About
Contact & Profiles
A5085397844
Research Areas
- Cancer therapeutics and mechanisms
- Antibiotic Resistance in Bacteria
- Bioactive Compounds and Antitumor Agents
University of Ljubljana
2023
A new series of dual low nanomolar benzothiazole inhibitors bacterial DNA gyrase and topoisomerase IV were developed. The resulting compounds show excellent broad-spectrum antibacterial activities against Gram-positive Enterococcus faecalis, faecium multidrug resistant (MDR) Staphylococcus aureus strains [best compound minimal inhibitory concentrations (MICs): range, <0.03125–0.25 μg/mL] the Gram-negatives Acinetobacter baumannii Klebsiella pneumoniae (best MICs: 1–4 μg/mL). Lead 7a was...
10.1021/acs.jmedchem.2c01905
article
EN
cc-by
Journal of Medicinal Chemistry
2023-03-06
Coming Soon ...