were assessed by telephonic or face interviews using Impact Events-r (IES-r) Hospital anxiety (HADS), respectively, at 0, 7,14, 30, 90 180 days discharge. The loss follow up was...

Drug interactions are crucial in understanding the efficacy and safety of co-administered antiepileptic drugs, which underscores need for cautious prescribing close monitoring patients receiving multiple antiepileptics. This study aims to investigate drug between carbamazepine(CBZ) levetiracetam(LEV) whether CBZ toxicity is LEV drug-dose or dose-ratio-dependent(LEV:CBZ). The present record-based case-control analyzed data from 158 patients. A univariate analysis was done identify association...

Abstract Epilepsy treatment is challenging because of multiple impediments like lack efficacy monotherapy, adverse drug reactions, and different comorbidities. Add‐on therapy to first‐line antiepileptics may be the option overcome therapeutic hurdles. The present randomized, double‐blind, add‐on placebo‐controlled clinical trial was conducted evaluate effect melatonin in generalized epilepsy with onset motor seizure adults. control group ( n = 52) received placebo, test (3 mg/day) valproate...

Abstract Introduction The debate about observing total versus free serum valproate levels for therapeutic drug monitoring (TDM) has been unresolved decades. This study was planned to assess the agreement between and advantage of one method over other in TDM. Methods present cross‐sectional done on 93 patients with bipolar disorder. intraclass correlation coefficient, Bland Altman analysis, Lin's concordance analysis were concentrations. Linear polynomial models constructed evaluate relation...

Objectives This study aimed to assess the effectiveness of a video-assisted educational program on knowledge, attitude, and stigma toward modified electroconvulsive therapy (ECT) among primary caregivers patients with psychotic disorders. Methods experimental was conducted at Department Psychiatry tertiary care hospital in India 94 adult disorder. Participants group (n = 47) received 15-minute ECT addition standard care, those control only care. The online platform used collect data...

Nutraceuticals like alpha-lipoic acid (ALA) may have potential benefits as prophylactic agents for adolescent migraine, with fewer adverse events than existing medications. The present study was conducted to evaluate the safety and efficacy of add-on ALA prophylaxis in migraine. A randomized, open-label, clinical trial 60 migraineurs, who were randomized receive flunarizine or an ALA. evaluation frequency severity responder rate, Pediatric Migraine Disability Assessment (PedMIDAS) scoring,...

The role of low-frequency repetitive transcranial stimulation (rTMS) in drug-resistant epilepsy (DRE) has been conflicting and inconclusive previous clinical trials. This meta-analysis evaluated the efficacy rTMS on seizure frequency epileptiform discharges DRE.A standard protocol was registered International Prospective Register Ongoing Systematic Reviews (PROSPERO: CRD42018088544). After performing a comprehensive literature search using specific keywords MEDLINE, Cochrane database,...

Abstract Introduction Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia characterised by the loss of REM muscle atonia and enactment dreams. Acute RBD associated with alcohol withdrawal syndrome known, but studies are limited, particularly on its neurobiological underpinnings management alongside state. This work attempts to address this using case study relevant literature review. Case Presentation A 40‐year‐old male dependence (for 20 years) reported new‐onset...

The authors studied cerebral hemodynamics in alcohol dependence and evaluated their changes with application of high-frequency rTMS. A prospective, single-blind, randomized, parallel-group, sham-controlled clinical study was conducted patients (DSM-IV-TR). population comprised 25 subjects each active rTMS, sham healthy control groups. At baseline, hemodynamic indices were measured transcranial Doppler sonography. Subjects the rTMS group received 10 sessions daily; administered same...