A5087136101- Respiratory viral infections research
- Leptospirosis research and findings
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- Viral Infections and Vectors
- HIV Research and Treatment
- Herpesvirus Infections and Treatments
- HIV/AIDS Research and Interventions
- Bartonella species infections research
- Parvovirus B19 Infection Studies
- Pneumonia and Respiratory Infections
- Veterinary medicine and infectious diseases
- Viral gastroenteritis research and epidemiology
- Viral-associated cancers and disorders
- Hepatitis Viruses Studies and Epidemiology
- Virology and Viral Diseases
- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- Vibrio bacteria research studies
- Vector-borne infectious diseases
- Thermography and Photoacoustic Techniques
- Syphilis Diagnosis and Treatment
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- Genomics and Phylogenetic Studies
Thammasat University
2019-2025
Siriraj Hospital
1999-2019
Mahidol University
2004-2014
Ramathibodi Hospital
1990
Flea and tick specimens (5-10 fleas or ticks) on dogs cats from various sites in Bangkok were tested by polymerase chain reaction DNA sequencing to detect of bacteria Rickettsia (gltA 17 kDa genes), Anaplasmataceae (16S rRNA gene), Bartonella (pap31 its genes). We confirmed that sp. related felis was detected 66 98 (67.4%) flea dogs, whereas 8 henselae 2 clarridgeiae 10 54 (18.5%) cats. Further, this work provides the first evidence Ehrlichia canis (3.3%), 7 Anaplasma platys (2.3%),...
Early diagnosis of leptospirosis is critical for timely treatment and effective disease management. This study evaluated the diagnostic performance a novel electrochemical aptasensor targeting electron transfer flavoprotein subunit beta (EtfB) Leptospira interrogans in clinical samples collected during acute phase leptospirosis. The assay was tested using plasma compared to microscopic agglutination test (MAT), standard reference method. To assess performance, results were against status as...
Background Individuals infected with the 2009 pandemic virus A(H1N1) developed serological response which can be measured by hemagglutination-inhibition (HI) and microneutralization (microNT) assays. Methodology/Principal Findings MicroNT HI assays for specific antibody to were conducted in serum samples collected at end of first epidemic wave from various groups Thai people: laboratory confirmed cases, blood donors health care workers (HCW) Bangkok neighboring province, general population...
A prospective study of childhood encephalitis was performed in Bangkok from 1996 through 1998. The viral agents identifiable 26 (65%) 40 children were dengue virus (8), Japanese (6), herpes simplex (4), human type 6 (3), mumps (2), enterovirus (1), varicella-zoster (VZV) (1) and rabies (1). Various cause encephalitis; the major ones are arboviruses (HSV). Immunization against (JEV), most prevalent arbovirus Asia, has been generally recommended Thailand. This may have reduced relative rate...
The role of human herpesvirus 6 (HHV-6) infection in 227 children born to immunodeficiency virus (HIV)—seropositive mothers was investigated. Of 41 HIV-uninfected infants, 3 (7%) were positive for HHV-6 DNA the first month life, suggesting possible intrauterine infection. cumulative rates at and 12 months age significantly lower HIV-infected (11% 33%, respectively) than uninfected (28% 78%, respectively; P < .001). There an association between high CD4+ cell numbers (>15%) before rate....
There is an urgent need for the development of serodiagnostic approaches with improved sensitivity patients acute leptospirosis. Immunoblots were performed on 188 sera collected from 74 laboratory-confirmed early leptospiral infection to detect immunoglobulin M (IgM) antibodies antigens pooled 10 strains prevalent in Thailand. Sera other febrile diseases served as controls. IgM reactivity seven distinct antigens, apparent molecular masses 14 18, 19 23, 24 30, 32, 35/36, 37, and 41/42 kDa,...
Abstract Leptospirosis is a bacterial zoonotic disease caused by spirochetes in the genus Leptospira . To date, factors determining pathogenicity and virulence of leptospires remain unclear. We performed gel‐based proteomic analysis to evaluate differential leptospiral proteomes pathogenic L. interrogans (serovars Australis, Bratislava, Autumnalis, Icterohaemorrhagiae) non‐pathogenic biflexa (serovar Patoc). Quantitative proteome MS protein identification revealed 42 forms 33 unique proteins...
Influenza vaccination, which has been targeted to the elderly and those at serious risk of complications, is recommended. The purpose this study was determine antibody responses after influenza vaccination among Thai persons living in community. A total 591 subjects consisting 308 vaccinees 283 non-vaccinees were enrolled study. Antibodies H1N1, H3N2, B viruses detected by hemagglutination inhibition (HI) testing. numbers who had protective titers ≥40 geometric mean (GMTs) antibodies against...
Each of the currently available methods for serodiagnosis leptospirosis, including microscopic agglutination test (MAT), has its own drawback(s) when used in clinical practice. A new diagnostic is therefore required an earlier and more accurate diagnosis leptospirosis. We applied immunoproteomics to define potential immunogens from five serovars Leptospira reference strains. leptospiral whole cell lysate each serovar was as antigen react with IgG IgM sera four patients a positive MAT. Sera...
Journal Article A Hospital-Based Study of Acute Viral Infections the Respiratory Tract in Thai Children, with Emphasis on Laboratory Diagnosis Get access Pilaipan Putbavatbana, Putbavatbana From Department Microbiology, Faculty Medicine, Siriraj Hospital, and Pediatrics, Ramathibodi Mahidol University, Bangkok, Thailand Please address requests for reprints to Puthavathana, Bangkok 10700. Thailand. Search other works by this author on: Oxford Academic PubMed Google Scholar Cbantapong Wasi,...
Archival serum samples from elderly individuals with underlying chronic obstructive pulmonary disease (COPD) who were enrolled in a double-blind case-control study of seasonal influenza vaccine efficacy assayed for cross-neutralizing antibody formation to avian A (H5N1) virus. Of 118 samples, 58 collected vaccinees (mean age 68.5 y), and 60 placebo controls 68.4 y) received vitamin B injections. Blood before at 1 mo after vaccination all subjects; addition, longitudinal follow-up period y...
The antibody responses of a reduced-dose intradermal seasonal influenza vaccination have never been studied in COPD patients soon after pandemic. A total 149 (60 y age or older) were randomized to receive trivalent vaccine (Sanofi-Pasteur, France) either 9 µg hemagglutinin (HA) per strain split into 2-site (ID) injections via the Mantoux technique one intramuscular (IM) injection 15 HA strain. geometric mean titers, seroconversion factors, rates and seroprotection for A(H3N2) B administered...
We compared the antibody responses and persistence of reduced-dose, 9 µg hemagglutinin (HA)/strain intradermal (ID) injection via Mantoux technique 15 μg HA/strain intramuscular (IM) repeated annual identical trivalent, inactivated, split-virion vaccine 2011–2012 in chronic obstructive pulmonary disease (COPD) patients. Eighty patients were randomized to ID (n = 41) IM 39) groups. Four weeks post-vaccination, two groups similar; those for influenza A(H1N1)pdm09 A(H3N2)–but not B–met criteria...