A5061121260- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- Hematopoietic Stem Cell Transplantation
- Immunodeficiency and Autoimmune Disorders
- Polyomavirus and related diseases
Allure (United States)
2022
Abstract Purpose: Viral infections are a major cause of morbidity and mortality following allogeneic hematopoietic cell transplantation (allo-HCT). In the absence safe effective antiviral treatments, virus-specific T cells have emerged as promising therapeutic option. Posoleucel is multivirus-specific T-cell therapy for off-the-shelf use against six viral that commonly occur in allo-HCT recipients: adenovirus, BK virus (BKV), cytomegalovirus, Epstein–Barr virus, human herpes virus-6, JC...
Abstract Background Serious viral infections are a leading cause of morbidity and mortality in pediatric recipients allogeneic hematopoietic cell transplant (allo-HCT). Most available antivirals have significant toxicities suboptimal efficacy. Posoleucel (PSL) is an allogeneic, off-the-shelf multi-virus specific T investigational product to prevent or treat 6 (AdV, BKV, CMV, EBV, HHV-6, JCV). In the phase 2 CHARMS trial PSL allo-HCT with intractable infections, 95% patients had clinical...