A5081176785- Microfluidic and Bio-sensing Technologies
- Blood properties and coagulation
- Erythrocyte Function and Pathophysiology
- Liquid Crystal Research Advancements
- Microfluidic and Capillary Electrophoresis Applications
- Block Copolymer Self-Assembly
- Nanopore and Nanochannel Transport Studies
- Electrohydrodynamics and Fluid Dynamics
- Surfactants and Colloidal Systems
- Aerosol Filtration and Electrostatic Precipitation
- Lipid Membrane Structure and Behavior
- Material Dynamics and Properties
- Catalysis for Biomass Conversion
- Micro and Nano Robotics
- Nonlinear Dynamics and Pattern Formation
- Membrane Separation Technologies
- Digital Imaging for Blood Diseases
- Graphene and Nanomaterials Applications
- Pickering emulsions and particle stabilization
- Cyclone Separators and Fluid Dynamics
- Infant Nutrition and Health
- Particle Dynamics in Fluid Flows
- Catalysis and Hydrodesulfurization Studies
- Thermal Radiation and Cooling Technologies
- Catalysts for Methane Reforming
Nanjing Tech University
2022-2024
The Synergetic Innovation Center for Advanced Materials
2022
Forschungszentrum Jülich
2015-2019
State Key Laboratory of Polymer Physics and Chemistry
2010-2018
KU Leuven
2014-2018
Chinese Academy of Sciences
2010-2018
Beijing National Laboratory for Molecular Sciences
2010-2018
Ernst Ruska Centre
2016
Institute of Chemistry
2010
Deterministic lateral displacement (DLD) devices have great potential for the separation and sorting of various suspended particles based on their size, shape, deformability, other intrinsic properties. Currently, basic idea mechanism is that structure geometry DLDs uniquely determine flow field, which in turn defines a critical particle size within device. We employ numerical simulations using coarse-grained mesoscopic methods two-dimensional models to elucidate dynamics both rigid...
Abstract Recent advances in cell sorting aim at the development of novel methods that are sensitive to various mechanical properties cells. Microfluidic technologies have a great potential for sorting; however, design many micro-devices is based on theories developed rigid spherical particles with size as separation parameter. Clearly, most bioparticles non-spherical and deformable therefore exhibit much more intricate behavior fluid flow than spheres. Here, we demonstrate use cells’...
Construction of well-ordered two-dimensional (2D) and three-dimensional (3D) assemblies using one-dimensional (1D) units is a hallmark many biointerfaces such as skin. Mimicking the art difunctional properties biointerfaces, which skin exhibits defense shelter materials, has inspired development smart responsive biomimetic interfaces. However, programming long-range ordering 1D base materials toward vigorous control over 2D 3D hierarchical structures material remains daunting challenge. In...
We present a systematic dissipative particle dynamics (DPD) study on the phase behavior, structure, and of rodlike mesogens. In addition to rigid fused-bead-chain model with RATTLE constraint method, we also construct semirigid in which flexibility is controlled by bending constant kϕ. Using this notation, has an infinite kϕ=∞. Within parameter space studied, both two kinds models exhibit nematic smectic-A phases isotropic solid phases. All transitions are accompanied discontinuities...
The application of the deterministic lateral displacement approach in microfluidics to deformability-based sorting cells is explored. Mesoscale hydrodynamics simulations are employed show that this requires large flow-induced cell deformation trajectory-distinguishing flow region.
Deterministic lateral displacement (DLD) microfluidic devices promise versatile and precise processing of biological samples. However, this prospect has been realized so far only for rigid spherical particles remains limited cells due to the complexity cell dynamics deformation in flow. We employ mesoscopic hydrodynamics simulations red blood (RBCs) DLD with circular posts better understand interplay between behavior complex flow sorting capabilities such devices. construct a mode diagram...
Dissipative particle dynamics simulations have been conducted to study the anchoring transitions of nematic liquid crystals in presence a rod–coil amphiphilic monolayer at aqueous–liquid crystal interface. Instead amphiphile interfacial coverage, repulsion interaction parameter (aMR) between mesogens and rod blocks amphiphiles is used as tunable quantitative control transition. Depending on complicated interplay interactions packing effects, we observed novel transition sequence...
Many biological and medical applications of microfluidic devices involve handling blood at different concentrations (hematocrit). However, there is a lack understanding how high hematocrit influences device performance. The authors study the effect on performance sorting that are based deterministic lateral displacement, through extensive experiments simulation. They successfully identify several physical mechanisms responsible for changes in with hematocrit.
Dissipative particle dynamics simulations have been performed to study the coassembly behavior of short carbon nanotubes and diblock copolymers in concentrated solutions by modeling as cylindrical nanoparticles (CNPs). With varying hydrophobic/hydrophilic ratio (AmBn) at fixed concentration chain length (m + n = 15), influence addition CNPs on lyotropic mesophases including micellar, hexagonal, lamellar phases has examined detail, comparison with reference systems involving spherical (SNPs)....
The accurate and general formulation of the critical separation size is crucial for effective design application passive microfluidic devices. However, current formulas deterministic lateral displacement (DLD) technique are inadequate in accounting its structural complexity. To address this limitation, we conducted mesoscopic hydrodynamics simulations to assess performance various parallelogram-type circular post arrays. Based on simulation results, developed a new layout-dependent formula...
Dissipative particle dynamics simulations have been applied to study the temperature dependent anchoring and wetting behavior of thermotropic liquid crystals (LCs) in presence a rod-coil amphiphilic monolayer at aqueous-LC interface. Upon cooling nematic phase, thermally-induced transition from homeotropic through tilted planar has observed. The growth propagation smectic order interfaces bulk LCs are demonstrated be mainly responsible for this novel sequence. In particular, when complete...
Rational design of thermotropic liquid crystal (LC)-based sensors utilizing different mesophases holds great promise to open up novel detection modalities for various chemical and biological applications. In this context, we present a dissipative particle dynamics study explore the unique anchoring behavior nematic smectic LCs at amphiphile-laden aqueous-LC interface. By increasing surface coverage amphiphiles, two distinct sequences, continuous planar-tilted-homeotropic transition...
Sorting cells based on their intrinsic properties is a highly desirable objective, since changes in cell deformability are often associated with various stress conditions and diseases. Deterministic lateral displacement (DLD) devices offer high precision for rigid spherical particles, while success sorting deformable particles remains limited due to the complexity of traversal DLDs. We employ mesoscopic hydrodynamics simulations demonstrate prominent advantages sharp-edged DLD obstacles...
Deterministic lateral displacement (DLD) microfluidic devices promise versatile and precise processing of biological samples. However, this prospect has been realized so far only for rigid spherical particles remains limited cells due to the complexity cell dynamics deformation in flow. We employ mesoscopic hydrodynamics simulations red blood (RBC) DLD with circular posts better understand interplay between behavior complex flow sorting capabilities such devices. construct a mode diagram RBC...
Pillar shape exploration in deterministic lateral displacement (DLD) technique holds great promise for developing high-performance microfluidic devices with versatile sorting schemes. A recent innovative design using filter-like micropillars was proposed to improve cell separation, but its significance might be greatly underestimated due an inaccurate understanding of the underlying mechanism. In this study, we employ mesoscopic hydrodynamic simulations explore movement and separation rigid...